TIVA/TCI in Veterinary Practice

Beths, Thierry

doi:10.1007/978-3-319-47609-4_31

Cited by 3 publications

(4 citation statements)

References 206 publications

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“…Maintenance (Table 3) of anesthesia can be done by administering intravenous anesthetics (total intravenous anesthesia), volatile or mixed (partial intravenous anesthesia). [61,62]. A hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane, and isoflurane can trigger malignant hyperthermia, a pharmacogenetic disorder of skeletal muscle [63].…”

Section: Maintenancementioning

confidence: 99%

Pig Sedation and Anesthesia for Medical Research

Costea,

Ene,

Pavel

2023

Preprint

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Anesthesia ensures the welfare of the animal, enables safe and effective procedures, and allows accurate data collection [1]. In clinical veterinary practice, proper training and expertise in anesthesia administration and monitoring are essential. Pigs are commonly used in medical and scientific research as models for studying various aspects of human health, physiology, and disease due to their physiological and anatomical similarities to humans [2–4]. Pigs are suitable experimental animals for many surgery techniques because they are similar in size to humans and have a short reproductive cycle. This makes them ideal for research concerning organ transplantation, cardiovascular surgery, and other procedures that require a large animal model. Pigs also have a similar anatomy to humans, which makes them a good choice for studying diseases and developing new treatments [5]. Sedation and premedication should be administered at the lowest dose to be effective with predictable results and reduced adverse effects, to ensure the safety of both the animal and the team involved in the procedure, with a fast onset and optimizing the induction and maintenance of anesthesia. The goal of induction is to achieve a safe and effective level of anesthesia that ensures the patient's safety and facilitates the research. Most of the time, inhalation anesthesia with endotracheal intubation is the ideal choice for maintenance., allowing efficient anesthetic management. The difficulties related to the endotracheal intubation of pigs can be overcome by knowing the anatomical peculiarities related to the species and the multiple methods cited in the literature. Effective analgesia tailored to the specific procedure, the pig's condition, and individual responses to medications should complete the maintenance and recovery protocols, reducing perioperative complications.

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Section: Maintenancementioning

confidence: 99%

Pig Sedation and Anesthesia for Medical Research

Costea,

Ene,

Pavel

2023

Preprint

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“…Maintenance (Table 3) of anesthesia can be performed by administering intravenous anesthetics (total intravenous anesthesia-TIVA), volatile/inhaled anesthetics, or mixed (partial intravenous anesthesia-PIVA) [76,77]. A hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane, and isoflurane can trigger malignant hyperthermia, a pharmacogenetic disorder of skeletal muscle [78].…”

Section: Maintenance Of Anesthesiamentioning

confidence: 99%

Pig Sedation and Anesthesia for Medical Research

Costea,

Ene,

Pavel

2023

Animals

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In clinical veterinary practice, proper training and expertise in anesthesia administration and monitoring are essential. Pigs are suitable experimental animals for many surgical techniques because they are similar in size to humans and have a short reproductive cycle. This makes them ideal for research concerning organ transplantation, cardiovascular surgery, and other procedures that require a large animal model. Sedation and premedication should be administered at the lowest dose to be effective with predictable results and reduced adverse effects, to ensure the safety of both the animal and the team involved in the procedure, with a fast onset and optimizing the induction and maintenance of anesthesia. The goal of induction is to achieve a safe and effective level of anesthesia that ensures patient safety and facilitates research. Most of the time, inhalation anesthesia with endotracheal intubation is the ideal choice for maintenance of anesthesia. The difficulties related to endotracheal intubation of pigs can be overcome by knowing the anatomical peculiarities. Effective analgesia tailored to the specific procedure, the pig’s condition, and individual responses to medications should complete the maintenance and recovery protocols, reducing perioperative complications.

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“…General anesthesia can also be maintained using total intravenous anesthesia (TIVA), which is an alternative to inhaled anesthetics [ 14 ]. Because of its pharmacokinetic properties (that allow a rapid onset), ultra-short action, and rapid recovery, propofol has proven to be the most suitable agent for TIVA protocols in dogs, cats, horses, calves and goats [ 14 , 15 ]. Comparatively to inhaled anesthesia, injected anesthesia has a lower cost, and requires minimal equipment for delivery and control [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Because it lacks pain-relieving effects, isoflurane, similar to propofol, should be combined with analgesic drugs for anesthesia during painful procedures; various drugs have been used for this purpose [ 1 , 9 , 10 , 14 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Propofol or Isoflurane Anesthesia Maintenance, Combined with a Fentanyl–Lidocaine–Ketamine Constant-Rate Infusion in Goats Undergoing Abomasotomy

Velázquez-Delgado

Gutiérrez‐Blanco

Torres-Acosta

et al. 2021

Animals

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This study aimed to compare, first, the anesthetic and cardiopulmonary effects of propofol or isoflurane anesthetic maintenance in goats receiving a fentanyl–lidocaine–ketamine infusion undergoing abomasotomy and, secondly, to compare the quality of the recovery from anesthesia. Two groups were used: propofol (TIVA) and isoflurane (PIVA). Goats were premedicated with fentanyl (10 μg/kg intravenously [IV]), lidocaine (2 mg/kg, IV), and ketamine (1.5 mg/kg, IV). Anesthesia was induced with propofol and maintenance consisted of fentanyl (10 μg/kg/h, IV), lidocaine (50 μg/kg/min, IV), and ketamine (50 μg/kg/min, IV) as constant-rate infusions (CRIs), combined with either CRI of propofol at initial dose of 0.3 mg/kg/min, IV (TIVA), or isoflurane with initial end-tidal (FE’Iso) concentration of 1.2% partial intravenous anesthesia (PIVA). The mean effective propofol dose for maintenance was 0.44 ± 0.07 mg/kg/min, while the mean FE’Iso was 0.81 ± 0.2%. Higher systolic arterial pressure (SAP) values were observed in total intravenous anesthesia (TIVA) during some time points. Recovery was smooth in PIVA, while restlessness, vocalizations, and paddling were observed in TIVA. Both protocols produced a satisfactory quality of anesthesia during surgery, with minimal impact on cardiopulmonary function. Nevertheless, recovery after anesthesia in TIVA might be of poor quality.

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TIVA/TCI in Veterinary Practice

Cited by 3 publications

References 206 publications

Pig Sedation and Anesthesia for Medical Research

Pig Sedation and Anesthesia for Medical Research

Pig Sedation and Anesthesia for Medical Research

Comparison of Propofol or Isoflurane Anesthesia Maintenance, Combined with a Fentanyl–Lidocaine–Ketamine Constant-Rate Infusion in Goats Undergoing Abomasotomy

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