2000
DOI: 10.1159/000018387
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Minocycline-Induced Lupus

Abstract: Background: Minocycline has increasingly been associated with different adverse auto-immune reactions including drug-induced lupus. Objective: To identify the scope of minocycline-induced lupus and to characterise its typical features. Methods: Comprehensive Medline and Embase search of the English and non-English literature for case reports of minocycline-induced lupus. Results: We included 57 cases of minocycline-induced lupus (mean age ± SD at onset: 21.6 ± 8.6 years, median time of exposure: 19 months, ran… Show more

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Cited by 104 publications
(42 citation statements)
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References 28 publications
(84 reference statements)
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“…For example, minocycline is a potential trigger of drug-induced lupus, and recent studies demonstrate a clear association between increased NFAT1 activity in T cells and systemic lupus erythematosus (55)(56)(57)(58). Paradoxically, in cases of minocyclineinduced lupus, higher doses might prove therapeutic through increased suppression of NFAT1.…”
Section: Discussionmentioning
confidence: 99%
“…For example, minocycline is a potential trigger of drug-induced lupus, and recent studies demonstrate a clear association between increased NFAT1 activity in T cells and systemic lupus erythematosus (55)(56)(57)(58). Paradoxically, in cases of minocyclineinduced lupus, higher doses might prove therapeutic through increased suppression of NFAT1.…”
Section: Discussionmentioning
confidence: 99%
“…Anti-dsDNA antibodies have been observed in patients with TNF-a inhibitor DIL (81) but are rare in procainamide and hydralazine DIL (68). The serologic profile of minocycline DIL is also different from other DIL with the occurrence of positive ANA, anti-dsDNA antibodies, and p-ANCA (82). Complement levels are variably reduced in DIL, and hypocomplementemia is seen more commonly with quinidine and TNF-a inhibitors (67,69).…”
Section: Dil Epidemiology Clinical Presentation and Pathogenesismentioning
confidence: 99%
“…43,48 Because minocycline therapy has the potential for harmful adverse reactions, many authors have confirmed the need for physicians to perform pharmacovigilance, or monitoring of the safety of minocycline drug therapy regimens, to detect serious adverse effects. 4,6,15,16,19,20,25,26,31,34,38,42,[44][45][46]49,50 According to the Guide to Physical Therapist Practice, the initial examination "is a comprehensive screening and specific testing process leading to diagnostic classification, or, as appropriate, to a referral to another practitioner." 2 The inclusion of a comprehensive pharmacovigilance component in the patient examination process augments the ability of the physical therapist to identify when a referral to another practitioner is warranted.…”
Section: Drug-induced Lupusmentioning
confidence: 99%