Miositis osificante circunscrita en un niño de cuatro años

García, D. Cabello; Fernández, Antonio Rodríguez; Rio, Miguel; Moreno, M.; Aguirre, A.C. Rebollo; Castro, Aurelio Martín; Elvira, J.M. Llamas

doi:10.1157/13126193

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…MRI may show prominent lymph nodes, signaling inflammatory response, and may be confused with a metastatic process (50). This hyperinflammatory state is also sensitively appreciated with an intake signal on PET CT and 99mTc diphosphonate bone scintigraphy (12,28). Features in early imaging are not pathognomonic and therefore create confusion.…”

Section: Imagingmentioning

confidence: 99%

Myositis ossificans in the pediatric population: a systematic scoping review

Cherry,

Mutschler,

Samara

et al. 2023

Front. Pediatr.

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IntroductionCircumscribed or pseudomalignant myositis ossificans (MO) is a rare and benign condition characterized by heterotopic bone formation in soft tissues. The clinical presentation of MO, imaging investigations, histological findings, and treatment strategies are unclear, especially in the pediatric population.Materials and methodsA literature search was conducted in PubMed, Scopus, and Google Scholar electronic databases to identify original articles and reviews in English or French of traumatic and non-traumatic MO. Studies were selected by 2 independent reviewers following the PRISMA recommendation and descriptive data were extracted. We harvest in each case the sex, age at diagnosis, location, presence of initial trauma, pre-emptive diagnosis, modalities of imagery used, realized biopsy, treatment performed, and type of follow-up.ResultsSixty pediatric cases of MO were identified between 2002 and 2023. Twenty-three patients (38.3%) were diagnosed with idiopathic/pseudomalignant and 37 patients (61.7%) with circumscribed. The mean age at diagnosis was 9.5 years (range 0.2–17 years), with a male-to-female ratio of 1:1. The initial pre-emptive diagnosis was neoplasia in 13 patients (21.7%). The biopsy was percutaneous in 9 patients (15%) and incisional in 7 patients (11.7%). Histological analysis was achieved in 35 cases (57%). Surgical excision was the first line treatment in 46.7% of patients, and non-surgical in the remaining patients. The follow-up strategy was clinical in 16 patients (26.7%) or based on imaging investigation in 23 patients (38.3%).DiscussionAlthough MO in children is described as a rare pathology, identifying the benignity of the condition is essential to avoid unnecessary invasive treatment and to avoid delaying the treatment of a potentially life-threatening entity. It seems that there is no consensus established concerning the proper imaging for diagnosis. Clinicians should acknowledge that the absence of a triggering trauma tends to direct the investigation and the management toward a surgical attitude. Conservative management is key, however, surgical excision can be proposed on matured lesions on a case-by-case basis. The absence of recurrence is not excluded. Therefore, a close clinical follow-up is suggested for all cases. The true benefit of a radiological is questioned in a question known to be self-resolving.

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Section: Imagingmentioning

confidence: 99%

Myositis ossificans in the pediatric population: a systematic scoping review

Cherry,

Mutschler,

Samara

et al. 2023

Front. Pediatr.

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Myositis ossificans in children: a review

Sferopoulos¹,

Kotakidou²,

Πετρόπουλος

2017

Eur J Orthop Surg Traumatol

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The formation of lamellar bone in the soft tissues, where bone normally does not exist, is called myositis ossificans. However, it would be more accurate to describe as myositis ossificans the involvement of skeletal muscles and as ectopic or heterotopic ossification the involvement of soft tissues in general. The lesion is subdivided in genetic and non-genetic or acquired types. Myositis or fibrodysplasia ossificans progressiva is a debilitating rare genetic disorder. Clinical suspicion of the disease in the newborn on the basis of malformed great toes may lead to early clinical diagnosis, confirmatory diagnostic genetic testing and avoidance of iatrogenic harmful procedures. Acquired lesions involve the neurogenic myositis ossificans and the non-neurogenic disorder. The latter is defined either as circumscribed myositis ossificans that is post-traumatic or as idiopathic/pseudomalignant myositis ossificans that is non-traumatic and may be a form fruste of fibrodysplasia ossificans progressiva. Ossification in fibrodysplasia ossificans progressiva is irreversible, unlike other forms of heterotopic ossification. In this retrospective study, a total of 22 children with myositis ossificans treated in a 20-year period were identified and classified. Two patients were diagnosed with myositis/fibrodysplasia ossificans progressiva, one with neurogenic myositis ossificans, one with idiopathic/pseudomalignant myositis ossificans and 18 patients with circumscribed myositis ossificans. The clinical features, imaging and histological findings as well as treatment modalities and complications of myositis ossificans in our patients are presented and discussed.

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Miositis osificante circunscrita en un niño de cuatro años

Cited by 2 publications

References 17 publications

Myositis ossificans in the pediatric population: a systematic scoping review

Myositis ossificans in the pediatric population: a systematic scoping review

Myositis ossificans in children: a review

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