Minocycline Ointment as a Local Drug Delivery in the Treatment of Generalized Chronic Periodontitis - A Clinical Study

Abbas, Sara; Mahendra, Jaideep; Ari, Geetha

doi:10.7860/jcdr/2016/19468.7930

Cited by 16 publications

(22 citation statements)

References 33 publications

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“…Minocycline, the representative kind of tetracyclines, is active against important periodontal pathogens such as A. actinomycetemcomitans ; it also has anti-collagenase properties to reduce tissue destruction and bone resorption (Jusko et al., 2016; Olsen et al., 2017; Pokrowiecki et al., 2017). However, the commercial minocycline oniment (Perio ® , 2% dosage of minocycline ointment) inevitable enhanced the adverse effects including the retardation of bone growth, photosensitivity, permanent discoloration of developing teeth, teratogenesis, as well as hepatic and renal toxicity in susceptible individuals (Abbas et al., 2016). Besides, the generation of bacterial resistance is another major challenge that extremely restricts the benefits of minocycline in controlling infections.…”

Section: Discussionmentioning

confidence: 99%

Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation

Mou

Liu

et al. 2019

Drug Delivery

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Periodontal disease is a complex problem which often interrelates with several serious systemic diseases. However, the satisfactory clinical therapy has yet to be achieved. Herein, serum albumin microspheres containing minocycline and zinc oxide nanoparticals (ZnO NPs) were prepared and incorporated in a Carbopol 940 ® hydrogel. Compared with 2% minocycline ointment (Perio ® ), the hydrogel has shown obvious therapy effects and the ability of gingival tissue self-repairing. The serum albumin microspheres containing 0.06% of minocycline and 0.025% of ZnO NPs presented an average size of 139 ± 0.42 nm using electrophoretic light scattering ( n = 3). Photomicrographs obtained by TEM showed homogeneous and spherical-shaped particles. The encapsulation efficiency was 99.99% for minocycline and the slow-release time was more than 72 h with pH-sensitive property. The in vitro skin adhesion experiment showed that the largest bioadhesive force is 0.35 N. Moreover, the hydrogel showed broad-spectrum antimicrobial and effective antibacterial ability when concentration of the ZnO NPs was over 0.2 µg/mL. The cell survival rates were more than 85% below 0.8 mg/L of ZnO NPs, which proved its low toxicity and high security.

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Section: Discussionmentioning

confidence: 99%

Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation

Mou

Liu

et al. 2019

Drug Delivery

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“…The overall results associated with MIN gel revealed no significant advantage over SRD and therefore the authors suggested for further clinical trials for evaluation of its role as an adjuvant medication [ 44 ]. However, another study showed conflicting results (which demonstrated significant reduction in the clinical parameters with improvement in the periodontal status) using the same concentration of drug [ 74 ]. Furthermore, an investigation revealed that periodontal treatment with MIN gel improved the periodontal status and glycemic control with elevation of serum adiponectin in type 2 diabetic patients [ 75 ].…”

Section: General Considerations Of Various Lddsmentioning

confidence: 99%

Professionally Delivered Local Antimicrobials in the Treatment of Patients with Periodontitis—A Narrative Review

et al. 2020

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This review sheds light on the recent published scientific evidence relating to the use of professionally delivered local antimicrobial agents (LA’s). The review also analyses drug delivery systems available to date and provides an update on the latest scientific evidence about the benefits, limitations, and clinical results obtained by use of local drugs in the treatment of periodontal disease. The search strategy revealed randomized controlled trials (RCTs) that compared the efficacy of adjunctive LA’s to mechanical therapy alone. Based on the available evidence gathered from this review, we can infer that the use of local antimicrobial agents in conjunction to scaling and root debridement (SRD) delivers significant benefits in periodontal therapy and it is a useful aid, avoiding many of the side effects that systemic antibiotic therapy may involve. Local drug delivery (LDD) is an efficient and effective means of delivering drugs based on the evidence presented in the review. The authors of this review would suggest the use of local antimicrobials in cases of localized periodontitis or individual areas that do not respond to the usual mechanical therapy alone. This review summarizes the current use of local drug delivery in periodontal management ensuring that the general practitioners are able to choose an appropriate local antimicrobial.

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“…It is one of the most active antibiotics against most of the microorganisms associated with periodontal disease. It has the most marked substantivity and shows greater solubility in lipids [ 11 ]. The minimum inhibitory concentration (MIC) of MH on Enterobacteriaceae, Pseudomonas , Staphylococcus and Candida isolates from periodontal pockets were 16, 128, 8 and 16 μg/mL [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Minocycline Hydrochloride-Loaded In Situ Cubic Liquid Crystal for Intra-Periodontal Pocket Administration

et al. 2018

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In the present study, an injectable in situ liquid crystal formulation was developed for local delivery of minocycline hydrochloride (MH) for chronic periodontitis treatment. The physicochemical properties, phase structures, in vitro drug release and pharmacodynamics of in situ liquid crystals were investigated. The optimal formulation (phytantriol (PT)/propylene glycol (PG)/water, 63/27/10, w/w/w) loaded with 20 mg/g MH was proved to be injectable. The precursor formulation can form a cubic phase gel in excess water in 6.97 ± 0.10 s. The results of in vitro drug release suggested the MH presented a sustained release for 4 days. Liquid crystal precursor formulation significantly reduced gingival index, probing depth and alveolar bone loss compared to the model group (p < 0.01). Besides, the pathological characteristics of model rats were improved. The results suggested that MH-loaded in situ cubic liquid crystal possessed of sustained release ability and periodontal clinical symptoms improvement. The developed in situ cubic liquid crystal may be a potentially carrier in the local delivery of MH for periodontal diseases.

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Minocycline Ointment as a Local Drug Delivery in the Treatment of Generalized Chronic Periodontitis - A Clinical Study

Abstract: The results demonstrate that there was significant reduction in the clinical parameters with improvement in the periodontal status on application of minocycline ointment as an adjunct to periodontal flap surgery in generalized chronic periodontitis.

Cited by 16 publications

References 33 publications

Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation

Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation

Professionally Delivered Local Antimicrobials in the Treatment of Patients with Periodontitis—A Narrative Review

Development and Evaluation of Minocycline Hydrochloride-Loaded In Situ Cubic Liquid Crystal for Intra-Periodontal Pocket Administration

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