Miniature mass spectrometer equipped with electrospray and desorption electrospray ionization for direct analysis of organics from solids and solutions

Sokol, Ewa; Noll, Robert J.; Cooks, R. Graham; Beegle, L. W.; Kim, Hugh I.; Kanik, I.

doi:10.1016/j.ijms.2010.10.019

Cited by 50 publications

(51 citation statements)

References 60 publications

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“…57 Other environmentally relevant analytes – amines, nitro compounds, and fluorinated compounds as well as other small organics - have been detected using the Mini 10 with a variety of non-ambient ionization techniques (ESI, DESI, electrosonic spray ionization, APCI, and membrane inlet with electron impact). 15,62,253 …”

Section: Practical Applicationsmentioning

confidence: 99%

Miniature and Fieldable Mass Spectrometers: Recent Advances

et al. 2015

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Section: Practical Applicationsmentioning

confidence: 99%

Miniature and Fieldable Mass Spectrometers: Recent Advances

et al. 2015

Self Cite

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“…The overall instrument uses 65 W average power and weighs G10 kg. The mass analyzer is a rectilinear ion trap (RIT) [50] operating at a frequency of 1 MHz enclosed in a stainless steel manifold of 470 cm 3 volume [51]. As a result of its simplified geometry and pressure tolerance, RITs have several advantages for miniaturization evidenced in previous applications [52].…”

Section: Dapci Ms Using a Miniature Mass Spectrometermentioning

confidence: 99%

Analysis of Polycyclic Aromatic Hydrocarbons Using Desorption Atmospheric Pressure Chemical Ionization Coupled to a Portable Mass Spectrometer

Jjunju

Maher

et al. 2014

J. Am. Soc. Mass Spectrom.

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Abstract. Desorption atmospheric pressure chemical ionization (DAPCI) is implemented on a portable mass spectrometer and applied to the direct detection of polycyclic aromatic hydrocarbons (PAHs) and alkyl substituted benzenes. The presence of these compounds in the environment poses a significant threat to the health of both humans and wildlife because of their carcinogenic, toxic, and mutagenic properties. As such, instant detection outside of the laboratory is of particular importance to allow in-situ measurement at the source. Using a rapid, high throughput, miniature, handheld mass spectrometer, several alkyl substituted benzenes and PAHs (i.e., 1,2,3,5-tetramethylbenzene, pentamethylbenzene, hexamethylbenzene, fluoranthene, anthracene, benzo[k]fluoranthene, dibenz [a,h]anthracene, acenaphthene, indeno [1,2,3-c,d]pyrene, 9-ethylfluorene, and 1-benzyl-3-methyl-naphthalene) were identified and characterized using tandem mass spectrometry (MS/MS) from ambient surfaces, in the open air. This method can provide almost instantaneous information while minimizing sample preparation, which is advantageous in terms of both cost and simplicity of analysis. This MS-based technique is applicable to a wide range of environmental organic molecules.

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“…Although ion transfer could be achieved by increasing the gas flow rate and by utilizing much larger and powerful vacuum pumps, the size and power consumption of the MS instrument will suffer correspondingly. [50][51][52][53] In spite of these advantages, the use of a mechanical switch to control vacuum pressure and ion introduction duration lowers the scan speed, 13,47 stability, robustness of the system, especially when used in some on-site applications involving harsh environments. In a DAPI setup, high gas flow rate and efficient ion transfer are realized by mechanically opening the API for a very short duration (on the scale of milli-seconds).…”

Section: Introductionmentioning

confidence: 99%

Development of a miniature mass spectrometer with continuous atmospheric pressure interface

Zhai

Feng

Wei

et al. 2015

Analyst

104

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The demand for on-the-spot analysis is met by a miniature mass spectrometer which is preferred to be robust, stable, as small as possible and capable of analyzing different samples by coupling with various ionization methods. However, largely constrained by the atmospheric pressure interface (API), these aspects are difficult to be realized in one system. Herein, we describe the development of a new miniature mass spectrometer with balanced performance. The miniature mass spectrometer is small in size (30 × 30 × 18 cm) but has a continuous API, which was achieved by high-pressure ion trap operation and maximized ion transfer efficiency with the utilization of a differential pumping system. The miniature mass spectrometer was characterized and optimized in terms of stability, sensitivity, mass range, mass resolution and scan speed. Rapid analysis of mixtures was demonstrated by coupling the miniature mass spectrometer with the ambient ionization technique of paper spray. This is the smallest miniature mass spectrometer to date, which has a continuous API.

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Miniature mass spectrometer equipped with electrospray and desorption electrospray ionization for direct analysis of organics from solids and solutions

Cited by 50 publications

References 60 publications

Miniature and Fieldable Mass Spectrometers: Recent Advances

Miniature and Fieldable Mass Spectrometers: Recent Advances

Analysis of Polycyclic Aromatic Hydrocarbons Using Desorption Atmospheric Pressure Chemical Ionization Coupled to a Portable Mass Spectrometer

Development of a miniature mass spectrometer with continuous atmospheric pressure interface

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