Minimum infusion rates and recovery times from different durations of continuous infusion of fospropofol, a prodrug of propofol, in rabbits: a comparison with propofol emulsion

Therapeutic Review: Propofol and Fospropofol

“…41 Other studies in rabbits have shown transient tachycardia that may be secondary to a concomitant hypovolemia. 10,14,31 Although not proven, these vascular changes in rabbits may be induced secondary to propofol induced endothelial damage. 42 In vitro studies in rats have shown that propofol induces vasodilation of the aorta.…”

“…In rabbits, higher infusion rates of fospropofol are required to maintain an adequate depth of anesthesia, and rabbits anesthetized with fospropofol had longer recovery times in comparison to those administered propofol. 10 In addition, the use of fospropofol was associated with the anesthetic death of a single rabbit during a prolonged recovery phase. 10 When giving intracoelomically in red-eared sliders, fospropofol was associated with unpredictable quality of anesthesia and prolonged recovery periods, with some turtles requiring resuscitation efforts.…”

“…10 In addition, the use of fospropofol was associated with the anesthetic death of a single rabbit during a prolonged recovery phase. 10 When giving intracoelomically in red-eared sliders, fospropofol was associated with unpredictable quality of anesthesia and prolonged recovery periods, with some turtles requiring resuscitation efforts. 11 Based upon the limited research into this anesthetic agent, its use cannot be recommended for clinical patients at this time.…”

“…28,45 Transient excitatory movements in other species have been reported in blue crabs (Callinectes sapidus) and rabbits (post-fospropofol administration). 10,46 In most situations, propofol is not used solely as an anesthetic agent, but in conjunction with other agents in a balanced anesthetic protocol. Studies in rats and rabbits have shown that administration of an additional sedative, analgesic, and/or dissociative anesthetic will reduce propofol doses required to induce or maintain anesthesia.…”

“…In rabbits administered fospropofol, a transient pruritis, manifested as scratching at the injection site, was noted for 3-5 minutes post injection. 10 Up to 85% of humans administered fospropofol experience tingling, burning, or itching sensations. 9 Respiratory depression, including apnea, is the most common adverse side effect noted after propofol administration.…”