Minor gland and whole saliva in postmenopausal women using a low potency oestrogen (oestriol)

Eliasson, Lars; Carlén, Anette; Laine, Merja; Birkhed, Dowen

doi:10.1016/s0003-9969(03)00094-3

Cited by 70 publications

(71 citation statements)

References 33 publications

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“…Previous studies have shown that secretion of proteins and the inorganic components of saliva is hormone-related (Tenovuo et al 1981, Gómez et al 1993, Salvolini et al 1998, Laine & Pienihäkkinen 2000 and HRT appears to increase saliva flow rate, buffer effect and protein content of saliva in menopausal women (Laine & Leimola-Virtanen 1996, Leimola-Virtanen et al 1997, Eliasson et al 2003. In our present study, we identified ER in both mucous and serous acinar and ductal cells in minor salivary glands, and in parotid and submandibular glands.…”

Section: Discussionsupporting

confidence: 68%

“…Similarly, the inorganic and protein composition of saliva changes during the course of pregnancy (Salvolini et al 1998), and in late pregnancy the salivary buffer effect is significantly decreased (Laine & Pienihäkkinen 2000). HRT has been shown to improve the buffering effect of saliva (Laine & Leimola-Virtanen 1996) and, although evidence to the contrary does exist (Streckfus et al 1998, Ghezzi et al 2000, a number of studies (Laine & Leimola-Virtanen 1996, Eliasson et al 2003 have reported an increase in salivary flow rate in association with HRT. Together, these observations suggest that estrogens may play an important role in oral mucosal and salivary gland physiology.…”

Section: Introductionmentioning

confidence: 99%

“…Oral dryness can lead to considerable difficulty in speaking, eating and tasting, and predispose mucosa to wounds, abrasion and infection. A number of studies have shown that hormone replacement therapy (HRT) can relieve this oral discomfort in postmenopausal women, further suggesting a role for female sex hormones in the maintenance of oral tissues (Wardrop et al 1989, Forabosco et al 1992, Leimola-Virtanen et al 1997, Eliasson et al 2003.…”

Section: Introductionmentioning

confidence: 99%

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Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Välimaa

Savolainen

Soukka

et al. 2004

Journal of Endocrinology

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174

149

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Many studies have shown that the oral mucosa and salivary glands are sensitive to estrogen action. However, the expression of estrogen receptors (ERs) within these tissues is an area of controversy. ERs exist as two subtypes (ER and ER ), and we hypothesized that the incongruity between ER expression and estrogen sensitivity may result from differential expression of ER subtypes in oral tissues. To test this hypothesis, we analyzed oral mucosal and salivary gland samples for ER and ER protein expression by immunohistochemistry from a cross-section of patients attending hospital for surgical problems of the head and neck. ER was not detected in oral buccal and gingival epithelium or in salivary glands. In contrast, ER was widely expressed at high levels in all oral tissues studied. Within these tissues, ER was observed primarily in keratinocytes and salivary gland acinar and ductal cells. Our results demonstrating the expression of only the ER subtype within oral tissues may explain the contradictory results from previous studies investigating ER expression in these tissues. Importantly, these results suggest that estrogens may act via ER in oral tissues and explain the effect of hormonal changes on the oral mucosa as well as on saliva secretion and composition.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Välimaa

Savolainen

Soukka

et al. 2004

Journal of Endocrinology

Self Cite

174

149

View full text Add to dashboard Cite

show abstract

“…Due to expression of estrogen receptors within these tissues, decreased estrogen activity not only affects genital organs, but also heart, bone and metabolic functions. Mainly decreased estrogen level in circulating blood affects behaviour and attitude of old age group (Eliasson et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Assessment of periodontal status of postmenopausal women attending dental clinics

SP¹,

Bhat²,

Saloda³

2017

Int J Recent Sci Res

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“…The decrease in estrogen levels during menopause is thought to affect the oral epithelial maturation process, leading to thin and atrophic epithelium [10]. It has been shown that hormone replacement therapy can relieve oral discomfort in menopausal women, further suggesting a role for female sex hormones in the maintenance of oral tissues [11]. Our previous study has also shown that the level of stimulated salivary 17β-estradiol concentration is lower in menopausal women with OD feeling, and there is a negative correlation between OD feeling severity and stimulated whole saliva 17β-estradiol [5].…”

Section: Introductionmentioning

confidence: 99%

Serum 17β-estradiol and oral dryness feeling in menopause

Agha‐Hosseini¹,

Mirzaii‐Dizgah²

2011

Health

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The aim of this study was to compare serum 17β-estradiol of menopausal women with/without Oral Dryness (OD) feeling, and evaluate the relationship between serum 17β-estradiol and severity of OD feeling. A case-control study was carried out on 70 selected menopausal women aged 40 -77 years with or without OD feeling (35 as case, 35 as control) conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia inventory (XI) score was used as an index of OD feeling severity. The serum 17β-estradiol concentration was measured by an enzyme immunoassay kit (ELISA). Statistical analysis of Student's t-test and Spearman correlation coefficient was used. The mean serum concentration of 17β-estradiol was significantly lower in case than control. There was a significant negative correlation between XI score and concentration of 17β-estradiol in menopausal women (r = -0.311, P = 0.004). It seems that there is a negatively slight correlation between OD feeling severity and serum 17β-estradiol in menopausal women.

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Minor gland and whole saliva in postmenopausal women using a low potency oestrogen (oestriol)

Cited by 70 publications

References 33 publications

Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Assessment of periodontal status of postmenopausal women attending dental clinics

Serum 17β-estradiol and oral dryness feeling in menopause

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