Minimally-invasive methods for examining biological changes in response to chronic stress: A scoping review

Salomon, Rebecca E.; Tan, Kelly R.; Vaughan, Ashley; Adynski, Harry; Muscatell, Keely A.

doi:10.1016/j.ijnurstu.2019.103419

Cited by 5 publications

(7 citation statements)

References 176 publications

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“…Blood and urine also contain these biomarkers, but saliva, which can be collected easily and noninvasively, is more useful in a work setting [ 18 ]. The choice of these biomarkers to examine physiological responses to work-related stress and fatigue depends on the type of stress investigated, with the hypothalamic–pituitary–adrenal axis and immune function being considered relevant for chronic conditions [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cortisol, a glucocorticoid hormone secreted by the adrenal cortex, is regulated by negative feedback from the hypothalamus and pituitary gland [ 19 , 20 , 21 ]. Previous studies have suggested associations between salivary cortisol and fatigue among community-dwelling adults [ 20 ], depression [ 21 , 22 , 23 ], anxiety [ 24 ], and chronic fatigue syndrome [ 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…Given the association between work-related stress and chronic fatigue, previous findings are useful in exploring associations between salivary biomarkers and chronic fatigue in nurses. However, salivary biomarker levels can easily change due to factors such as sampling time, lifestyle, and psychological conditions [ 17 , 19 ]. Therefore, to investigate the association between salivary biomarkers and nurses’ fatigue, a study that measures salivary biomarkers over a period is warranted [ 33 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

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Salivary Biomarker Profiles and Chronic Fatigue among Nurses Working Rotation Shifts: An Exploratory Pilot Study

et al. 2022

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Although nurses’ fatigue affects their well-being and patient safety, no effective objective measurements exist. We explored the profiles of salivary biomarkers associated with nurses’ chronic fatigue across several shifts. This longitudinal study involved 45 shiftwork nurses and collected their saliva samples before two night and two day shifts for a month. Chronic fatigue was measured using the Cumulative Fatigue Symptom Index before the first night shift. Biomarker profiles were analyzed using hierarchical cluster analysis, and chronic fatigue levels were compared between the profiles. Cortisol profiles were classified into high- and low-level groups across two day shifts; the low-level group presented significantly higher irritability and unwillingness to work. Secretory immunoglobulin A (s-IgA) profiles across the four shifts were classified into high- and low-level groups; the high-level group had significantly higher depressive feelings, decreased vitality, irritability, and unwillingness to work. Cortisol (two day shifts) and s-IgA (four shifts) profiles were combined, and (i) cortisol low-level and s-IgA high-level and (ii) cortisol high-level and s-IgA low-level groups were identified. The former group had significantly higher chronic fatigue sign and irritability than the latter group. The profiles of salivary cortisol and s-IgA across several shifts were associated with nurses’ chronic fatigue.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Salivary Biomarker Profiles and Chronic Fatigue among Nurses Working Rotation Shifts: An Exploratory Pilot Study

et al. 2022

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“…(13,43) A introdução desse tipo de método para a avaliação e o manejo da dor pode contribuir para a prática clínica, em especial da equipe de enfermagem. (48,49) O desenvolvimento e estabelecimento de técnicas e dispositivos consistentes e viáveis para a análise beira leito é necessário, bem como o desenvolvimento de protocolos para padronizar a avaliação das diferentes moléculas salivares que apresentam oscilação ao longo do dia e em resposta a diferentes situações.…”

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Biomarcadores salivares na avaliação da dor: revisão integrativa

Rocha¹,

Freitas²,

Silva³

et al. 2022

Acta Paulista De Enfermagem

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Conflitos de interesse: nada a declarar. ResumoObjetivo: Identificar os principais biomarcadores salivares descritos, assim como as técnicas empregadas para coleta das amostras de saliva, em estudos relacionados à avaliação da dor em pacientes submetidos a procedimentos dolorosos ou portadores de patologias dolorosas.Métodos: Revisão integrativa da literatura, realizada pelas buscas bibliográficas nas bases Biblioteca Virtual em Saúde (BVS), MEDLINE/PubMed, CINAHL e EMBASE, com recorte temporal de 2009 a 2019 e período de coleta de dados entre outubro e novembro de 2019. Foram utilizados Descritores em Saúde (DeCs)e Medical SubjectHeadings (MeSH), para responder à pergunta norteadora: Quais são e como são utilizados os biomarcadores salivares na avaliação da dor? Foi realizada uma análise descritiva dos artigos, sendo os dados extraídos e registrados em uma planilha desenvolvida para o presente estudo.Resultados: Das 126 publicações identificadas, 22 artigos foram incluídos para a análise. Constatou-se que os artigos são, majoritariamente, desenvolvidos com adultos durante realização de procedimentos dolorosos ou portadores de patologias dolorosa. Os principais biomarcadores salivares avaliados foram a alfa-amilase e o cortisol, e as principais técnicas para coleta de saliva foram o Salivette ® e a coleta passiva.Conclusão: Os estudos indicam que a mensuração objetiva da dor é um desafio. Os principais biomarcadores salivares descritos são o cortisol e a alfa-amilase, sendo o Salivette ® a principal técnica utilizada para coleta das amostras de saliva. A dosagem das moléculas salivares é incipiente e empregada de forma complementar na avaliação da dor em pacientes de diferentes faixas estárias, submetidos à procedimentos dolorosos ou portadores patologias dolorosas.

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“…Despite its growing importance, the respective research base on work stress, immune function, and inflammatory processes specifically for care professionals is limited and inconsistent [25][26][27]. Previous investigations into work-related influences on nursing professionals' immune system predominantly surveyed the role of shift work [28,29], overall professional stress [30,31], and mediating experiences of job satisfaction [32].…”

Section: Introductionmentioning

confidence: 99%

Psychosocial working conditions and chronic low-grade inflammation in geriatric care professionals: A cross-sectional study

et al. 2022

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Background Chronic low-grade inflammation has been suggested as a key factor in the association between stress exposure and long-term health. Care work is recognized as a profession with a high degree of job stress and health risks. However, for care professionals, the study base on inflammatory activity due to adverse working conditions is limited. Objective The aim of this study was to explore associations between self-reported psychosocial working conditions and care professionals’ biomarkers of systemic low-grade inflammation. Methods N = 140 geriatric care professionals (79.3% females, mean age = 44.1 years) of six care facilities were enrolled in a cross-sectional study consisting of standardized medical examinations and employee surveys. Standardized questionnaires were used for evaluation of psychosocial work characteristics (work overload, job autonomy, social support) based on Karasek’s job strain model. Blood samples were drawn for two biomarkers of inflammatory activity: C-reactive protein (CRP) and leukocyte count. Analyses comprised uni- and multivariate logistic and linear regression analyses. Results We determined a proportion of 5.4% of care professionals with increased low-grade inflammation. We further observed a relationship between job autonomy and CRP, such that reports of high job autonomy were associated with increased levels of CRP (adjusted OR = 4.10, 95% CI [1.10, 15.26], p = .035), which was robust in additional analyses on further potential confounders. No significant associations with participants’ leukocyte numbers were found. Conclusions This exploratory study contributes to the research base on links between workplace stress and ensuing illness in care professionals. Our findings may help to identify risk and protective factors of the work environment for chronic low-grade inflammation. The results require further scrutiny, and future prospective studies on associations of psychosocial working conditions, low-grade inflammation and long-term health outcomes in care professionals are needed.

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Minimally-invasive methods for examining biological changes in response to chronic stress: A scoping review

Cited by 5 publications

References 176 publications

Salivary Biomarker Profiles and Chronic Fatigue among Nurses Working Rotation Shifts: An Exploratory Pilot Study

Salivary Biomarker Profiles and Chronic Fatigue among Nurses Working Rotation Shifts: An Exploratory Pilot Study

Biomarcadores salivares na avaliação da dor: revisão integrativa

Psychosocial working conditions and chronic low-grade inflammation in geriatric care professionals: A cross-sectional study

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