Minimal Clinically Important Difference for the Ocular Surface Disease Index

Miller, Kenneth S.; Walt, John G.; Mink, David R.; Satram‐Hoang, Sacha; Wilson, Steven E.; Perry, Henry D.; Asbell, Penny A.; Pflugfelder, Stephen C.

doi:10.1001/archophthalmol.2009.356

Cited by 441 publications

(331 citation statements)

References 9 publications

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“…How much of this was regression to the mean and how much a development of new symptoms cannot be determined. Unlike prior studies, we did not observe associations between visual symptoms and optical aberrations, high baseline myopia, poor 24 The denominator is the number of patients in the analytical cohort who submitted questionnaires. b The denominator is the number of patients with a normal OSDI score at baseline who submitted a questionnaire at the postoperative time point (normal OSDI score at preoperative visit to worse-than-normal score at postoperative visit).…”

Section: Discussioncontrasting

confidence: 97%

Symptoms and Satisfaction of Patients in the Patient-Reported Outcomes With Laser In Situ Keratomileusis (PROWL) Studies

et al. 2017

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IMPORTANCE Patient-reported outcomes should be collected using validated questionnaires prior to and following laser in situ keratomileusis (LASIK) surgery.OBJECTIVE To report the frequency of patient-reported visual symptoms, dry eye symptoms, satisfaction with vision, and satisfaction with LASIK surgery in the Patient-Reported Outcomes With LASIK (PROWL) studies. DESIGN, SETTING, AND PARTICIPANTSThe PROWL-1 and PROWL-2 studies were prospective, observational studies conducted from September 13, 2011, to June 27, 2014. The PROWL-1 study was a single-military center study of 262 active-duty Navy personnel 21 to 52 years of age. The PROWL-2 study was a study of 312 civilians 21 to 57 years of age conducted at 5 private practice and academic centers. The LASIK surgery and the postoperative care were performed based on the usual practice and clinical judgment at the site. Participants completed a self-administered, web-based questionnaire, preoperatively and postoperatively at 1 and 3 months (the PROWL-1 and -2 studies) and at 6 months (the PROWL-2 study).EXPOSURES Participants underwent LASIK surgery for myopia, hyperopia, and/or astigmatism. MAIN OUTCOMES AND MEASURESVisual symptoms (double images, glare, halos, and/or starbursts), dry eye symptoms, participant satisfaction (with vision and LASIK surgery), and clinical measures (visual acuity, refractive error, and slitlamp and posterior segment eye examination findings) were assessed preoperatively and at 1, 3, and 6 months postoperatively.RESULTS A total of 262 participants were enrolled in the PROWL-1 study (mean [SD] age, 29.1 [6.1] years), and a total of 312 participants were enrolled in the PROWL-2 study (mean [SD] age, 31.5 [7.3] years). Visual symptoms and dissatisfaction with vision were common preoperatively. Overall, the prevalence of visual symptoms and dry eye symptoms decreased, although a substantial percentage of participants reported new visual symptoms after surgery (43% [95% CI, 31%-55%] from the PROWL-1 study and 46% [95% CI, 33%-58%] from the PROWL-2 study at 3 months). The percentages of participants in the PROWL-1 study with normal Ocular Surface Disease Index scores were 55% (95% CI, 48%-61%) at baseline, 66% (95% CI, 59%-72%) at 3 months, and 73% (95% CI, 67%-79%) at 6 months. The percentages of participants in the PROWL-2 study with normal Ocular Surface Disease Index scores were 44% (95% CI, 38%-50%) at baseline and 65% (95% CI, 59%-71%) at 3 months. Of those participants who had normal scores at baseline in both the PROWL-1 and -2 studies, about 28% (95% CI, 19%-37%) had mild, moderate, or severe dry eye symptoms at 3 months. While most participants were satisfied, the rates of dissatisfaction with vision ranged from 1% (95% CI, 0%-4%) to 4% (95% CI, 2%-7%), and the rates of dissatisfaction with surgery ranged from 1% (95% CI, 0%-4%) to 2% (95% CI, 1%-5%). CONCLUSIONS AND RELEVANCEThe systematic administration of a questionnaire to patients who have undergone LASIK surgery is a new approach to assess symptoms and satisfaction. Our findi...

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Section: Discussioncontrasting

confidence: 97%

Symptoms and Satisfaction of Patients in the Patient-Reported Outcomes With Laser In Situ Keratomileusis (PROWL) Studies

et al. 2017

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“…Subjects evaluated in this study represent mild-to-moderate dry eye rather than severe dry eye. 61,62 No correlations between dry eye symptoms and conjunctival and corneal staining, as well as bulbar and limbal hyperaemia, were observed in this cohort of marginal dry eye patients. These findings are in accordance with current literature, where the poor relationships between ocular signs and dry eye symptoms are criticised.…”

Section: Discussionmentioning

confidence: 60%

The relationship between clinical signs and dry eye symptoms

Pult

Purslow

Murphy

2011

Eye

142

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Purpose To evaluate (i) the relationship between traditional and new clinical tests (lid-wiper epitheliopathy (LWE), lid-parallel conjunctival folds (LIPCOF)) and dry eye symptoms in non-contact lens wearers, and (ii) that a combination of these tests can improve predictive ability for the development of dry eye symptoms. Methods Tear meniscus height (TMH), non-invasive break-up time (NIBUT), ocular hyperaemia, LIPCOF, phenol red thread test (PRTT), corneal and conjunctival staining, and LWE grades were observed in a cohort of 47 healthy, non-lens wearers (male ¼ 17, female ¼ 30, median age ¼ 35 years, range ¼ 19-70). Symptoms were assessed using the Ocular Surface Disease Index (OSDI). Results LWE was significantly correlated to both temporal and nasal LIPCOF (0.537or o0.607, Po0.05). LIPCOF and LWE were significantly correlated to NIBUT and PRTT (r4À0.248, Po0.001). Significant correlations were found between NIBUT and TMH (r ¼ 0.461, P ¼ 0.001) and PRTT (r ¼ 0.640, Po0.001). OSDI scores were significant correlated to NIBUT, TMH, PRTT, LIPCOF, and LWE (r4|0.31|; Po0.05). Significant discriminators of OSDI þ /À were NIBUT (area under the receiver operative characteristic curve (AUC) ¼ 0.895), TMH (0.715), PRTT (0.781), LIPCOF (temporal/nasal/Sum 0.748/0.828/0.816), and LWE (0.749). Best predictive ability was achieved by combining NIBUT with nasal LIPCOF (AUC ¼ 0.944). Conclusions The individual tests NIBUT, TMH, PRTT, LIPCOF, and LWE were significantly, but moderately, related to OSDI scores. The strongest relationship appeared by combining NIBUT with nasal LIPCOF.

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“…This method was repeated three times for each eye, and the average of the results was registered as the mean TBUT. 12 TBUT of o10 s was accepted as abnormal.…”

Section: Methodsmentioning

confidence: 99%

“…The symptoms were assessed by the ocular surface disease index (OSDI; Allergan, Irvine, CA, USA) questionnaire. 12 The OSDI consists of 12 questions on symptoms within the past week and yields scores ranging from 0 (least severe) to 100 (most severe). A score of 12 is typically used as a cutoff for normal, 13-22 for mild dry eye, 23-32 for moderate dry eye, and ≥ 33 for severe dry eye.…”

Section: Introductionmentioning

confidence: 99%

The association of vitamin D deficiency with tear break-up time and Schirmer testing in non-Sjögren dry eye

Kurtul

Ozer

Aydinli

2015

Eye

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Purpose To investigate the effect of vitamin D deficiency on tear break-up time (TBUT) and Schirmer test scores and to assess their relationship in non-Sjögren dry-eye patients. Methods Thirty-four patients with serum vitamin D deficiency and 21 control subjects with normal vitamin D levels were included in this study. The TBUT and Schirmer-1 test without topical anesthesia were performed to all patients. Results The mean TBUT were 5.18 ± 2.15 and 7.36 ± 3.10 s and Schirmer scores were 12.18 ± 6.44 and 18.57 ± 8.99 mm in the study and control groups, respectively. TBUT scores and Schirmer-1 results of the study group were significantly lower than the control group (P = 0.01 and 0.007, respectively). The mean vitamin D levels were 11.50 ± 1.8 ng/ml in the study group and 32.8 ± 8.72 ng/ml in control group (P = 0.001). Dry-eye symptoms were detected in all patients in the study group and 15% of the patients in the control group. Conclusions We demonstrated that vitamin D deficiency decreases the TBUT and Schirmer test values and may be associated with dry-eye symptoms in non-Sjögren syndrome.

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Minimal Clinically Important Difference for the Ocular Surface Disease Index

Cited by 441 publications

References 9 publications

Symptoms and Satisfaction of Patients in the Patient-Reported Outcomes With Laser In Situ Keratomileusis (PROWL) Studies

Symptoms and Satisfaction of Patients in the Patient-Reported Outcomes With Laser In Situ Keratomileusis (PROWL) Studies

The relationship between clinical signs and dry eye symptoms

The association of vitamin D deficiency with tear break-up time and Schirmer testing in non-Sjögren dry eye

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