Development of Abnormal Pigmentation of the Oral Mucosa Following Adjuvant Radioactive Iodine Treatment

Williams, Mia; Hatipoğlu, Betül

doi:10.4158/ep15670.cr

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Most common early side effects of this therapy are nausea, sialadenitis, dry mouth and changes in the taste sensation, salivary gland pain, salivary gland swelling and vomiting (1)(2)(3)(4). Black pigmentation of tongue following RAI therapy is an extremely rare side effect and there are very few cases documented worldwide till now, we found only two reported cases (5,6). Exact etiology of back pigmentation of tongue following RAI therapy is unknown.…”

Section: Introductionmentioning

confidence: 80%

“…This patient presented with black discoloration of the dorsum of the tongue, which is most consistent with post-RAIT. Since the beginning of RAI therapy in 1946, this case indicates one of the rarest side effects following RAI therapy (5). Regarding a mechanism by which RAI could induce pigmentation of the tongue, one study found that the tongue lacks expression of the sodium iodide symporter (6).…”

Section: Discussionmentioning

confidence: 97%

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Black Pigmentation of Tongue Following Radioactive Iodine Therapy: An Interesting & Extremely Rare Case Report

Hossen,

Jahan,

Sharmin

et al. 2024

Bangladesh J. Nuclear Med.

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Radioactive iodine therapy (RAIT) is an effective method of treatment for differentiated thyroid carcinomas after a total or near-total thyroidectomy. Common side effects of this therapy are nausea, sialadenitis, dry mouth, etc. Here we present an extremely rare case of black pigmentation of the tongue in a 28-year-old woman following RAIT after a total thyroidectomy due to papillary thyroid carcinoma (PTC), who presented with black discoloration of the dorsal surface of the tongue following the 3rd day of RAIT. Though the cause of discoloration remains unknown and there was a gradual reduction of dark color, a report should be done about this self-limiting, unusual side effect, which appeared to be apparently non-harmful. Bangladesh J. Nuclear Med. 26(2): 226-228, 2023

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Section: Introductionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 97%

Black Pigmentation of Tongue Following Radioactive Iodine Therapy: An Interesting & Extremely Rare Case Report

Hossen,

Jahan,

Sharmin

et al. 2024

Bangladesh J. Nuclear Med.

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Pigmented Fungiform Papillae (PFP) of the Tongue: A Systematic Review of Current Aetiopathogenesis and Pathophysiology

et al. 2022

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The pigmentation of the fungiform papillae of the tongue is a rare idiopathic condition in which only the fungiform papillae appear hyperpigmented. In the absence of any reviews on the subject, we conducted a systematic review of the aetiopathogenesis and pathophysiology of pigmented fungiform papillae (PFP) of the tongue, including its demographic and histopathological features, trying to outline a possible aetiology. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) was performed using PubMed, Scopus, EMBASE databases and manual searches, for publications between January 1974 and July 2022. Inclusion criteria were case reports defining patients’ characteristics, their general medical and dental conditions, histopathological and/or immunohistochemical findings, all with a final definitive diagnosis of PFP. Overall, 51 studies comprising 69 cases of PFP which included histopathological descriptions were reviewed. Prominent features consisted of hyperpigmentation of melanocytes, melanophages, chromatophores, and a lymphocytic infiltrate in the subepidermal area of the fungiform papillae. On special staining, PFP contained melanin, not iron or hemosiderin. On immunohistochemistry, immune-reactive CD3+ T lymphocytes, S-100 and Sox10, but non-immune-reactive melan-A intraepithelial melanocytes were noted in some studies. The presence of hyperpigmented melanocytes and melanophages, with non-immune-reactive melan-A, suggests that PFP are a benign and physiological form of pigmentation. The inflammatory infiltrates described in some papillary lesions could possibly be due to traumatic events during mastication. Nevertheless, the true reasons for the hyperpigmentation of the fungiform papillae are as of yet elusive, and remain to be determined.

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Development of Abnormal Pigmentation of the Oral Mucosa Following Adjuvant Radioactive Iodine Treatment

Cited by 2 publications

References 14 publications

Black Pigmentation of Tongue Following Radioactive Iodine Therapy: An Interesting & Extremely Rare Case Report

Black Pigmentation of Tongue Following Radioactive Iodine Therapy: An Interesting & Extremely Rare Case Report

Pigmented Fungiform Papillae (PFP) of the Tongue: A Systematic Review of Current Aetiopathogenesis and Pathophysiology

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