Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Välimaa, Hannamari; Savolainen, Saija; Soukka, Tero; Silvoniemi, P.; Mäkelä, Sari; Kujari, Harry; Gustafsson, Jan‐Åke; Laine, Merja

doi:10.1677/joe.0.1800055

Cited by 174 publications

(174 citation statements)

References 40 publications

(53 reference statements)

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“…In addition, MMP-26 can cleave ER-b in vitro and plays an important antitumorigenic role in hormoneregulated malignancies by regulating the amount of ER-b and thus regulating the oestrogen signalling pathway (Savinov et al, 2006). In this study we found, for the first time, that although ER-b, but not ER-a, are expressed in normal oral mucosa (Välimaa et al, 2004) they were both faintly produced in the tongue SCC islands. ER-b is expressed by lymphocytes (Törnwall et al, 1999;Ulziibat et al, 2006), and interestingly we found a weak correlation for the expression of ER-b in inflammatory cells with prolonged survival.…”

Section: Discussionmentioning

confidence: 51%

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

et al. 2008

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Squamous cell carcinoma (SCC) of the tongue is the most common cancer in the oral cavity and has a high mortality rate. A total of 90 mobile tongue SCC samples were analysed for Bryne's malignancy scores, microvascular density, and thickness of the SCC sections. In addition, the staining pattern of cyclooxygenase-2, avb6 integrin, the laminin-5 g2-chain, and matrix metalloproteinases (MMPs) -2, -7, -8, -9, -20, and -28 were analysed. The expression of MMP-8 (collagenase-2) was positively associated with improved survival of the patients and the tendency was particularly prominent in females. No sufficient evidence for a correlation with the clinical outcome was found for any other immunohistological marker. To test the protective role of MMP-8 in tongue carcinogenesis, MMP-8 knockout mice were used. MMP-8 deficient female mice developed tongue SCCs at a significantly higher incidence than wildtype mice exposed to carcinogen 4-Nitroquinoline-N-oxide. Consistently, oestrogen-induced MMP-8 expression in cultured HSC-3 tongue carcinoma cells, and MMP-8 cleaved oestrogen receptor (ER) a and b. According to these data, we propose that, contrary to the role of most proteases produced by human carcinomas, MMP-8 has a protective, probably oestrogen-related role in the growth of mobile tongue SCCs.

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Section: Discussionmentioning

confidence: 51%

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

et al. 2008

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“…Some organs (lung, bladder, intestines) and glands (prostate, pituitary) differ in their expression, with ERβ being greater than ERα [60,[64][65][66]. Notably, within tissues, the distribution of ERα and ERβ can also vary.…”

Section: Erβ-mediated Actions In the Hippocampus For E 2 'S Functionamentioning

confidence: 99%

Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

Walf

Frye

2008

Steroids

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The steroid hormone, estradiol (E 2 ), has numerous targets in the central nervous system, including the hippocampus, which plays a key role in cognition and affective behavior. This review focuses on our evidence from studies in rodents that E 2 has diverse mechanisms in the hippocampus for its functional effects E 2 has rapid, membrane-mediated effects in the hippocampus to enhance cognitive performance. Administration of E 2 to the hippocampus of rats for 10 minutes following training enhances performance in a hippocampus-mediated task. Increased cell firing in the hippocampus occurs within this short time frame. Furthermore, administration of free E 2 or an E 2 conjugate, E 2 :bovine serum albumin (BSA), to the hippocampus produces similar performance-enhancing effects in this task, suggesting that E 2 has membrane actions in the hippocampus for these effects. Further evidence that E 2 has rapid, membrane-mediated effects is that co-administration of E 2 and inhibitors of mitogen activated protein kinase (MAPK), rather than intracellular E 2 receptors (ERs) or protein synthesis, attenuate the enhancing effects of E 2 in this task. Despite these data that demonstrate E 2 can have rapid and/or membrane-mediated effects in the hippocampus, there is clear evidence to suggest that intracellular ERs, particularly the β (rather than α) isoform of ERs, may be important targets for E 2 's functional effects for hippocampal processes. Administration of ligands that are specific for ERβ, but not ERα, have enhancing effects on hippocampal processes similar to that of E 2 (which has similar affinity for ERα and ERβ). These effects are attenuated when ERβ expression is knocked down in transgenic models or with central administration of antisense oligonucleotides. Thus, there may be a convergence of E 2 's actions through rapid, membranemediated effects and intracellular ERs and in the hippocampus for these functional effects.

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“…Hypoestrogenic and hyperglycaemic effects cause the loss of the balance in the body's defence system that induces oxidative stress. In addition, oestrogen supports salivary gland cell maturation and has activating effects on secretion [3]. Diabetes can cause dehydration and inadequate blood glucose control, resulting in the hypofunction of the salivary glands.…”

Section: Discussionmentioning

confidence: 99%

“…Oestrogen receptors are found in the cells of many tissues belonging to the reproductive system organs, brain, kidney, heart, bone, and salivary glands [1][2][3]. These receptors serve as transcription sites for the hormones that function in the area of DNA binding sites.…”

Section: Introductionmentioning

confidence: 99%

Effects of Diabetes on Post-Menopausal Rat Submandibular Glands: A Histopathological and Stereological Examination

et al. 2015

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Objective: The menopause in elderly women is a physiological process where ovarian and uterine cycles end. Diabetes means higher blood glucose level that is a metabolic disease and has an increased incidence. The aim of the study was to examine the single or combined effects of menopause and diabetes that causes pathophysiological processes on submandibular gland on ovariectomy and diabetes induced rat models. Materials and Methods:Sprague Dawley twelve weeks old female (n=24) rats were divided randomly into four groups; Healthy control group (n=6), diabetic group (DM, n=6), ovariectomized group (OVX, n=6), post ovariectomy diabetes induced group (DM+OVX, n=6) individually. Histopathological, histochemical and stereological analyses were done in these groups.Results: Significant neutrophil cell infiltrations and myoepithelial cell proliferations, granular duct and seromucous acini damages and changes in the content of especially seromucous acini secretion in DM and/or OVX groups and distinctive interstitial and striated duct damages in post ovariectomy diabetes induced group were detected. Alterations ingranular ducts hypertrophic and in seromucous acini atrophic were determined in DM and/or OVX groups. Conclusion:The results revealed the pathophysiological processes that lead to morphological and functional alterations on the cellular level in submandibular glands. The molecular mechanisms related with pathogenesis of diabetes and menopause need further investigation.Keywords: Diabetes, gland, menopause, rat, submandibular ÖzetAmaç: İlerleyen yaş ile birlikte, menopoz, kadınlarda gözlenen overial ve menstrual sikluslarda azalma veya bitiş ile karakterize fizyolojik bir süreç ve diyabet ise insidansı artan yüksek kan şekeri seviyesi ile karakterize metabolik hastalıktır. Overektomi ve diyabet indüklenen sıçan modelleri submandibular bezi üzerinde menopozun ve diyabetin tek veya kombine etkilerinin neden olduğu patofizyolojik süreçle-ri incelemek amacı ile çalışma tasarlandı. Gereç ve Yöntem:Sprague Dawley on iki haftalık dişi (n=24) sıçanlar dört gruba randomize bir şekilde rastgele ayrıldı; Sağlıklı Kontrol Grubu (n=6), Diyabetik grup (n=6), Overektomize grup (n=6), Post Overektomize Diyabet İndüklenen Grup (n=6). Sonuçlar histopatolojik, histokimyasal ve stereolojik analizler ile değerlendirildi. Bulgular:Anlamlı nötrofil infiltrasyonları ve myoepitel hücre proliferasyonları, granüler kanal ve seromuköz hücre dejenerasyonları ve özellikle seromuköz asinusların salgısı içeriğindeki değişimler DM ve/veya OVX gruplarında, belirgin intersistiyel ödem ve çizgili kanal dejenerasyonları diyabet indüklenen post overektomize grup submandibular dokularında izlendi. Granular kanallarda hipertrofik değişiklikler, seromuköz asinuslarda atrofik değişiklikler DM ve/veya OVX gruplarında tespit edildi.Sonuç: Diyabet ve overektominin submandibular bezlerinde yol açtığı patofizyolojik süreçlere bağlı hücresel düzeyde morfolojik ve fonksiyonel değişiklikler gösterildi. Diyabet ve menopozun patogenezi ile ilişkili moleküle...

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Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Cited by 174 publications

References 40 publications

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer

Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

Effects of Diabetes on Post-Menopausal Rat Submandibular Glands: A Histopathological and Stereological Examination

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