Minocycline-Induced Lupus in Adolescents: Clinical Implications for Physical Therapists

Geddes, Rit A

doi:10.2519/jospt.2007.2312

Cited by 11 publications

(5 citation statements)

References 44 publications

(65 reference statements)

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“…In this study, physiotherapists reported serious ADRs, corroborating the interdisciplinary nature of pharmacovigilance activities and their relation to patient safety 31, since these professionals are also able to recognize idiosyncratic events 32,33. Therefore, physiotherapists play an important role in contributing to drug safety analysis and to the prevention, early detection and communication of ADEs 33.…”

Section: Discussionsupporting

confidence: 71%

Effectiveness of pharmacovigilance: multifaceted educational intervention related to the knowledge, skills and attitudes of multidisciplinary hospital staff

Varallo¹,

Planeta²,

Mastroianni³

2017

Clinics

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OBJECTIVES:Most educational interventions in pharmacovigilance are designed to encourage physicians to report adverse drug reactions. However, multidisciplinary teams may play an important role in reporting drug-related problems. This study assessed the impact of a multifaceted educational intervention in pharmacovigilance on the knowledge, skills and attitudes of hospital professionals.METHOD:This prospective, open-label, non-randomized study was performed in a medium-complexity hospital in São Paulo, Brazil. The intervention involved four activities: 1) an interactive lecture, 2) a practical class, 3) a pre-post questionnaire administered to professionals on a multidisciplinary team, and 4) educational material. The intervention’s impact on the professionals’ knowledge and skills was assessed using the World Health Organization’s definitions. The intervention’s effect on the professionals’ attitudes was analysed by the prevalence of adverse drug event reports (adverse drug reactions, medication errors, therapeutic failure and drug quality deviations) and the relevance (seriousness and expectancy) of the events.RESULTS:One hundred seventy-three professionals were enrolled. A 70-fold increase in the number of adverse drug event reports was observed during the 12 months post-intervention. The intervention improved the professionals’ form-completion skills (p<0.0001) and their knowledge of pharmacovigilance (p<0.0001). The intervention also contributed to detecting serious drug-induced events. The nursing staff reported medication errors, and pharmacists and physiotherapists recognized serious adverse drug reactions. Physicians communicated suspicions of therapeutic failure.CONCLUSIONS:A multidisciplinary approach to drug-safety assessments contributes to identifying new, relevant drug-related problems and improving the rate of adverse drug event reporting. This strategy may therefore be applied to improve risk communication in hospitals.

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Section: Discussionsupporting

confidence: 71%

Effectiveness of pharmacovigilance: multifaceted educational intervention related to the knowledge, skills and attitudes of multidisciplinary hospital staff

Varallo¹,

Planeta²,

Mastroianni³

2017

Clinics

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“…Manual analysis of the literature search since 2003 identified 106 publications reporting ADRs observed with tetracyclines, 7–112 including several epidemiological studies. Distributions of those cases according to tetracycline and ADR type are summarized in Table 6.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature

Lebrun‐Vignes

Kreft-Jaïs

Castot

et al. 2012

British Journal of Dermatology

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“…89 In fact, there is no plausible mechanism that explains how minocycline can cause lupus-or any other disease. 90 A more logical explanation may be that certain patients harbor persistent bacterial species that predispose for subclinical lupus.…”

Section: Subclinical Infectionmentioning

confidence: 99%

Immunostimulation in the era of the metagenome

Proal

Albert

Blaney³

et al. 2011

Cell Mol Immunol

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Microbes are increasingly being implicated in autoimmune disease. This calls for a re-evaluation of how these chronic inflammatory illnesses are routinely treated. The standard of care for autoimmune disease remains the use of medications that slow the immune response, while treatments aimed at eradicating microbes seek the exact opposite-stimulation of the innate immune response. Immunostimulation is complicated by a cascade of sequelae, including exacerbated inflammation, which occurs in response to microbial death. Over the past 8 years, we have collaborated with American and international clinical professionals to research a model-based treatment for inflammatory disease. This intervention, designed to stimulate the innate immune response, has required a reevaluation of disease progression and amelioration. Paramount is the inherent conflict between palliation and microbicidal efficacy. Increased microbicidal activity was experienced as immunopathology-a temporary worsening of symptoms. Further studies are needed, but they will require careful planning to manage this immunopathology.

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Minocycline-Induced Lupus in Adolescents: Clinical Implications for Physical Therapists

Cited by 11 publications

References 44 publications

Effectiveness of pharmacovigilance: multifaceted educational intervention related to the knowledge, skills and attitudes of multidisciplinary hospital staff

Effectiveness of pharmacovigilance: multifaceted educational intervention related to the knowledge, skills and attitudes of multidisciplinary hospital staff

Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature

Immunostimulation in the era of the metagenome

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