MiR-139-5p: promising biomarker for cancer

Zhang, Heda; Jiang, Linhong; Sun, Dawei; Li, Jian; Tang, Jinhai

doi:10.1007/s13277-015-3199-3

Cited by 69 publications

(62 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dysregulated calcium signaling is a classical cancer hallmark and provides chance for cancer diagnosis and therapy [41][42][43]. Calcium signaling pathway is the most significant pathway of DEM in PG compared with adjacent normal brain tissues and miR-139-5p was proved to be associated calcium metabolism by previous studies [38,44,45]. Consistent with our study, several molecular biology and bioinformatics analysis also proved the association between miR-139-5p and GBM [46][47][48].…”

Section: Discussionsupporting

confidence: 89%

Systemic analysis of lncRNA and miRNA expression profiles with associated ceRNA network in glioblastoma

Sun¹,

Liu²,

Song³

et al. 2018

Oncotarget

View full text Add to dashboard Cite

Glioblastoma (GBM) is the most common malignant brain tumor with high morbidity and mortality. Long and small non-coding RNA, i.e. lncRNA and miRNA in this study, play important roles in progression of complex diseases and competes with each other when regulate expression of mRNA. In this study, we conducted systemic analysis of high-throughput gene sequencing and microarray datasets to explore expression regulation patterns in GBM. Differential expression mRNAs, lncRNAs and miRNAs were obtained through comprehensively comparinged their expression profiles between GBM and adjacent non-tumor tissues. As a result, a total of 28 lncRNAs were found to be aberrantly expressed (|log2 (fold change)| > 1, corrected p-value < 0.01) and six out of them were significantly associated with GBM prognosis. The expression changes of the six lncRNAs were further validated through quantative PCR analysis. Finally, lncRNA mediated competition endogenous (ceRNA) network was constructed, which should be helpful for the understanding of lncRNA mediated ceRNA network and identification of prognosis biomarker for GBM.

show abstract

Section: Discussionsupporting

confidence: 89%

Systemic analysis of lncRNA and miRNA expression profiles with associated ceRNA network in glioblastoma

Sun¹,

Liu²,

Song³

et al. 2018

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Interestingly, Lin et al [19] note miR-139-3p up-regulation in CRC with liver metastasis, which may indicate that this miRNA plays a variable role as both oncogene and suppressor in different tumours. Similarly, the frequently studied miR-139-5p also appears to act as oncogene and suppressor gene and regulate multiple processes in various malignancies [44]. Moreover, miR-139-3p is positively correlated with miR-21-3p and miR-885-5p.…”

Section: Discussionmentioning

confidence: 93%

New miRNA expression abnormalities in laryngeal squamous cell carcinoma

Cybula

Wieteska

Józefowicz-Korczyńska

et al. 2016

CBM

View full text Add to dashboard Cite

Abstract. BACKGROUND:Although the development of novel diagnostic and treatment strategies concerning laryngeal cancer is highly intensive, the survival rate remains virtually unchanged. Small non-coding RNAs appear to be very promising biomarkers -and so remain the focus of extensive investigation in laryngeal cancer. OBJECTIVE: We examined the expression of five miRNA and five genes related to cancer whether they could be potential laryngeal cancer biomarkers. METHODS:We performed an analysis in 47 patients diagnosed with laryngeal cancer. The qPCR technique was used to investigate the expression profile. RESULTS: While miR-21-3p and miR-525-5p were found to be significantly up-regulated, miR-139-3p and miR-885-5p expression is lower in laryngeal cancer. Moreover, PIK3R1 and HACE1 were found to be also down-regulated. CONCLUSIONS: The change in miRNA expression is frequent than the expression of other tested genes. The expression of passenger strands such as miR-21-3p and miR-139-3p, which are rarely investigated, is also significantly affected in laryngeal cancer. While PIK3R1, HACE1, miR-139-3p, and miR-885-5p may act as tumor suppressor genes in the studied tumour type, miR-21-3p and miR-525-5p seem to have oncogenic properties. Our findings suggest that miR-885-5p and PIK3R1 are the best indicators for the classification of laryngeal cancer tissue and normal mucosa.

show abstract

“…Dysregulation of miR-139 has been observed in a variety of cancers [8]. Liu et al reported that down-regulation of miR-139 was correlated with poor survival of colon cancer patients [9].…”

Section: Discussionmentioning

confidence: 99%

Identification of a seven-miRNA signature as prognostic biomarker for lung squamous cell carcinoma

Gao

et al. 2016

Oncotarget

View full text Add to dashboard Cite

BackgroundSpecific biomarkers for outcome prediction of lung squamous cell carcinoma (LUSC) are still lacking. This study assessed the prognostic value of differentially expressed miRNAs of LUSC patients.ResultsTwelve of the 133 most significantly altered miRNAs were associated with overall survival (OS) across different clinical subclasses of the Cancer Genome Atlas (TCGA) LUSC cohort. A linear prognostic model of seven miRNAs was developed to divide patients into high- and low-risk groups. Patients assigned to the high-risk group exhibited poor OS compared with patients in the low-risk group, which was further validated in the validation cohort and entire LUSC cohort.MethodsMiRNA expression profiles with clinical information of 447 LUSC patients were obtained from TCGA. Most significantly altered miRNAs were identified between tumor and normal samples. Using survival analysis and supervised principal components method, a seven-miRNA signature for prediction of OS of LUSC patients was established. Survival receiver operating characteristic (ROC) analysis was used to assess the performance of survival prediction. The biological relevance of predicted miRNA targets was also analyzed using bioinformatics method.ConclusionsThe current study suggests that seven-miRNA signature may have clinical implications in the outcome prediction of LUSC.

show abstract

MiR-139-5p: promising biomarker for cancer

Cited by 69 publications

References 99 publications

Systemic analysis of lncRNA and miRNA expression profiles with associated ceRNA network in glioblastoma

Systemic analysis of lncRNA and miRNA expression profiles with associated ceRNA network in glioblastoma

New miRNA expression abnormalities in laryngeal squamous cell carcinoma

Identification of a seven-miRNA signature as prognostic biomarker for lung squamous cell carcinoma

Contact Info

Product

Resources

About