MIP-Based Impedimetric Sensor for Detecting Dengue Fever Biomarker

Arshad, Rabia; Rhouati, Amina; Hayat, Akhtar; Nawaz, Mian Hasnain; Yameen, Muhammad Arfat; Mujahid, Adnan; Latif, Usman

doi:10.1007/s12010-020-03285-y

Cited by 66 publications

(35 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They showed that the impedimetric measurements had a linear response curve in the concentration range (1‐200 ng/ml) and the electrochemical medical biosensor can specifically detect non‐structural protein 1 as low as 0.3 ng/ml. They also performed experiments in human serum and obtained satisfying recovery values from 95 to 97.14% with less than 5% of standard deviations (Arshad et al, 2020). Dolai and Tabib ‐ Azar reported a paper‐based potentiometric medical biosensor to identify the Zika virus with a minimum sensitivity (0.26 nV/Zika) and a detectable signal (2.4 × 10 7 Zika).…”

Section: Recent Studies Of Medical Biosensorsmentioning

confidence: 97%

Recent advances of medical biosensors for clinical applications

2020

View full text Add to dashboard Cite

The growing requirements for sensing of biomolecules need the development of sensitive, selective, precise, fast and easy-to-use innovative analytical tools for clinical applications Thaler & Luppa, 2019). Quantitative measurements of biomolecules are generally carried out by conventional methods including spectroscopic and chromatographic techniques for extraction, separation and detection Karami et al., 2020;Liu et al., 2019). These conventional techniques are sensitive; however, they require complicated and expensive pieces of equipment and also need expert staff and time to operate them with sample preparation (Eivazzadeh-Keihan et al., 2019;Soler et al., 2020). It is hard to achieve real-time detection of biomolecules by these techniques.New tools with superior sensing capabilities and high spatial localization are urgently needed for especially clinical applications (Rico-Yuste & Carrasco, 2019). The development of biosensors and also powerful, automated and cost-effective diagnostic platforms for the fast and real-time detection of biomolecules have been struggling by researchers Samson et al., 2020;Wang et al., 2020). The scientists from all over the world combine chemistry, biology, physics, electronics, material science, biotechnology and nanotechnology to follow recent developments due to their specific properties of sensing abilities (

show abstract

Section: Recent Studies Of Medical Biosensorsmentioning

confidence: 97%

Recent advances of medical biosensors for clinical applications

2020

View full text Add to dashboard Cite

show abstract

“…In the immune system, antibodies must be specific in recognizing certain antigens. MIP as an alternative to antibodies is often used as an analytical method for diagnostic purposes [ 40 ], such as breast cancer diagnostics [ 41 ], cardiovascular disease [ 42 ], and dengue fever [ 43 ]. Therefore, MIP acts as a biomarker [ 44 ] because it is able to show certain physical characteristics or measurable biologically generated changes in the body associated with certain diseases or health conditions [ 45 ].…”

Section: Mip Applicationmentioning

confidence: 99%

Factors Affecting Preparation of Molecularly Imprinted Polymer and Methods on Finding Template-Monomer Interaction as the Key of Selective Properties of the Materials

et al. 2021

View full text Add to dashboard Cite

Molecular imprinting is a technique for creating artificial recognition sites on polymer matrices that complement the template in terms of size, shape, and spatial arrangement of functional groups. The main advantage of Molecularly Imprinted Polymers (MIP) as the polymer for use with a molecular imprinting technique is that they have high selectivity and affinity for the target molecules used in the molding process. The components of a Molecularly Imprinted Polymer are template, functional monomer, cross-linker, solvent, and initiator. Many things determine the success of a Molecularly Imprinted Polymer, but the Molecularly Imprinted Polymer component and the interaction between template-monomers are the most critical factors. This review will discuss how to find the interaction between template and monomer in Molecularly Imprinted Polymer before polymerization and after polymerization and choose the suitable component for MIP development. Computer simulation, UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Proton-Nuclear Magnetic Resonance (1H-NMR) are generally used to determine the type and strength of intermolecular interaction on pre-polymerization stage. In turn, Suspended State Saturation Transfer Difference High Resolution/Magic Angle Spinning (STD HR/MAS) NMR, Raman Spectroscopy, and Surface-Enhanced Raman Scattering (SERS) and Fluorescence Spectroscopy are used to detect chemical interaction after polymerization. Hydrogen bonding is the type of interaction that is becoming a focus to find on all methods as this interaction strongly contributes to the affinity of molecularly imprinted polymers (MIPs).

show abstract

“…Moreover, EIS offers label free detection of specific antigen-antibody reactions [145]. Till now, different electrochemical based biosensor development approaches have been reported, including carbon nanotube, screen printing, gold nanoparticles, and peptides [148][149][150][151]. EIS technology based on gold nanoparticles (AuNPs) was developed for DENV 1-4 [145].…”

Section: Electrochemical Sensing-based Technologiesmentioning

confidence: 99%

Dengue Detection: Advances in Diagnostic Tools from Conventional Technology to Point of Care

et al. 2021

View full text Add to dashboard Cite

The dengue virus (DENV) is a vector-borne flavivirus that infects around 390 million individuals each year with 2.5 billion being in danger. Having access to testing is paramount in preventing future infections and receiving adequate treatment. Currently, there are numerous conventional methods for DENV testing, such as NS1 based antigen testing, IgM/IgG antibody testing, and Polymerase Chain Reaction (PCR). In addition, novel methods are emerging that can cut both cost and time. Such methods can be effective in rural and low-income areas throughout the world. In this paper, we discuss the structural evolution of the virus followed by a comprehensive review of current dengue detection strategies and methods that are being developed or commercialized. We also discuss the state of art biosensing technologies, evaluated their performance and outline strategies to address challenges posed by the disease. Further, we outline future guidelines for the improved usage of diagnostic tools during recurrence or future outbreaks of DENV.

show abstract

MIP-Based Impedimetric Sensor for Detecting Dengue Fever Biomarker

Cited by 66 publications

References 31 publications

Recent advances of medical biosensors for clinical applications

Recent advances of medical biosensors for clinical applications

Factors Affecting Preparation of Molecularly Imprinted Polymer and Methods on Finding Template-Monomer Interaction as the Key of Selective Properties of the Materials

Dengue Detection: Advances in Diagnostic Tools from Conventional Technology to Point of Care

Contact Info

Product

Resources

About