Miniaturized high-performance liquid chromatography instrumentation

Lynch, Kyle B.; Chen, Apeng; Liu, Shaorong

doi:10.1016/j.talanta.2017.09.016

Cited by 65 publications

(31 citation statements)

References 153 publications

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“…Still, the few groups that have been pursuing this have made good demonstration of the potential in working at high pressures. [6][7][8][9][10] In inertial focusing, it is generally accepted that in a straight channel, the migration and equilibrium of particles are mainly due to two forces; the shear gradient lift force, directed towards the walls of the channel and originated from the non-zero curvature of the flow profile, and the wall force, repelling particles from the walls and originated from the interaction of the stresslet around the particle and the wall. Reviews on the phenomenon can be found elsewhere, [11][12][13][14] but an introduction with key points is included in the following paragraphs to ease the understanding of the results and discussion.…”

Section: Introductionmentioning

confidence: 99%

Inertial focusing with sub-micron resolution for separation of bacteria

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Inertial focusing with sub-micron resolution for separation of bacteria

et al. 2019

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“…Although this effect is marginally reduced by programming the pumps 180° out of phase from one another, pulsations persist. The pump arrangement adopted in Minichrom [55] allows a lower flow rate range for the pump [139]. Low LODs were achieved for phenol (0.2 ppm) and anthracene (0.015 ppm) demonstrating the sensitivity of the system.…”

Section: Tulchinsky St Angelo (1998)mentioning

confidence: 99%

“…Flow rate fluctuations remains the main limitation to the commercialisation of EOP-based portable devices. Variations can arise from unstable voltage sources, and chemical breakdown within the pumping element [139]. Despite this, since EOPs do not contain moving parts, one could expect a degree of resilience to mechanical damage.…”

Section: Ishida Et Al (2015)mentioning

confidence: 99%

A Review of Portable High-Performance Liquid Chromatography: the Future of the Field?

et al. 2020

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There is a growing need for chemical analyses to be performed in the field, at the point of need. Tools and techniques often found in analytical chemistry laboratories are necessary in performing these analyses, yet have, historically, been unable to do so owing to their size, cost and complexity. Technical advances in miniaturisation and liquid chromatography are enabling the translation of these techniques out of the laboratory, and into the field. Here we examine the advances that are enabling portable liquid chromatography (LC). We explore the evolution of portable instrumentation from its inception to the most recent advances, highlighting the trends in the field and discussing the necessary criteria for developing in-field solutions. While instrumentation is becoming more capable it has yet to find adoption outside of research.

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“…The flow inside microchannels can be induced in two main methods; one is by using an external pump, such as a syringe pump or an high performance liquid chromatography (HPLC) pump [8], while another is utilizing centrifugal forces in a disc-shaped platform. In such a design, microfluidic features, known as "chambers", contain the sample fluid, while other features, known as "channels", connect different chambers and act as a passage for fluids inside the disc.…”

Section: Introductionmentioning

confidence: 99%

High-Efficiency Small Sample Microparticle Fractionation on a Femtosecond Laser-Machined Microfluidic Disc

et al. 2020

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The fabrication and testing of microfluidic spinning compact discs with embedded trapezoidal microchambers for the purpose of inertial microparticle focusing is reported in this article. Microparticle focusing channels require small features that cannot be easily fabricated in acrylic sheets and are complicated to realize in glass by traditional lithography techniques; therefore, the fabrication of microfluidic discs with femtosecond laser ablation is reported for the first time in this paper. It could be demonstrated that high-efficiency inertial focusing of 5 and 10 µm particles is achieved in a channel with trapezoidal microchambers regardless of the direction of disc rotation, which correlates to the dominance of inertial forces over Coriolis forces. To achieve the highest throughput possible, the suspension concentration was increased from 0.001% (w/v) to 0.005% (w/v). The focusing efficiency was 98.7% for the 10 µm particles and 93.75% for the 5 µm particles.

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Miniaturized high-performance liquid chromatography instrumentation

Cited by 65 publications

References 153 publications

Inertial focusing with sub-micron resolution for separation of bacteria

Inertial focusing with sub-micron resolution for separation of bacteria

A Review of Portable High-Performance Liquid Chromatography: the Future of the Field?

High-Efficiency Small Sample Microparticle Fractionation on a Femtosecond Laser-Machined Microfluidic Disc

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