Minocyclin-induzierter Lupus erythematodes

Abstract

We report the case of an 18-year-old woman with arthralgia and swelling of distal joints at hands and feet, photosensitive reaction, butterfly rash, fatigue, tachypnea and unspecific cardiac pain three months after beginning a treatment with minocycline for acne. Recurrence of symptoms at a higher intensity occurred within hours of reexposition with minocycline. The antinuclear antibody test was positive. After withdrawal of minocycline, the symptoms improved and minocycline-induced lupus was diagnosed. In the Swissmedic and WHO adverse drug reaction databases 267 other cases of possible minocycline-induced lupus were identified. Typical clinical and laboratory features are arthralgia, arthritis, myalgia, increased transaminases and/or jaundice, unspecific symptoms like fatigue and fever, skin disorders and positive antinuclear antibodies.

Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature

“…Manual analysis of the literature search since 2003 identified 106 publications reporting ADRs observed with tetracyclines, 7–112 including several epidemiological studies. Distributions of those cases according to tetracycline and ADR type are summarized in Table 6.…”