Minimizing the risk of macrosomia

Yang, Szu‐Ting; Liu, Chia-Hao; Wang, Peng-Hui

doi:10.1097/jcma.0000000000000901

Cited by 4 publications

(2 citation statements)

References 8 publications

(10 reference statements)

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“…Overweight and obesity during pregnancy are causally associated with fetal overnutrition, leading to increased birth weight and macrosomia [14,15] . Macrosomia may persist throughout childhood and be carried into reproductive age, transmitting obesogenic momentum across generations [16] . Breaking the transgenerational cycle, if confirmed as a causal connection, may be the key to curbing or reversing the inexorable upward obesity trend in both developed and developing countries.…”

Section: Introductionmentioning

confidence: 99%

Macrosomia is associated with overweight in childhood: a follow-back of a cohort established in the early years of the obesity epidemic

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Twum

et al. 2023

Reproductive and Developmental Medicine

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Objective: Interventions currently recommended to control and prevent obesity have not been successful. Recent research has shifted toward the transgenerational cycle of obesity. We assessed the association between fetal macrosomia and early childhood body weight.Methods: We conducted a follow-back study to link birth certificate data to the Third National Health and Nutrition Examination Survey (1988-1994) of 2621 United States-born singletons aged 2-6 years. Birth weight and gestational age data were collected from birth certificates. Fetal macrosomia was defined as ≥90th percentile of gestational age-race-sex-parity specific body weight distribution in 1989 vital statistics.Results: With 12.7% (standard error = 0.85%) of participants born macrosomic, the prevalence of obesity and overweight (BMI percentiles ≥85th in the CDC growth chart) among children was 17.8% (1.17%). When the body weight was measured against age-sex-specific height (BMI percentiles), macrosomia was significantly associated with overweight and obesity (odds ratio [OR] = 1.64, 95% confidence interval = 1.07-2.50) adjusted for family income, maternal age and marital status, race, maternal smoking during pregnancy, and breastfeeding. The association became insignificant after adjusting for postnatal lifestyle and parental body mass index ]. When body weight was measured against age, children who were too heavy for their age were more likely to be born macrosomically ) than their peers with healthy age-specific body weight. Conclusion:Fetal macrosomia was significantly associated with a doubled risk of heavy body weight in children aged 2-6 years.

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Section: Introductionmentioning

confidence: 99%

Macrosomia is associated with overweight in childhood: a follow-back of a cohort established in the early years of the obesity epidemic

Adebile

Orji

Twum

et al. 2023

Reproductive and Developmental Medicine

View full text Add to dashboard Cite

show abstract

“…In recent study, we found that traumatic injury (VD) was a critical precipitating factor associated with the development of POP and repeated traumatic injuries (parity of VDs) or more severe traumatic injuries (macrosomia with four-degree perineal laceration) have further exacerbated the severity and increased the risk of POP. 7,12 Study has shown that absolute risk (AR) of POP surgery was increased by 11.51 per 1000 women by once VD, and further increased by 4.40 for additional VD (twice), 9.07 for three times of VD and 11.43 per 1000 women by ≥4 times of VD, respectively, compared with nulliparous women. 13 Based on the study by Chan et al, 11 all women belonged to multiparty of VDs, further supporting that POP is directly and/or indirectly closely related to the parity of VDs.…”

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confidence: 99%