MiR-1254 Functions as a Tumor Suppressor in Oral Squamous Cell Carcinoma by Targeting CD36

Chen, Ruixue; Zhang, Yang; Zhang, Xudong

doi:10.1177/1533033819859447

Cited by 21 publications

(20 citation statements)

References 21 publications

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“…22 Chen and colleagues have reported that miR-1254 may restrain the progression of OSCC by downregulating CD36, which may also represent an effective treatment strategy for affected patients. 23 In the present study, we have documented that miR-105 is upregulated in human OSCC tissues and cell lines when compared with non-cancerous tissues and HOK cells, respectively. We have demonstrated that miR-105 expression is closely associated with tumor size as well as clinical and differentiation stages.…”

Section: Discussionsupporting

confidence: 50%

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<p>miR-105 Promotes the Progression and Predicts the Prognosis for Oral Squamous Cell Carcinoma (OSCC)</p>

Hong-yu

2020

CMAR

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Background miRNA-105 has been reported in a vast number of malignancies, including hepatocellular carcinoma and colorectal, esophageal, breast and non-small lung cancers. Still, the biological role of miR-105 remains mostly uncovered in oral squamous cell carcinoma (OSCC). Methods miR-105 expression in OSCC tissues and cell lines was detected by qRT-PCR. Survival analysis was performed using the Kaplan–Meier method, while the prognostic significance of miR-105 was evaluated by Cox regression analysis with a cohort of 90 OSCC patients. The effects of miR-105 on the proliferation of tumor cells were analyzed by CCK-8 assay and crystal violet staining, while cell invasion was assessed by transwell assays. Results Our current work indicates that miR-105 was upregulated in human OSCC tissues and cell lines. Moreover, miR-105 expression was closely associated with tumor size as well as clinical and differentiation stages. Notably, an elevated expression of miR-105 may predict some poor clinical prognosis in OSCC patients. Furthermore, miR-105 overexpression can significantly promote the proliferation and invasion of OSCC cells, whereas downregulation of miR-105 inhibits these cellular events. Conclusion This study demonstrates that miR-105 can promote the proliferation and invasion of OSCC cells. High expression of miR-105 predicts poor prognosis for OSCC and, therefore, it may represent a prognostic biomarker and putative therapeutic target for patients affected by OSCC.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

<p>miR-105 Promotes the Progression and Predicts the Prognosis for Oral Squamous Cell Carcinoma (OSCC)</p>

Hong-yu

2020

CMAR

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“…Previous studies showed that aberrant expression of miRNAs promoted proliferation, migration, invasion and metastasis of HCC cells 30 . It was reported that miR-1254 had anti-tumor activity in oral squamous cell carcinoma by targeting CD36 31 . Another study found that miR-1254 targeted secreted frizzled related protein 1 (SFRP1), a Wnt/β-catenin pathway antagonist, to promote lung cancer cell proliferation 32 .…”

Section: Discussionmentioning

confidence: 99%

Upregulation of miR-1254 promotes Hepatocellular Carcinoma Cell Proliferation, Migration, and Invasion via Inactivation of the Hippo-YAP signaling pathway by decreasing PAX5

Xu¹,

Yang²,

Hu³

et al. 2021

J. Cancer

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“…Targets and functional roles of miRNAs in oral cancer. OSCC (61). Similarly, miR-377 and miR-23a-3p suppressed cell proliferation and promoted apoptosis in OSCC, suggesting that both miR-377 and miR-23a-3p may prove to be of value as therapeutic targets for OSCC in the future (63,64).…”

Section: Mirnas and Oral Cancer Occurrence And Progressionmentioning

confidence: 95%

Diagnostic and therapeutic role of microRNAs in oral cancer (Review)

Wang

et al. 2020

Oncol Rep

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Oral cancer is one of the leading types of cancer and remains the most common cause of cancer-related mortality in Asia. The pathogenesis of oral cancer is complicated and, due to lack of accurate diagnostic methods and efficient treatment strategies, oral cancer is responsible for a large number of deaths. Therefore, there is an urgent need for developing novel diagnostic tools and targeted therapies. MicroRNAs (miRNAs) represent a class of small non-coding RNAs that are key elements and play critical regulatory roles in the pathological processes of various diseases. miRNAs are widely distributed in body fluids and are specifically expressed in different cancers, and they may represent effective biomarkers that may be used for early detection of oral cancer. In addition, miRNAs are involved in oral cancer development, progression and prognosis by targeting a broad range of mRNAs that may be of therapeutic value for oral cancer. The aim of the present review was to summarize the role of miRNAs as new diagnostic tools and potential therapeutic targets in oral cancer, and investigate the underlying molecular mechanisms.

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MiR-1254 Functions as a Tumor Suppressor in Oral Squamous Cell Carcinoma by Targeting CD36

Cited by 21 publications

References 21 publications

<p>miR-105 Promotes the Progression and Predicts the Prognosis for Oral Squamous Cell Carcinoma (OSCC)</p>

<p>miR-105 Promotes the Progression and Predicts the Prognosis for Oral Squamous Cell Carcinoma (OSCC)</p>

Upregulation of miR-1254 promotes Hepatocellular Carcinoma Cell Proliferation, Migration, and Invasion via Inactivation of the Hippo-YAP signaling pathway by decreasing PAX5

Diagnostic and therapeutic role of microRNAs in oral cancer (Review)

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