Immunogenicity and tolerance induction in vascularized composite allotransplantation
Jiahui (Angela) Sun,
Aisha Adil,
Felor Biniazan
et al.
Abstract:Vascularized composite allotransplantation (VCA) is the transplantation of multiple tissues such as skin, muscle, bone, nerve, and vessels, as a functional unit (i.e., hand or face) to patients suffering from major tissue trauma and functional deficits. Though the surgical feasibility has been optimized, issues regarding graft rejection remains. VCA rejection involves a diverse population of cells but is primarily driven by both donor and recipient lymphocytes, antigen-presenting cells, macrophages, and other … Show more
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