MiR‐125b but not miR‐125a is upregulated and exhibits a trend to correlate with enhanced disease severity, inflammation, and increased mortality in sepsis patients

Zhu, Xiaoping

doi:10.1002/jcla.23094

Cited by 16 publications

(6 citation statements)

References 19 publications

(46 reference statements)

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“…Herein, we proposed several possible explanations: (a) Based on our previous finding, higher miR‐125a and miR‐125b expressions correlated with higher inflammation (higher CRP level). CRP levels are considered as an indirect marker for TNF production since production of TNF results in elevated CRP level 14,15 . RA patients with higher CRP levels might benefit more from anti‐TNF treatment than these with lower CRP levels.…”

Section: Discussionmentioning

confidence: 99%

The potential of circulating microRNA‐125a and microRNA‐125b as markers for inflammation and clinical response to infliximab in rheumatoid arthritis patients

Peng

Wang

2020

Clinical Laboratory Analysis

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Objective This study was to investigate the changes in circulating microRNA (miR)‐125a and miR‐125b during infliximab (IFX) treatment, and their value in predicting clinical response to IFX in rheumatoid arthritis (RA) patients. Methods The plasma samples were obtained from 96 active RA patients who underwent 24‐week IFX treatment and from 96 healthy controls to detect miR‐125a and miR‐125b expressions by RT‐qPCR. Clinical response was assessed according to EULAR criteria based on disease activity alleviation at week 4, week 12, and week 24. Results MiR‐125a and miR‐125b expressions were both elevated in RA patients compared with healthy controls, and they could differentiate RA patients from healthy controls by receiver operating characteristic curve analysis. Baseline miR‐125a positively correlated with C‐reactive protein (CRP) level; meanwhile, baseline miR‐125b positively correlated with tender joint count (TJC), swollen joint count (SJC), erythrocyte sedimentation rate (ESR), CRP, and DAS28‐ESR score in RA patients. With the 24‐week IFX treatment, clinical response rate was gradually increased, while miR‐125a and miR‐125b expressions were gradually decreased in RA patients. At week 24, 69 (71.9%) patients responded to IFX treatment, while 27 (28.1%) patients did not respond to IFX treatment. Importantly, baseline miR‐125a and miR‐125b expressions were higher in responders than that in non‐responders, further multivariate logistic regression analysis disclosed that miR‐125b but not miR‐125a could independently predict better clinical response to IFX in RA patients. Conclusion Circulating miR‐125a and miR‐125b displays the potency for guiding personalized treatment strategy and improving clinical outcomes in RA patients.

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Section: Discussionmentioning

confidence: 99%

The potential of circulating microRNA‐125a and microRNA‐125b as markers for inflammation and clinical response to infliximab in rheumatoid arthritis patients

Peng

Wang

2020

Clinical Laboratory Analysis

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“…Four studies [ 21 – 23 , 54 ] were included to analysis the overall diagnostic performance of miR-125a ( S5 Fig ). The summary sensitivity was 0.81 (95%CI, 0.77 to 0.84), and the specificity was 0.67 (95%CI, 0.63 to 0.71).…”

Section: Resultsmentioning

confidence: 99%

Diagnostic significance of microRNAs in sepsis

et al. 2023

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Background Sepsis is a life-threatening condition that induce tens of million death each year, yet early diagnosis remains a formidable challenge. Many studies have focused on the diagnostic accuracy of microRNAs (miRNAs) for sepsis in recent years, particularly miR-155-5p, miR-21, miR-223-3p, miR-146a, and miR-125a. Thus, we conducted this meta-analysis to explore if miRNAs may be used as a biomarker for sepsis detection. Methods We searched PubMed, the Cochrane Central Register of Controlled Trials, EMBASE, and China National Knowledge Infrastructure through May 12, 2022. This meta-analysis was conducted using Meta-disc 1.4 and STATA 15.1 in a fixed/random-effect model. Results The analysis included a total of 50 relevant studies. The overall performance of total miRNAs detection was: pooled sensitivity, 0.76 (95% confidence interval [CI], 0.75 to 0.77); pooled specificity, 0.77 (95%CI, 0.75 to 0.78); and area under the summary receiver operating characteristic curves value (SROC), 0.86. The subgroup analysis suggested that detection in miR-155-5p group had the highest area under the curve (AUC) of SROC among all miRNAs: pooled sensitivity, 0.71 (95%CI, 0.67 to 0.75); pooled specificity, 0.82 (95%CI, 0.76 to 0.86); and SROC, 0.85. MiR-21, miR-223-3p, miR-146a, and miR-125a had SROC values of 0.67, 0.78, 0.69, and 0.74, respectively. The specimen type was found to be a source of heterogeneity in the meta-regression study. The SROC of serum was higher than that of plasma (0.87 and 0.83, respectively). Conclusions Our meta-analysis revealed that miRNAs, specifically miR-155-5p, could be useful biomarkers for detecting sepsis. A clinical serum specimen is also indicated for diagnostic purposes.

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“…Risk of bias is mainly derived from the index test. The conduct or interpretation of the index test introduced high risk in 6 records [ 7 , 8 , 17 , 19 , 23 , 28 ] and unclear risk in 13 articles [ 6 , 14 – 16 , 18 , 20 , 21 , 25 – 27 , 29 – 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Current literature suggested miRNAs played a vital role in the pathophysiology of sepsis and could distinguish the various phases of sepsis [ 6 – 9 , 11 , 14 – 31 ]. Several miRNAs, such as miR-146-a, miR-125b, and miR-223, were positively or negatively associated with sepsis severity [ 22 , 25 , 28 ]. In this present study, the AUC of miRNAs was 0.89 (0.86–0.92), which is higher than that of PCT [0.74 (0.70–0.77)] and CRP [0.77 (0.73–0.81)].…”

Section: Discussionmentioning

confidence: 99%

Accuracy of circulating microRNAs in diagnosis of sepsis: a systematic review and meta-analysis

et al. 2020

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Objectives The aim of this study was to systematically assess the accuracy of circulating microRNAs (miRNAs) as a promising biomarker for sepsis via a meta-analysis. Methods PubMed, Cochrane Library, Embase, Web of Science, Scopus, and Ovid databases were searched up to April 3, 2020. The Quality in Prognostic Studies (QUADAS-2) tool was used to assess methodological quality. The pooled sensitivity (Sen), specificity (Spe), positive or negative likelihood ratios (PLR or NLR), diagnostic odds ratio (DOR), curve, and area under the curve (AUC) were calculated with 95% confidence interval (95% CI). The overall accuracy (OA) of miRNAs, procalcitonin (PCT), and C-reactive protein (CRP) was analyzed by the chi-square test. Results A total of 22 records were eligible for systematic review, including 2210 sepsis, 426 systemic inflammatory response syndrome (SIRS), and 1076 healthy controls (HC). The pooled Sen, Spe, and DOR of miRNAs were 0.80 (95% CI 0.75–0.83), 0.85 (95% CI 0.80–0.89), and 22 (15–32), respectively. The DOR of PCT and CRP were 17 (95% CI 4–68) and 7 (95% CI 1–48), respectively. The OA value of miRNAs (79.02%) and PCT (76.95%) were higher than CRP (61.22%) (P < 0.000). The subgroup analysis indicated that miRNAs in adults, serum type, downregulation of miRNA expression, criteria of Sepsis-3, internal reference of non-U6, and dysregulation expression of miR-223 had superior diagnostic accuracy. In addition, there was no significant publication bias among the included studies. Fagan’s nomogram showed valuable clinical utility. Conclusions Our meta-analysis indicated that the level of circulating miRNAs, particularly the miR-223, could be used as an indicator for sepsis.

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MiR‐125b but not miR‐125a is upregulated and exhibits a trend to correlate with enhanced disease severity, inflammation, and increased mortality in sepsis patients

Cited by 16 publications

References 19 publications

The potential of circulating microRNA‐125a and microRNA‐125b as markers for inflammation and clinical response to infliximab in rheumatoid arthritis patients

The potential of circulating microRNA‐125a and microRNA‐125b as markers for inflammation and clinical response to infliximab in rheumatoid arthritis patients

Diagnostic significance of microRNAs in sepsis

Accuracy of circulating microRNAs in diagnosis of sepsis: a systematic review and meta-analysis

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