Synergies between Hyperpolarized NMR and Microfluidics: A Review

Eills, James; Hale, William Gardner; Utz, Marcel

doi:10.1016/j.pnmrs.2021.09.001

“…NV-NMR could overcome these limitations by offering non-invasive measurements of molecular structural information. 105,132,133 Furthermore, NV-NMR could be used to measure parameters such as molecular diffusion, flow rate, pH, or temperature inside the microfluidics, establishing a new analytical platform for Lab-on-a-chip applications.…”

Section: Discussionmentioning

confidence: 99%

Advances in nano- and microscale NMR spectroscopy using diamond quantum sensors

Allert

¹

,

Briegel

²

,

Bucher

³

2022

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“…While mass spectrometry does offer structural information, it destroys the sample and is not generally applicable for every sample and solvent type. NV-NMR could overcome these limitations by offering non-invasive measurements of molecular structural information 105,132,133 . Furthermore, NV-NMR could be used to measure parameters such as molecular diffusion, flow rate, pH, or temperature inside the microfluidics, establishing a new analytical platform for Lab-on-a-chip applications.…”

Section: Discussionmentioning

confidence: 99%

Advances in nano- and microscale NMR spectroscopy using diamond quantum sensors

Allert¹,

Briegel²,

Bucher³

2022

Preprint

0

View full text Add to dashboard Cite

Quantum technologies have seen a rapid developmental surge over the last couple of years. Though often overshadowed by quantum computation, quantum sensors show tremendous potential for widespread applications in chemistry and biology. One system stands out in particular: the nitrogen-vacancy (NV) center in diamond, an atomic-sized sensor allowing the detection of nuclear magnetic resonance (NMR) signals at unprecedented length scales down to a single proton. In this article, we review the fundamentals of NV center-based quantum sensing and its distinct impact on nano- to microscale NMR spectroscopy. Furthermore, we highlight and discuss possible future applications of this novel technology ranging from energy research, material science, or single-cell biology, but also associated challenges of these rapidly developing NMR sensors.

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“…Especially NVdoped nanodiamonds as polarization source for classical NMR demonstrate promising results 137 and have been realized using small form factor setups at room temperature 138 , which could facilitate the practical translation of this technology. Therefore, this method of hyperpolarization could enable easy, low-cost, and efficient hyperpolarization for chemical analytics 132 .…”

Section: Hyperpolarization Using Nv Centersmentioning

confidence: 99%

Advances in nano- and microscale NMR spectroscopy using diamond quantum sensors

Allert

¹

,

Briegel

²

,

Bucher

³

2022

Preprint

2

0

View full text Add to dashboard Cite

Quantum technologies have seen a rapid developmental surge over the last couple of years. Though often overshadowed by quantum computation, quantum sensors show tremendous potential for widespread applications in chemistry and biology. One system stands out in particular: the nitrogen-vacancy (NV) center in diamond, an atomic-sized sensor allowing the detection of nuclear magnetic resonance (NMR) signals at unprecedented length scales down to a single proton. In this article, we review the fundamentals of NV center-based quantum sensing and its distinct impact on nano- to microscale NMR spectroscopy. Furthermore, we highlight and discuss possible future applications of this novel technology ranging from energy research, material science, or single-cell biology, but also associated challenges of these rapidly developing NMR sensors.

show abstract

Synergies between Hyperpolarized NMR and Microfluidics: A Review

Cited by 32 publications

References 259 publications

Advances in nano- and microscale NMR spectroscopy using diamond quantum sensors

Advances in nano- and microscale NMR spectroscopy using diamond quantum sensors

Advances in nano- and microscale NMR spectroscopy using diamond quantum sensors

Advances in nano- and microscale NMR spectroscopy using diamond quantum sensors

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