Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature

Abstract

In the absence of markedly better efficacy against the various indications for tetracyclines, the minocycline benefit/risk ratio was clearly lower than that of doxycycline, and possibly those of lymecycline and metacycline. In light of these findings, minocycline should no longer be considered first-line therapy for inflammatory skin disorders, especially acne.

Tickborne Lymphadenopathy Complicated by Acute Myopericarditis, Spain

“…Although tetracycline-induced cardiac adverse reactions have been described ( 10 ) and the patient reported here had signs of myopericarditis shortly after the initiation of doxycycline, he completed a 4-week treatment without recurrence. Therefore, the clinical picture seems unlikely to be attributable to doxycycline-induced toxicity.…”

DOMINO, doxycycline 40 mg vs. minocycline 100 mg in the treatment of rosacea: a randomized, single-blinded, noninferiority trial, comparing efficacy and safety

“…Serious adverse reactions, including autoimmune disorders and hypersensitivity reactions, such as drug reaction with eosinophilia and systemic symptoms, have been described more often with the use of minocycline than with the other tetracylines . Although the frequency is very low, unlike the other tetracyclines, including doxycycline, minocycline is associated with lupus erythematosus .…”

“…Although the frequency is very low, unlike the other tetracyclines, including doxycycline, minocycline is associated with lupus erythematosus . This risk must be weighed against the benefit of minocycline and, consequently, minocycline must not be considered the first‐line treatment against inflammatory diseases …”

Allergic reaction to the tetracycline component of Ledermix paste: a case report

“…, Lebrun‐Vignes et al . , Travassos et al . ), only one recent letter to the Editor of a dental journal has reported an allergy to Ledermix paste due to demeclocycline, one of the Ledermix paste components that belongs to the tetracycline family (Jetty & Sidebottom ).…”