“…Antifungal prophylaxis introduced in HCT patients and in patients with acute leukemias in 2014-2015, slowed down the increase in incidence of fungal infections from 2016 onwards, although it did not stop it. Looking into possible activities, other options to improve the outcome of IFD might be: wider use of invasive diagnostics, treatment with reference antifungals according to recommendations [9,17], use of minimally-invasive surgery in diagnostics and treatment [32,33], or successful prophylaxis and treatment of viral infections preceding development of IFD [4,34,35]. New diagnostic methods and antifungals may appear.…”