miR‐127‐5p negatively regulates enterovirus 71 replication by directly targeting <scp>SCARB</scp>2

Feng, Cheng; Fu, Yuxuan; Chen, Deyan; Wang, Huanru; Su, Airong; Zhang, Li; Chang, Liang; Zheng, Nan; Wu, Zhiwei

doi:10.1002/2211-5463.12197

Cited by 12 publications

(11 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, Wang et al suggested that circulating miR-876-5p was elevated in response to EV71 infections (Wang et al, 2016). Feng et al reported that miR-127-5p can negatively regulate the replication of enterovirus 71 via targeting SCARB2 (Feng et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Elevated circulating miR-494 in plasma of children with enterovirus 71 induced hand, foot, and mouth disease and its potential diagnostic value

Liu¹,

Lu²,

Wu³

2020

View full text Add to dashboard Cite

hand, foot, and mouth disease (hFMD) is a common pediatric disease, whose outcome depends of the enterovirus genotype infecting the patient. The present study is focused on the potential diagnostic value and the role of circulating microRNA-494 (miR-494) in enterovirus 71-induced more severe form of hFMD. We included 102 children with enterovirus 71 (EV71)-induced hFMD, 42 coxsackievirus A16 (CA16)-induced hFMD and 102 healthy controls. The plasma and serum samples were collected. The expression level of circulating miR-494 was determined by RT-PCR method. Moreover, RoC curve has been drawn to evaluate the sensitivity and specificity of circulating miR-494 for the diagnosis of EV71induced hFMD. Furthermore, the correlation between the circulating miR-494 and the levels of interleukin 6 (iL-6), interleukin 4 (iL-4) and interferon γ (iFN-γ) in the serum of patients were analyzed. Circulating miR-494 was significantly increased in plasma of children with EV71-induced hFMD compared with the healthy children or CA16-induced hFMD, and level of miR-494 in the EV71 severe group was significantly higher than the EV71 mild group. Moreover, results of RoC analysis suggested that miR-494 is a sensitive biomarker to distinguish EV71 patients from healthy controls and CA16 patients. Furthermore, iL-6 and iFN-γ were elevated in serum of patients with EV71-induced hFMD and the level of circulating miR-494 in patients with EV71-induced hFMD was positively correlated with the serum levels of both iL-6 and iFN-γ, respectively. Circulating miR-494 was abnormally up-regulated in plasma of the children with EV71-induced hFMD, and miR-494 may serve as potential biomarker for the diagnosis and treatment of the disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Elevated circulating miR-494 in plasma of children with enterovirus 71 induced hand, foot, and mouth disease and its potential diagnostic value

Liu¹,

Lu²,

Wu³

2020

View full text Add to dashboard Cite

show abstract

“…Directly, miR-127-5p targets the SCARB2 mRNA 3’ untranslated region (UTR) and suppresses expression of SCARB2 in Gaucher fibroblasts ( Siebert et al., 2014 ). Through further experiments, Feng et al confirmed that miR-127-5p expression was upregulated after EV71 infection and that upregulation of miR-127-5p downregulated SCARB2 levels on cell surfaces through specific target binding, which principally affected the susceptibility of uninfected cells to EV71 infection and cell tropism of EV71 ( Feng C. et al., 2017 ). Jin et al found that downregulation of hsa-miR-3605-5p might advance tSCARB2 expression in human embryonic kidney 293T cells infected with coxsackievirus A16 (CVA16), thereby increasing susceptibility to EV71/CVA16 ( Jin et al., 2017 ).…”

Section: Role Of Mirnas In Ev71-induced Cns Infectionmentioning

confidence: 99%

Role of Non-Coding RNA in Neurological Complications Associated With Enterovirus 71

Yang

Zhang

Chen

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Enterovirus 71 (EV71) is the main pathogenic virus that causes hand, foot, and mouth disease (HFMD). Studies have reported that EV71-induced infections including aseptic meningitis, acute flaccid paralysis, and even neurogenic pulmonary edema, can progress to severe neurological complications in infants, young children, and the immunosuppressed population. However, the mechanisms through which EV71 causes neurological diseases have not been fully explored. Non-coding RNAs (ncRNAs), are RNAs that do not code for proteins, play a key role in biological processes and disease development associated with EV71. In this review, we summarized recent advances concerning the impacts of ncRNAs on neurological diseases caused by interaction between EV71 and host, revealing the potential role of ncRNAs in pathogenesis, diagnosis and treatment of EV71-induced neurological complications.

show abstract

“…The overexpression of miRNA-2911 encoded by Honeysuckle reduced EVA71 replication by directly targeting the VP1-coding sequence [ 48 ]. Loss of function of scavenger receptor class B member (SCARB2), a receptor for EVA71 entry, was caused by miR-127-5p, which led to a decrease in viral replication [ 49 ]. Most dysregulated miRNAs during EVA71 infection can interact with host signaling pathways, indirectly affecting virus replication [ 50 , 51 , 52 ].…”

Section: Known Impacts Of Ncrnas On Ev Replicationmentioning

confidence: 99%

Essential Role of Non-Coding RNAs in Enterovirus Infection: From Basic Mechanisms to Clinical Prospects

Zhu

Chen

Zhang

et al. 2021

IJMS

View full text Add to dashboard Cite

Enteroviruses (EVs) are common RNA viruses that can cause various types of human diseases and conditions such as hand, foot, and mouth disease (HFMD), myocarditis, meningitis, sepsis, and respiratory disorders. Although EV infections in most patients are generally mild and self-limiting, a small number of young children can develop serious complications such as encephalitis, acute flaccid paralysis, myocarditis, and cardiorespiratory failure, resulting in fatalities. Established evidence has suggested that certain non-coding RNAs (ncRNAs) such as microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) are involved in the occurrence and progression of many human diseases. Recently, the involvement of ncRNAs in the course of EV infection has been reported. Herein, the authors focus on recent advances in the understanding of ncRNAs in EV infection from basic viral pathogenesis to clinical prospects, providing a reference basis and new ideas for disease prevention and research directions.

show abstract

miR‐127‐5p negatively regulates enterovirus 71 replication by directly targeting SCARB2

Cited by 12 publications

References 49 publications

Elevated circulating miR-494 in plasma of children with enterovirus 71 induced hand, foot, and mouth disease and its potential diagnostic value

Elevated circulating miR-494 in plasma of children with enterovirus 71 induced hand, foot, and mouth disease and its potential diagnostic value

Role of Non-Coding RNA in Neurological Complications Associated With Enterovirus 71

Essential Role of Non-Coding RNAs in Enterovirus Infection: From Basic Mechanisms to Clinical Prospects

Contact Info

Product

Resources

About