Human renal cell carcinoma inhibits dendritic cell maturation and functions

Song, Eunice; Shurin, Michael R.; Tourkova, Irina L.; Chatta, Gurkamal S.; Shurin, Galina V.

doi:10.1007/s00120-004-0599-1

Cited by 10 publications

(6 citation statements)

References 14 publications

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“…Nevertheless, it seems possible that it could be induced by an inflammatory microenvironment. Indeed, previous reports have described that the presence of inflammatory cytokines such as TNF‐α, TGF‐β, IL‐6, IL‐8, G‐CSF, and VEGF can both recruit and induce tolerogenic DC and/or block in situ their differentiation in RCC . In addition, the fact that this population lies close to CD34 + blood vessels, and not PNAd + HEV, suggests they are potentially recruited from the systemic circulation, probably by similar mechanisms, as those described for monocytes .…”

Section: Compartmentalization and Tls In Ccrccmentioning

confidence: 67%

Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers

Dieu-Nosjean

Giraldo

Kaplon

et al. 2016

Immunological Reviews

299

243

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The characterization of the microenvironment of human tumors led to the description of tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T-cell zone adjacent to B-cell follicle including a germinal center. TLS represent sites of lymphoid neogenesis that develop in most solid cancers. Analysis of the current literature shows that the TLS presence is associated with a favorable clinical outcome for cancer patients, regardless of the approach used to quantify TLS and the stage of the disease. Using several approaches that combine immunohistochemistry, gene expression assays, and flow cytometry on large series of lung tumors, our work demonstrated that TLS are important sites for the initiation and/or maintenance of the local and systemic T- and B-cell responses against tumors. Surrounded by high endothelial venules, they represent a privileged area for the recruitment of lymphocytes into tumors and generation of central-memory T and B cells that circulate and limit cancer progression. TLS can be considered as a novel biomarker to stratify the overall survival risk of untreated cancer patients and as a marker of efficient immunotherapies. The induction and manipulation of cancer-associated TLS using drug agonists and/or biotherapies should open new avenues to treat cancer patients.

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Section: Compartmentalization and Tls In Ccrccmentioning

confidence: 67%

Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers

Dieu-Nosjean

Giraldo

Kaplon

et al. 2016

Immunological Reviews

299

243

View full text Add to dashboard Cite

show abstract

“…This evidence suggests that RCC microenvironment is enriched in molecules that hamper DC activity and maturation, since their phenotypic abnormalities are restricted to cells embedded in the tumor stroma and can be reversed when they are removed from the tumor. In addition, conditioned media from RCC primary cultures or cell lines can induce in vitro tolerogenic and dysfunctional DCs (HLA-DR dim , CD80 À /CD86 À , IL-10 + /TGF-β + ) Song, Shurin, Tourkova, Chatta, & Shurin, 2004;Teng et al, 2014) by mechanisms dependent on IL-6, IL-8, and VEGF (Cabillic et al, 2006;Figel et al, 2011).…”

Section: The Ccrcc Tumor Microenvironmentmentioning

confidence: 99%

Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers

Becht¹,

Giraldo²,

Germain³

et al. 2016

Advances in Immunology

176

136

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“…In addition, the apoptotic rate of TIDCs in endometrioid adenocarcinoma has been reported to be significantly higher than that in normal endometrium 39. Lower generation of human CD34-derived and CD14-derived DCs in cancer patients and also murine bone marrow-derived DCs in tumor-bearing mice, as well as a significant decrease in the number of circulating DCs in the peripheral blood of cancer patients have been repetitively reported 40-49.…”

Section: Tumor-induced Apoptosis Of Dendritic Cellsmentioning

confidence: 99%

Dendritic Cells in the Cancer Microenvironment

Shurin²,

et al. 2013

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The complexity of the tumor immunoenvironment is underscored by the emergence and discovery of different subsets of immune effectors and regulatory cells. Tumor-induced polarization of immune cell differentiation and function makes this unique environment even more intricate and variable. Dendritic cells (DCs) represent a special group of cells that display different phenotype and activity at the tumor site and exhibit differential pro-tumorigenic and anti-tumorigenic functions. DCs play a key role in inducing and maintaining the antitumor immunity, but in the tumor environment their antigen-presenting function may be lost or inefficient. DCs might be also polarized into immunosuppressive/tolerogenic regulatory DCs, which limit activity of effector T cells and support tumor growth and progression. Although various factors and signaling pathways have been described to be responsible for abnormal functioning of DCs in cancer, there are still no feasible therapeutic modalities available for preventing or reversing DC malfunction in tumor-bearing hosts. Thus, better understanding of DC immunobiology in cancer is pivotal for designing novel or improved therapeutic approaches that will allow proper functioning of DCs in patients with cancer.

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Human renal cell carcinoma inhibits dendritic cell maturation and functions

Abstract: rough estimate due to the limited sophistication of the variables used. Future development of this model on a molecular level basis may provide us with an even more robust model.

Cited by 10 publications

References 14 publications

Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers

Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers

Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers

Dendritic Cells in the Cancer Microenvironment

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