miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7

Abstract

MicroRNAs are highly conserved non-coding RNAs that regulate gene expression at the post-transcriptional level, and play pivotal roles in cancer development and progression. miR-100 has been reported to be significantly downregulated in a variety of cancers, including esophageal cancer. However, the role of miR-100 in human esophageal cancer has not been fully elucidated. We demonstrated that overexpression of miR-100 in esophageal cancer cells markedly inhibited cell proliferation, migration and invasion as well as tumor growth. We subsequently showed that CXCR7 is a direct target gene of miR-100. Our results indicated that miR-100 plays a tumor-suppressor role in esophageal cancer and suggest its potential application for esophageal cancer treatment.

<p>miR-100 Inhibits Cell Growth and Proliferation by Targeting HOXA1 in Nasopharyngeal Carcinoma</p>

“…17,18 Downregulation of miR-100 has been found in esophageal squamous cell carcinoma, non-small cell lung cancer, breast cancer, and so on. [20][21][22] On the other hand, upregulation of miR-100 is observed in small cell lung cancer, renal cell carcinoma, and pancreatic adenocarcinoma, and so on. [23][24][25] It has been also found that miR-100 play vital roles in various biological processes, such as cell proliferation, apoptosis, cell cycle, migration, differentiation, and angiogenesis.…”

MicroRNA-100 suppresses human gastric cancer cell proliferation by targeting CXCR7

“…Collectively, we deducted that miR-100 expression could suppress the cell proliferation in GC. Numerous miR-100 target genes have been identified in previous literatures (17,19,25,29,30). Using the bioinformatical tools, we found the 3'-UTR of CXCR7 has a putative binding site for miR-100 and the luciferase reporter assay confirmed CXCR7 is a direct target of miR-100.…”

“…Growing evidences have found CXCR7 was highly expressed in a variety of human cancers, including GC (22)(23)(24). In particular, CXCR7 functions as a tumor promoter in esophageal squamous cancer and its expression can be regulated by miR-100 (25). However, whether or not miR-100 can regulate the expression of CXCR7 in GC requires more extensive investigations.…”

Non-coding RNAs: new biomarkers and therapeutic targets for esophageal cancer

“…miR-100 was significantly down-regulated in esophageal cancer, and miR-100 overexpression in esophageal cancer cells significantly inhibited cell proliferation, migration and invasion and suppressed tumor growth via targeting CXCR7 [33]. miRNAs can also regulate sphere formation cell proliferation in esophageal cancer.…”

“…miR-100 functions as a tumor suppressor in esophageal cancer, which could be potentially applied in treating esophageal cancer [33]. The miR-124/CDK4 axis was an important mechanism in regulating the radiation sensitivity of human esophageal cancer cells, and targeting CDK4 may improve the clinical efficacy of radiotherapy [48].…”