Minimization of hepatitis B infection by a 25-year universal vaccination program

Ni, Yen‐Hsuan; Chang, Mei–Hwei; Wu, Jia‐Feng; Hsu, Hong–Yuan; Chen, Huey‐Ling; Chen, Ding‐Shinn

doi:10.1016/j.jhep.2012.05.021

Cited by 177 publications

(162 citation statements)

References 35 publications

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“…There had been no increase of HBsAg seropositive rates in cohorts born after the HBV vaccination program was set into place as found in the five consecutive surveys in Taiwan (Fig. 1) (Ni et al 2012). For those who had received vaccinations in infancy, routine booster vaccination may not be required to protect against chronic HBV infection at least before 25 yr of age.…”

Section: Duration Of Protection After Hbv Immunization In Infancymentioning

confidence: 73%

“…We conducted serial seroepidemiologic surveys of HBV markers before and 5, 10, 15, and 20 years after the implementation of the vaccination program in Taipei, Taiwan (Hsu et al 1986;Chen et al 1996;Ni et al 2001Ni et al , 2007Ni et al , 2012. The HBsAg carrier rate decreased steadily from 10% before the vaccination program to 0.6% -0.7% afterward in vaccinated children younger than 20 yr of age.…”

Section: Prevention Of Hbv Infection Hepatitis B and Nephropathymentioning

confidence: 99%

“…1987-1988 1989-1993 1994-1998 1999-2003 2004-2008 Figure 1. Long-term serial seropidemiologic surveys showing no increase of HBsAg-positive rates for at least 20 years in Taiwan (Ni et al 2012). …”

Section: Acknowledgmentsmentioning

confidence: 99%

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Prevention of Hepatitis B

Chang

Chen

2015

Cold Spring Harbor Perspectives in Medicine

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Hepatitis B virus (HBV) causes life-threatening liver disease. It is transmitted through a horizontal route or a mother-to-infant route, and the latter is the major route in endemic areas. Prevention of HBV infection by immunization is the best way to eliminate HBV-related diseases. The HBV vaccine is the first human vaccine using a viral antigen from infected persons, which is safe and effective. Either passive immunization by hepatitis B immunoglobulin (HBIG) or active immunization by HBV vaccine is effective, and a combination of both yields the best efficacy in preventing HBV infection. The impact of universal HBV immunization is huge, with 90%-95% effectiveness in preventing chronic HBV infection. It is the first cancer preventive vaccine with a protective efficacy against hepatocellular carcinoma (HCC) of 70%. Nevertheless, further effort is still needed to avoid vaccine failure and to increase the global coverage rate.

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Section: Duration Of Protection After Hbv Immunization In Infancymentioning

confidence: 73%

Section: Prevention Of Hbv Infection Hepatitis B and Nephropathymentioning

confidence: 99%

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Prevention of Hepatitis B

Chang

Chen

2015

Cold Spring Harbor Perspectives in Medicine

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“…Before the launch of the universal childhood HBV vaccination policy in 1984, the prevalence rate of HBV infection in Taiwan was 15% to 20% [3]. Studies spanning a 23-year post-vaccination period showed a significant decrease in chronic hepatitis B (CHB) infections (hepatitis B surface antigen [HbsAg] seropositive for ≥6 months) with HBsAg seropositivity reducing from ~14.3% up to ~0.9% [4][5][6]. Further, mortality due to fulminant hepatic failure and HCC also dramatically decreased following implementation of the vaccination program [7].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B and C in Taiwanese patients with Schizophrenia: A Nationwide, Population-based study on prevalence, and healthcare utilization

Wang

Tang²,

Tsai

et al. 2017

J Psychol Psychiatry

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Introduction: Hepatic viral infections (hepatitis B virus (HBV) and hepatitis C virus (HCV)) are endemic in Taiwan, and can progress to liver cirrhosis and hepatocellular carcinoma. Schizophrenia patients present substantial undiagnosed and untreated comorbidities compared with the general population. Hence, the prevalence of comorbid HBV/HCV infections in, and healthcare utilization by patients with schizophrenia should be determined.

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“…8 Currently, hepatitis B vaccination is regarded as the most economical and effective method for the prevention and control of hepatitis B infection. [9][10][11][12] The universal infantile hepatitis B vaccination program began in China in the year 1992. After more than 10 y of mass hepatitis B vaccination, a great success in the prevention and control of HBV infection had been achieved.…”

Section: Introductionmentioning

confidence: 99%

The response of hepatitis B vaccination on seronegative adults with different vaccination schedules

Yao

Chen

et al. 2015

Human Vaccines & Immunotherapeutics

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y These authors equally contributed to this work. Keywords: Hepatitis B vaccine, immunization, adults, ChinaThe purpose of this study was to compare the response of hepatitis B vaccination with different vaccination schedules among seronegative adults, and to provide suitable vaccination schedules for floating and fixed population. The study included adults aged 20 to 39 y without prior history of vaccination with hepatitis B vaccine. The serum samples were collected and tested for hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc) levels. Out of all, 686 adults who were negative for anti-HBs, anti-HBc and HBsAg were vaccinated with 10 ug hepatitis B vaccine at 0, 1 and 3, 6 or 12 month schedules, and their antibody titers were monitored. The rates of completion of the vaccination in floating and fixed population were 90.4% and 94.1% respectively (p D 0.061). The anti-HBs positive rates in adults vaccinated at 0, 1 and 3 ,6 or12 month were 83.9%, 88.2% and 94.2% respectively (P D 0.0003). The corresponding geometric mean titers (GMTs) were 61.19 (95%CI:47.10-81.23) mIU/mL, 214.04(95%CI:157.14-291.61) mIU/mL and 345.78(95%CI:251.25-475.77) mIU/mL, respectively ( P < 0.0001). Vaccination of hepatitis B with both 0-1-6 and 0-1-12 month schedules in adults result in better level of immune responses. Also, a longer vaccination schedule (0-1-12 month) may be more suitable for floating population and 0-1-6 month schedule is recommended for the fixed population.

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Minimization of hepatitis B infection by a 25-year universal vaccination program

Cited by 177 publications

References 35 publications

Prevention of Hepatitis B

Prevention of Hepatitis B

Hepatitis B and C in Taiwanese patients with Schizophrenia: A Nationwide, Population-based study on prevalence, and healthcare utilization

The response of hepatitis B vaccination on seronegative adults with different vaccination schedules

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