miR-139-mediated NOTCH1 regulation is crucial for the inhibition of osteosarcoma progression caused by resveratrol

Xiao, Xiangyu; Zhang, Yanqin; Pan, Weinan; Chen, Feng

doi:10.1016/j.lfs.2019.117215

Cited by 25 publications

(10 citation statements)

References 37 publications

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“…These studies highlight the anti‐tumor activity of ATO in different cancers. However, it has been reported that cancer cells can acquire resistance into ATO chemotherapy (Xiao, Zhang, Pan, & Chen, 2020). CT is suggested to be a sensitizer of cancer cells into ATO.…”

Section: Cryptotanshinone In Cancer Therapymentioning

confidence: 99%

Recent advances and future directions in anti‐tumor activity of cryptotanshinone: A mechanistic review

Ashrafizadeh

Zarrabi

Orouei

et al. 2020

Phytotherapy Research

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In respect to the enhanced incidence rate of cancer worldwide, studies have focused on cancer therapy using novel strategies. Chemotherapy is a common strategy in cancer therapy, but its adverse effects and chemoresistance have limited its efficacy. So, attempts have been directed towards minimally invasive cancer therapy using plant derived‐natural compounds. Cryptotanshinone (CT) is a component of salvia miltiorrihiza Bunge, well‐known as Danshen and has a variety of therapeutic and biological activities such as antioxidant, anti‐inflammatory, anti‐diabetic and neuroprotective. Recently, studies have focused on anti‐tumor activity of CT against different cancers. Notably, this herbal compound is efficient in cancer therapy by targeting various molecular signaling pathways. In the present review, we mechanistically describe the anti‐tumor activity of CT with an emphasis on molecular signaling pathways. Then, we evaluate the potential of CT in cancer immunotherapy and enhancing the efficacy of chemotherapy by sensitizing cancer cells into anti‐tumor activity of chemotherapeutic agents, and elevating accumulation of anti‐tumor drugs in cancer cells. Finally, we mention strategies to enhance the anti‐tumor activity of CT, for instance, using nanoparticles to provide targeted drug delivery.

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Section: Cryptotanshinone In Cancer Therapymentioning

confidence: 99%

Recent advances and future directions in anti‐tumor activity of cryptotanshinone: A mechanistic review

Ashrafizadeh

Zarrabi

Orouei

et al. 2020

Phytotherapy Research

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“…notably, recently discovered types of cell death, such as receptor-interacting protein (riP)1-and riP3-dependent necroptosis, as well as ca 2+ /calmodulin-dependent protein kinase type ii a activity-related autophagic degradation, have been considered as efficient anti-osteosarcoma strategies in recent research (46,47). resveratrol, which is structurally similar to oreS, has been shown to induce the apoptosis of osteosarcoma cells via modulating the microRNA139-5p/NOTCH1 signaling pathway (48). additionally, resveratrol can inhibit osteosarcoma MG-63 and MNNG/HOS cell proliferation and tumorigenesis via blocking janus kinase (JAK)2/STAT3 signaling (49).…”

Section: Discussionmentioning

confidence: 99%

Oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the STAT3 signaling pathway in Saos‑2 cells

Jian

et al. 2020

Mol Med Rep

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oxyresveratrol (oreS) is a natural phenolic compound with multiple biological functions including antioxidation, anti-inflammation and neuroprotection; however, the inhibitory effect of oreS on osteosarcoma remains largely unknown. The present study aimed to determine the effects of oreS on osteosarcoma cell Saos-2. cell counting Kit-8 assay was performed to detect Soas-2 cell viability. annexin-FiTc/Pi staining and Jc-1 staining were used to measure cell apoptosis and the change of mitochondrial membrane potential. in addition, western blotting was conducted to determine the expression levels of apoptotic proteins and the phosphorylation of STaT3. it was found that oreS inhibited cell viability and induced apoptosis of osteosarcoma Saos-2 cells in a concentration-dependent manner. in addition, oreS increased the expression levels of apoptotic proteases caspase-9 and caspase-3 and reduced mitochondrial membrane potential. in response to oreS treatment, the expression levels of pro-apoptotic proteins, Bad and Bax, were enhanced, whereas those of anti-apoptotic proteins, Bcl-2 and Bcl-xl, were reduced. in addition, the phosphorylation of STaT3 was attenuated in Saos-2 cells after treatment with oreS. inhibition of cell viability and apoptosis induction by oreS were rescued by enhancement of STaT3 activation upon treatment with il-6. collectively, the present study indicated that oreS induced apoptosis and inhibited cell viability, which may be associated with the inhibition of STAT3 activation; thus, ORES represents a promising agent for treating osteosarcoma.

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“…While miR-139-5p mimics augment the effect of resveratrol, this effect is diminished by miR-139 inhibition. It was shown that miR-139-5p elicits an inhibitory effect on NOTCH1 by directly binding to the 3′ UTR ( Xiao et al, 2020 ).…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy

et al. 2021

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Cancer is a devastating disease and has recently become the leading cause of death in western countries, representing an immense public health burden. When it comes to cancer treatment, chemotherapy is one of the main pillars, especially for advanced stage tumors. Over the years, natural compounds have emerged as one of the most valuable resources for new chemotherapies. It is estimated that more than half of the currently used chemotherapeutic agents are derived from natural compounds. Usually, natural compounds are discovered empirically and an important limitation of introducing new anti-cancer natural products is lack of knowledge with regard to their mechanism of action. Recent data has proven that several natural compounds may function via modulating the expression and function of non-coding RNAs (ncRNAs). NcRNAs are a heterogenous class of RNA molecules which are usually not translated into proteins but have an important role in gene expression regulation and are involved in multiple tumorigenic processes, including response/resistance to pharmacotherapy. In this review, we will discuss how natural compounds function via ncRNAs while summarizing the available data regarding their effects on over 15 types of cancer. Moreover, we will critically analyze the current advances and limitations in understanding the way natural compounds exert these health-promoting effects by acting on ncRNAs. Finally, we will propose several hypotheses that may open new avenues and perspectives regarding the interaction between natural compounds and ncRNAs, which could lead to improved natural compound-based therapeutic strategies in cancer.

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miR-139-mediated NOTCH1 regulation is crucial for the inhibition of osteosarcoma progression caused by resveratrol

Cited by 25 publications

References 37 publications

Recent advances and future directions in anti‐tumor activity of cryptotanshinone: A mechanistic review

Recent advances and future directions in anti‐tumor activity of cryptotanshinone: A mechanistic review

Oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the STAT3 signaling pathway in Saos‑2 cells

Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy

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