Minimally and Non-invasive Approaches to Rejection Identification in Vascularized Composite Allotransplantation

Stead, Thor S.; Brydges, Hilliard T.; Laspro, Matteo; Onuh, Ogechukwu C.; Chaya, Bachar F.; Rabbani, Piul S.; Lu, Catherine P.; Ceradini, Daniel J.; Gelb, Bruce E.; Rodriguez, Eduardo D.

doi:10.1016/j.trre.2023.100790

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…These modalities require further validation but show promise to detect early rejection, which may be of particular benefit during the reduction of immunosuppression ( 27 ). An alternative budding strategy is the measurement of serum biomarkers, such as matrix metalloproteinase-3 or donor-derived microparticles, which have been shown to rise with rejection in preliminary studies among VCA recipients ( 28 ). However, the determination of accurate biomarkers has been challenging in this population due to the small number of VCA patients.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Post-transplant lymphoproliferative disorder as a serious complication of vascularized composite allotransplantation

Zaccardelli,

Lucas,

LaCasce

et al. 2024

Front. Transplant.

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Vascularized composite allotransplantation (VCA) is an emerging field in transplant surgery. Despite overall positive outcomes, VCA confers risk for multiple complications related to the procedure and subsequent immunosuppression. Post-transplant lymphoproliferative disorder (PTLD) is a heterogeneous group of lymphoproliferative disorders occurring after solid organ and hematopoietic stem cell transplant. A patient with PTLD after bilateral upper extremity transplantation is presented as well as a review of all known cases of PTLD after VCA, with a focus on the unique epidemiology, presentation, and treatment in this population.

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Section: Discussionmentioning

confidence: 99%

Case Report: Post-transplant lymphoproliferative disorder as a serious complication of vascularized composite allotransplantation

Zaccardelli,

Lucas,

LaCasce

et al. 2024

Front. Transplant.

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“…Upon visual examination, acute rejection is characterized by redness, maculopapular rash, edema, induration, lesion, and/or oral ulceration ( 12 , 25 ). Since the clinical appearance of early rejection is not entirely specific and highly subjective, a skin biopsy is obtained and evaluated histologically using the Banff classification of skin rejection established in 2007 ( 26 ). The Banff classification characterizes the degree of rejection in terms of localization and intensity of the inflammatory infiltrate and presence of target cell injury ( 25 ).…”

Section: Vca Rejectionmentioning

confidence: 99%

Immunogenicity and tolerance induction in vascularized composite allotransplantation

Sun,

Adil,

Biniazan

et al. 2024

Front. Transplant.

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Vascularized composite allotransplantation (VCA) is the transplantation of multiple tissues such as skin, muscle, bone, nerve, and vessels, as a functional unit (i.e., hand or face) to patients suffering from major tissue trauma and functional deficits. Though the surgical feasibility has been optimized, issues regarding graft rejection remains. VCA rejection involves a diverse population of cells but is primarily driven by both donor and recipient lymphocytes, antigen-presenting cells, macrophages, and other immune as well as donor-derived cells. In addition, it is commonly understood that different tissues within VCA, such as the skin, elicits a stronger rejection response. Currently, VCA recipients are required to follow potent and lifelong immunosuppressing regimens to maximize graft survival. This puts patients at risk for malignancies, opportunistic infections, and cancers, thereby posing a need for less perilous methods of inducing graft tolerance. This review will provide an overview of cell populations and mechanisms, specific tissue involved in VCA rejection, as well as an updated scope of current methods of tolerance induction.

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Minimally and Non-invasive Approaches to Rejection Identification in Vascularized Composite Allotransplantation

Cited by 2 publications

References 36 publications

Case Report: Post-transplant lymphoproliferative disorder as a serious complication of vascularized composite allotransplantation

Case Report: Post-transplant lymphoproliferative disorder as a serious complication of vascularized composite allotransplantation

Immunogenicity and tolerance induction in vascularized composite allotransplantation

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