Minocycline staining of the oral cavity

Berger, R.; Mandel, Edward B.; Hayes, Thomas J.; Grimwood, Ronald R.

doi:10.1016/s0190-9622(89)80309-3

Cited by 49 publications

(29 citation statements)

References 10 publications

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“…55 We were able to find 10 previously published occurrences of alveolar bone pigmentation putatively caused by minocycline.4-5-7-9 17-27-28-55 This is far fewer than would be predicted by the 2% incidence noted by Berger et al 17 It is likely that many of these cases are simply overlooked.…”

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confidence: 69%

Minocycline‐Induced Intraoral Pharmacogenic Pigmentation: Case Reports and Review of the Literature

Westbury¹,

Najera²

1997

Journal of Periodontology

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Minocycline, a semi-synthetic tetracycline antibiotic, is well documented as being associated with pharmacogenic pigmentation of various tissues in humans and other mammals. The most obvious of these are skin pigmentation, but intraorally include "green" roots of erupted teeth, "black" roots of extracted teeth, a dark stain of the crowns of fully developed teeth, and "black" alveolar bone. This article presents five cases of "black" alveolar bone with photographic documentation of its progress. It also reviews the available English language literature on this phenomenon. The incidence of minocycline staining of alveolar bone is probably 2% of that population taking the drug for 2 months or longer. Presently, minocycline is most widely used in the young adult population for the treatment of acne. With the recent interest in minocycline as a palliative treatment for rheumatiod arthritis, an entirely different population could be experiencing this effect. If minocycline use becomes widespread as a treatment for rheumatoid arthritis, it is likely that more practitioners will be asked to diagnose this sometimes striking, though apparently benign, condition. Recognition of this condition will save the practitioner and the patient from unnecessary concern and surgery.

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confidence: 69%

Minocycline‐Induced Intraoral Pharmacogenic Pigmentation: Case Reports and Review of the Literature

Westbury¹,

Najera²

1997

Journal of Periodontology

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“…Previous studies have shown increased prevalence of physiologically increased pigmentation of the fungiform papillae (15,16). Development of pigmentation changes of the tongue have been documented in patients treated with cyclophosphamide and 5-fluorouracil (17)(18).…”

Section: Discussionmentioning

confidence: 98%

Development of Abnormal Pigmentation of the Oral Mucosa Following Adjuvant Radioactive Iodine Treatment

Williams

Hatipoğlu

2016

AACE Clinical Case Reports

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Objective:We report the case of a 52-year-old black woman who developed discoloration of her tongue following radioactive iodine (RAI) ablation. RAI is a common method of treatment for a number of thyroid disorders, including thyroid malignancies and hyperthyroidism. Common side effects of this therapy include hypothyroidism, changes in taste, nausea, and sialadenitis.Methods: This is an Institutional Review Boardapproved single-case chart review with a patient consent.Results: The patient presented with no changes in oral sensation and mild diffuse elongation of the filiform papillae with diffuse, symmetrical, black pigmentation in the distribution of the fungiform papillae 9 days following treatment with RAI. There were no new exposures known to cause a similar reaction, and she had not changed her diet or oral hygiene habits during the development of this symptom.Conclusion: To our knowledge, this is the first documented case of pigmentation change to the tongue following treatment with RAI.

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“…41 Minocycline treatment of severe acne, which is sometimes used for extended periods of treatment, can cause dental and hard palate staining. 3,6 This cosmetic concern should be explained as a rare but potential side effect of treatment. Staining is caused by chelation of iron and the formation of insoluble deposits in skin, hair, and bone.…”

Section: Bone Cartilage and Teethmentioning

confidence: 99%

Antibiotic Precautions in Athletes

Fayock

Voltz²,

Sandella

et al. 2013

Sports Health

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Context:Antibiotics are the mainstay of treatment for bacterial infections in patients of all ages. Athletes who maximally train are at risk for illness and various infections. Routinely used antibiotics have been linked to tendon injuries, cardiac arrhythmias, diarrhea, photosensitivity, cartilage issues, and decreased performance.Evidence Acquisition:Relevant articles published from 1989 to 2012 obtained through searching MEDLINE and OVID. Also, the Food and Drug Administration website was utilized.Study Design:Clinical review.Level of Evidence:Level 3.Results:The team physician should consider alternative medications in place of the “drug of choice” when adverse drug effects are a concern for an athlete’s health or performance. If alternative medications cannot be selected, secondary preventative measures, including sunscreen or probiotics, may be needed.Conclusion:Physicians choose medications based on a variety of factors to help ensure infection resolution while limiting potential side effects. Extra precautions are indicated when treating athletes with certain antibiotics.

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Minocycline staining of the oral cavity

Cited by 49 publications

References 10 publications

Minocycline‐Induced Intraoral Pharmacogenic Pigmentation: Case Reports and Review of the Literature

Minocycline‐Induced Intraoral Pharmacogenic Pigmentation: Case Reports and Review of the Literature

Development of Abnormal Pigmentation of the Oral Mucosa Following Adjuvant Radioactive Iodine Treatment

Antibiotic Precautions in Athletes

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