<p>miR-105 Promotes the Progression and Predicts the Prognosis for Oral Squamous Cell Carcinoma (OSCC)</p>

Abstract

Background miRNA-105 has been reported in a vast number of malignancies, including hepatocellular carcinoma and colorectal, esophageal, breast and non-small lung cancers. Still, the biological role of miR-105 remains mostly uncovered in oral squamous cell carcinoma (OSCC). Methods miR-105 expression in OSCC tissues and cell lines was detected by qRT-PCR. Survival analysis was performed using the Kaplan–Meier method, while the prognostic significance of miR-105 was evaluated by Cox regression analysis with a cohort of 90 OSCC patients. The effects of miR-105 on the proliferation of tumor cells were analyzed by CCK-8 assay and crystal violet staining, while cell invasion was assessed by transwell assays. Results Our current work indicates that miR-105 was upregulated in human OSCC tissues and cell lines. Moreover, miR-105 expression was closely associated with tumor size as well as clinical and differentiation stages. Notably, an elevated expression of miR-105 may predict some poor clinical prognosis in OSCC patients. Furthermore, miR-105 overexpression can significantly promote the proliferation and invasion of OSCC cells, whereas downregulation of miR-105 inhibits these cellular events. Conclusion This study demonstrates that miR-105 can promote the proliferation and invasion of OSCC cells. High expression of miR-105 predicts poor prognosis for OSCC and, therefore, it may represent a prognostic biomarker and putative therapeutic target for patients affected by OSCC.

Integrative analysis of ceRNA network reveals functional lncRNAs associated with independent recurrent prognosis in colon adenocarcinoma

“…These data indicated that PRKAG2-AS1 and SRRM2-AS1 might play roles in the recurrence prognosis of COAD by regulating their corresponding target miRNAs. Except for miR-6514 and miR-3130, accumulating evidence has revealed the functional roles of miR-1275 [ 46 , 47 ] and miR-105 [ 48 , 49 ] in the development of tumorigenesis. The function enrichment analysis identified the PPAR_SIGNALING_PATHWAY and CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION significantly associated with PRKAG2-AS1 and SRRM2-AS1, which might be the recurrence prognosis of COAD.…”

MicroRNAs regulating SOX2 in cancer progression and therapy response

“…MiRNAs are considered as master regulators of molecular pathways in cancers (Refs 44–49). MiRNA dysregulation is an obvious finding in cancer, and these short ncRNAs are reliable biomarkers for cancer detection and prognosis (Refs 50, 51). For instance, in breast cancer patients, miRNA-221 and miRNA-489 demonstrate upregulation and down-regulation in expression, respectively.…”

The Connection between MicroRNAs and Oral Cancer Pathogenesis: Emerging Biomarkers in Oral Cancer Management

“…Altered levels of miRNA expression are highlighted in several neoplastic diseases including cervical [ 18 ], colon [ 19 ], lung [ 20 ], ovarian [ 21 ], and breast cancers [ 22 ]. Recent studies [ 23 , 24 , 25 ] have reported that oral cancers are not an exception to this rule but altered levels of miRNAs can lead to carcinogenesis ( Figure 1 ).…”

“…Altered levels of miRNA expression are highlighted in several neoplastic diseases including cervical [18], colon [19], lung [20], ovarian [21], and breast cancers [22]. Recent studies [23][24][25] have reported that oral cancers are not an exception to this rule but altered levels of miRNAs can lead to carcinogenesis (Figure 1). The purpose of this review is to highlight the essential roles of miRNA dysregulation in oral cancer development and progression, presenting the most relevant transcripts with either tumor suppressor or oncogenic roles.…”