“…Malapposition and noncircularity might lead to leaflet malcoaptation, resulting in regurgitation and early degeneration of the device. The overall experience of VIR is mostly limited to isolated clinical case reports, small series and animal studies [10,14,[22][23][24] . Descoutures et al [10] reported preliminary multicenter results of 17 cases, and that VIR may provide short-term clinical and hemodynamic improvement.…”