Minute pancreatic carcinoma with initial symptom of acute pancreatitis

Imamura, Mikio; Asahi, Shuji; Yamauchi, Hidemi; Tadokoro, Keiichi; Suzuki, Hiroyoshi

doi:10.1007/s005340200086

Cited by 12 publications

(6 citation statements)

References 10 publications

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“…The cause of this tumorassociated pancreatitis is not known, but from a number of reports it is obvious that acute pancreatitis in association with a pancreatic neoplasm is not rare and occurs in 5% of pancreatitis patients. [30][31][32][33][34] It is assumed that duct obstruction by the tumor is an initiating factor in this type of pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform

et al. 2005

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Cystic tumors of the pancreas are uncommon but important because of their diverse pathology and biology. Their wide spectrum also includes cystic variants of otherwise solid tumors, such as cystic endocrine tumors, cystic acinar cell carcinomas and ductal adenocarcinomas with cystic changes. In this study, we screened pancreatic ductal adenocarcinomas and their variants for macrocystic changes and determined the nature of the cysts (neoplastic vs non-neoplastic). Of 483 tumors 38 (8%) had cystic features. The largest group consisted of 24 pancreatic ductal adenocarcinomas showing a large-gland pattern with small cysts whose diameter varied between 0.5 and 1.8 cm. The epithelial lining of these cysts was generally positive for CEA (83%) and/or MUC1 (71%) and MUC5AC (74%). p53 was positive in 57% of the cases. The second group of cystic tumors (8/483) showed degenerative cystic cavities with diameters ranging between 1 and 6 cm. This group consisted of poorly differentiated pancreatic ductal adenocarcinomas, undifferentiated carcinomas with or without osteoclast-like giant cells and one adenosquamous carcinoma. In the third group of cystic tumors there were four pancreatic ductal adenocarcinomas containing tumor-related retention cysts. Their epithelial cells were positive for MUC5AC, but negative for CEA, MUC1 and p53. The fourth group consisted of two pancreatic ductal adenocarcinomas showing closely attached pseudocysts caused by tumor-associated pancreatitis. The results indicate that a considerable number of pancreatic ductal adenocarcinomas and their variants display cystic features and must therefore be considered in the differential diagnosis of cystic neoplasms of the pancreas. Moreover, not all of the cystic structures we observed were neoplastic in nature. They may also represent nonneoplastic changes, such as retention cysts and inflammatory pseudocysts.

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Section: Discussionmentioning

confidence: 99%

Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform

et al. 2005

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“…Pancreatitis caused by pancreatic cancer occurs on occasion, with a reported rate of 3% (6). In general, acute pancreatitis is sometimes induced when the pancreatic duct is stenosed due to pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Phase I/II Study: Experience with the Late Onset of Acute Pancreatitis after the Start of Chemotherapy with Gemcitabine Plus nab-Paclitaxel for Metastatic Pancreatic Cancer

Ueno

Nagashima

Ueno³

et al. 2019

Intern. Med.

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Gemcitabine plus nab-paclitaxel is the current standard chemotherapy for patients with metastatic pancreatic cancer. We conducted a phase I/II study in Japan, in which high response rates and manageable toxicity were observed. In this study, two patients were reported as experiencing pancreatitis due to chemotherapy. In general, pancreatitis is sometimes observed when the tumor involves the pancreatic duct, and the onset is observed before the diagnosis or at the initial stage. The onset of pancreatitis in these cases was unique and observed after the start of chemotherapy. Pancreatitis may be induced by the alleviation of stenosis of the pancreatic duct associated with tumor shrinkage.

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“…There are numerous causes of acute pancreatitis (22-44) ( Table 1 ) including alcohol ingestion, biliary tract disease (gallstones/malignancy), surgery/postoperative states (45), trauma (36), metabolic disorders (hypertriglyceridemia, hypercalcemia)(46-49), infections (adenovirus, mumps, ascariasis, mycoplasma) (44, 50), and drugs (the most common include thiazides, sulfa, methyldopa, and procainamide) (51, 52). Malignancies of the pancreas and bile ducts may result in pancreatitis due to obstruction/stenosis of the exocrine pancreatic ducts (53-57). Autodigestion caused by inappropriate intrapancreatic (instead of intestinal) activation of endogenous proteolytic enzymes has been proposed.…”

Section: Discussionmentioning

confidence: 99%

Pancreatitis: A Forensic Perspective

Gill

2016

Academic Forensic Pathology

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Among the numerous etiologies of acute and chronic pancreatitis, several underlying causes (e.g., chronic alcohol abuse, trauma, medical therapy) may result in a death that is reportable to the medical examiner/coroner. As such, forensic pathologists are likely to encounter pancreatitis at autopsy and therefore must be familiar with its etiologies, mechanisms of death, autopsy findings, and medicolegal investigation. This review will focus on the aspects of pancreatitis that may be useful to forensic pathologists in their daily practice. This includes determining if acute or chronic pancreatitis caused or contributed to death as well as determining the etiologically specific proximate cause of death. Current theories of how these various processes result in inflammation of the pancreas are reviewed.

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Minute pancreatic carcinoma with initial symptom of acute pancreatitis

Cited by 12 publications

References 10 publications

Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform

Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform

Phase I/II Study: Experience with the Late Onset of Acute Pancreatitis after the Start of Chemotherapy with Gemcitabine Plus nab-Paclitaxel for Metastatic Pancreatic Cancer

Pancreatitis: A Forensic Perspective

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