Minireview on Nuclear Spin Polarization in Optically-Pumped Diamond Nitrogen Vacancy Centers

Jeong, Keunhong

doi:10.6564/jkmrs.2016.20.4.114

“…The electron spin polarization can then be transferred to nuclear spins to which the electrons are coupled via the hyperfine interaction, such as 13 C, 14 N or 15 N, either at natural abundance or in an isotopically-enriched sample [242]. This is typically done by matching the external magnetic field to the ground-state level anticrossing (GSLAC) or excited-state level anticrossing (ESLAC) condition during the optical pumping period [243], or by irradiating the diamond with microwaves after optical initialization, which can give efficient transfer at variable magnetic field [242,244]. Recent advances have allowed for the production of suspensions containing 13 C-polarized diamond nanoparticles with polarization levels on the order of 1% [20].…”

Section: Introductionmentioning

confidence: 99%

Synergies between Hyperpolarized NMR and Microfluidics: A Review

Eills

¹

,

Hale

²

,

Utz

³

2022

Progress in Nuclear Magnetic Resonance Spectroscopy

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“…The electron spin polarization can then be transferred to nuclear spins to which the electrons are coupled via the hyperfine interaction, such as 13 C, 14 N or 15 N, either at natural abundance or in an isotopically-enriched sample [242]. This is typically done by matching the external magnetic field to the ground-state level anticrossing (GSLAC) or excited-state level anticrossing (ESLAC) condition during the optical pumping period [243], or by irradiating the diamond with microwaves after optical initialization, which can give efficient transfer at variable magnetic field [242,244]. Recent advances have allowed for the production of suspensions containing 13 C-polarized diamond nanoparticles with polarization levels on the order of 1% [20].…”

Section: Introductionmentioning

confidence: 99%

Synergies between Hyperpolarized NMR and Microfluidics: A Review

Eills¹,

Hale²,

Utz³

2021

Preprint

0

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Hyperpolarized nuclear magnetic resonance and lab-on-a-chip microfluidics are two dynamic, but until recently quite distinct, fields of research. Recent developments in both areas increased their synergistic overlap. By microfluidic integration, many complex experimental steps can be brought together onto a single platform. Microfluidic devices are therefore increasingly finding applications in medical diagnostics, forensic analysis, and biomedical research. In particular, they provide novel and powerful ways to culture cells, cell aggregates, and even functional models of entire organs. Nuclear magnetic resonance is a non-invasive, high-resolution spectroscopic technique which allows real-time process monitoring with chemical specificity. It is ideally suited for observing metabolic and other biological and chemical processes in microfluidic systems. However, its intrinsically low sensitivity has limited its application. Recent advances in nuclear hyperpolarization techniques may change this: under special circumstances, it is possible to enhance NMR signals by up to 5 orders of magnitude, which dramatically extends the utility of NMR in the context of microfluidic systems. At the same time, hyperpolarization requires complex chemical and/or physical manipulations, which in turn may benefit from microfluidic implementation. In fact, many hyperpolarization methodologies rely on processes that are more efficient at the micro-scale, such as molecular diffusion, penetration electromagnetic radiation into the sample, or restricted molecular mobility on a surface. In this review we examine the confluence between the fields of hyperpolarization-enhanced NMR and microfluidics, and assess how these areas of research have mutually benefited one another, and will continue to do so.

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