High risk of invasive fungal disease in children undergoing hematopoietic cell transplantation or complex anticancer therapy: the adverse role of post-transplant CMV replication

Abstract

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Etiologic Structure of Fungi Isolated in Children with Oncohematological Diseases in Removed Central Venous Catheters and Assessment of the Role of Fungal Pathogens in the Development of Catheter-Associated Infections of Bloodstream

“…Данный вид оказания медицинской помощи широко используется в отделениях реанимации и интенсивной терапии (ОРИТ), а также в стационарах гематологического и онкологического профиля [10][11][12]. Группой особого риска развития гематогенных инвазивных микозов являются лица с иммуносупрессивным статусом на фоне основной патологии (онкогематологические заболевания, врожденные и приобретенные иммунодефицитные состояния), реципиенты трансплантатов органов и тканей [13][14][15]. В свою очередь, риск развития инфекций кровотока тесно связан с видом применяемых катетеров (имплантируемых, туннельных, нетуннельных и т.…”

Invasive fungal disease presenting as septic shock in immunocompromised pediatric and adult patients: summary of reported cases

“…No major differences in etiology between children and adults have been reported [3][4][5][6], although in one study the incidence of IFD after allo-HCT was significantly higher in children than in adults [6]. Regardless of age, patients in the following groups are considered high-risk for IFD: acute myeloblastic leukemia (AML); recurrent acute leukemia; allogeneic hematopoietic stem cell transplantation; and high risk acute lymphoblastic Tomasz Styczyński et al, IFD as septic shock leukemia (ALL) [4,5,[7][8][9]. Coexisting cytomegalovirus replication increases the risk of fungal complications [9].…”

“…Regardless of age, patients in the following groups are considered high-risk for IFD: acute myeloblastic leukemia (AML); recurrent acute leukemia; allogeneic hematopoietic stem cell transplantation; and high risk acute lymphoblastic Tomasz Styczyński et al, IFD as septic shock leukemia (ALL) [4,5,[7][8][9]. Coexisting cytomegalovirus replication increases the risk of fungal complications [9].…”

Revolution in management of CMV infection after hematopoietic cell transplantation

“…Cytomegalovirus (CMV) infection is a major complication after allogeneic hematopoietic cell transplantation (allo-HCT), and a serious trigger for other sequelae [1][2][3]. The introduction of letermovir into the prophylaxis of CMV infection has led to a large reduction of the CMV reactivation rate in seropositive adult patients after allo-HCT [4][5].…”