Minocycline‐Based Europium(III) Chelate Complexes: Synthesis, Luminescent Properties, and Labeling to Streptavidin

Abstract

Dedicated to Professor Jean-Claude Bünzli on the occasion of his 65th birthday Two chelate ligands for europium(III) having minocycline (¼ (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide; 5) as a VIS-light-absorbing group were synthesized as possible VIS-light-excitable stable Eu 3þ complexes for protein labeling. The 9-amino derivative 7 of minocycline was treated with H 6 TTHA (¼ triethylenetetraminehexaacetic acid ¼ 3,6,9,12-tetrakis(carboxymethyl)-3,6,9,12-tetraazatetradecanedioic acid) or (minocycline-TTHA)] (13) was confirmed by UV-absorption semi-quantitative

Design and synthesis of a novel lanthanide fluorescent probe (EuIII-dtpa-(bis)melamine) and application in melamine detection in milk products

“…Nevertheless, due to the π-π* stacking bonding, the melamine is forced to be close to the Eu 3+ ion in Eu III -dtpa-bis(melamine) forming a new coordination bond. As the ligand field around the Eu 3+ ion was changed, the fluorscence intensity of the Eu III -dtpa-bis(melamine) changed obviously [44][45][46][47]. That is, the fluorescence intensity was distinctly enhanced when adding the melamine.…”