Minimal Recruitment and Activation of Dendritic Cells Within Renal Cell Carcinoma

Dendritic cells, T-cell infiltration, and grp94 expression in cholangiocellular carcinoma

“…[15][16][17][18] Bell et al 19 reported that in breast carcinoma immature DCs reside within the tumor, whereas mature DCs are located in peritumoral areas. Suzuki et al 20 reported that in the invasive margin of colorectal cancer stroma, mature CD83-positive DCs form clusters with T cells to promote T-cell activation for the generation of tumor-specific immunity.…”

Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers

“…L-Arginine depletion (Ochoa et al, 2007;Rodriguez et al, 2009;Zea et al, 2005) and the overproduction of ROS (Kusmartsev et al, 2008) are only two proven mechanisms of MDSC-induced immunosuppression in human RCC. Several studies have assessed the DC biology in RCC, and some agree that these cells can be found in two main locations: tumor stroma isolated from other immune cells or within lymphocyte aggregates in the IM of the tumor Troy, Summers, Davidson, Atkinson, & Hart, 1998). Interestingly, these two types of DCs display different phenotypes and capacities of T-cell priming, presumably due to the distinctive microenvironments in which they develop.…”

“…Isolated DCs display an immature phenotype (CD80 À , CD86 À , CD83 À , and HLA-DR À ) (Gigante et al, 2009;Giraldo et al, 2015), express tumor-promoting molecules (eg, TNF-α and MMP-9) (Figel et al, 2011), and induce a dysfunctional in vitro T-cell activation (Cabillic et al, 2006;Figel et al, 2011). On the other hand, DCs within immune aggregates exhibit a mature phenotype and express activation markers Middel, Brauneck, Meyer, & Radzun, 2010;Troy et al, 1998) (Fig. 4).…”

Human renal cell carcinoma inhibits dendritic cell maturation and functions

“…Dendritic cells (DC) play a crucial role in the initiation and development of specific immune responses, including antitumor T cell response [5,6], and increased infiltration of primary tumor lesions with DC has been associated with improved survival [7,8]. Furthermore, analysis of RCC for DC infiltration revealed that DC do not appear to be actively recruited into sites of RCC and the DC that were present within RCC tumors were minimally activated and exhibited poor T cell stimulatory activity [9,10]. Since the antitumor activity of DC depends on their functions, including adhesion, migration, and chemotaxis, the goal of present study was to determine whether RCC Gould modulate these key functions of DC in vitro.…”