Miniature, high-resolution, quadrupole mass-spectrometer array

Orient, O. J.; Chutjian, A.; Garkanian, V.

doi:10.1063/1.1147947

Cited by 87 publications

(81 citation statements)

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“…In many types of mass spectrometers, the signal-to-noise ratio increases considerably by analyte accumulation, and the linear ion trap (LIT) concept has been widely used for ion accumulation in hybrid instruments [1][2][3][4][5][6][7]. The LIT has been suitable for the construction of miniature mass analyzers, gas-phase reactions, atomic spectroscopy, precursor fragmentation, and beam physics experiments [8][9][10][11][12][13][14][15][16]. In the case of quadrupole LIT, it can perform ion trapping and mass analysis, all in a single package [17].…”

mentioning

confidence: 99%

Computer simulation of the gap-tripole ion trap with linear injection, 3D ion accumulation, and versatile packet ejection

Salazar

Masujima

2008

J. Am. Soc. Mass Spectrom.

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The behavior of a completely new ion trap is shown with SIMION 7.0 simulations. The simulated trap, which was a mix of a linear and a 3D trap, was made by axially setting two ion guides with a gap between them. Each guide consisted of three rods with three symmetrically delayed radio frequency (rf) voltages (tripole). The "injected" ions were linearly contained by pulsed potentials on the entrance and exit plates. Then the three-dimensional (3D) rf field in the gap, which was created by the tripole special rod arrangement, could trap the ions when the translational energy was dampened by collisions with low-pressure nitrogen. Because the injected ions were trapped in the small gap, the trapping cycle could be repeated many times before ion ejection, so a high concentrated ion cloud could be obtained. This trapping and accumulation methodology is not possible in most conventional multipole linear traps with even number of poles. Compared with quadrupole linear trap at the same rf amplitude, tripole lost more ions due to strong charge repulsion in the ion cloud. However, tripole could catch up the ions at higher voltage. Radial and axial mass-independent ejection of the ions localized in the tripole gap was very simple, compared with conventional linear ion traps that need extra and complicated electrodes for effective axial ejection. F or analytical sciences, high sensitivity is one of the key points for success. In many types of mass spectrometers, the signal-to-noise ratio increases considerably by analyte accumulation, and the linear ion trap (LIT) concept has been widely used for ion accumulation in hybrid instruments [1][2][3][4][5][6][7]. The LIT has been suitable for the construction of miniature mass analyzers, gas-phase reactions, atomic spectroscopy, precursor fragmentation, and beam physics experiments [8][9][10][11][12][13][14][15][16]. In the case of quadrupole LIT, it can perform ion trapping and mass analysis, all in a single package [17]. The LIT is considered to have higher trapping efficiency and capacity than conventional 3D quadrupole ion trap (3D QIT or Paul Trap). The trapping efficiency for LIT is very high (~100%) compared with the 5% range for QIT when high-speed ions are externally injected [2,18,19]. Compared with the 3D QIT, space-charge repulsion is minimized in LIT because the charges can be dispersed in its big central volume.We have proposed a new ion optics, called "tripole" which consists of three parallel rods, carrying three rf voltages with symmetrically delayed phase shifts [20]. The rotating electric field of the tripole showed stable ion guiding for wide ranges of AC amplitude, better Address reprint requests to Dr. T. Masujima, Analytical Molecular Medicine and Devices Laboratory, Faulty of Frontier Medical Sciences, Graduate School of Hiroshima University, 1-2-3 Kasumi, Minarni-ku, Hiroshima 734-8551, Japan. E-mail: tsutomufehiroshima-u.ac.jp collisional focusing than hexapole and octapole, and similar focusing as quadrupole (rod pole). Also, the ion optic showed interest...

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confidence: 99%

Computer simulation of the gap-tripole ion trap with linear injection, 3D ion accumulation, and versatile packet ejection

Salazar

Masujima

2008

J. Am. Soc. Mass Spectrom.

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“…The ISS uses a version of the Viking mass spectrometer referred to as the Major Constituent Analyzer (MCA) to measure atmosphere components such as oxygen, carbon dioxide, and methane [61]. The technology under consideration for a future MCA includes the miniature ion trap [62] and quadrupole array instruments [13][14][15][16]. The main advantage of the miniaturized MCA, beside the obvious savings in resources, is the ability to place one of these instruments in each module, providing redundancy and more accurate in situ readings.…”

Section: International Space Stationmentioning

confidence: 99%

“…These include time-of-flight (TOF) [8,9], sector instruments [10 -12], quadrupole arrays [13][14][15][16], quadrupole ion traps [17], and cylindrical ion trap mass spectrometers [18 -20]. In addition to the two main space applications of MS, which are discussed in detail here, MS has also been used for other specialized space-related applica-tions.…”

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Mass spectrometry in the U.S. space program: Past, present, and future

Palmer

Limero

2001

J. Am. Soc. Mass Spectrom.

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Recent years have witnessed significant progress on the miniaturization of mass spectrometers for a variety of field applications. This article describes the development and application of mass spectrometry (MS) instrumentation to support of goals of the U.S. space program. Its main focus is on the two most common space-related applications of MS: studying the composition of planetary atmospheres and monitoring air quality on manned space missions. Both sets of applications present special requirements in terms of analytical performance (sensitivity, selectivity, speed, etc.), logistical considerations (space, weight, and power requirements), and deployment in perhaps the harshest of all possible environments (space). The MS instruments deployed on the Pioneer Venus and Mars Viking Lander missions are reviewed for the purposes of illustrating the unique features of the sample introduction systems, mass analyzers, and vacuum systems, and for presenting their specifications which are impressive even by today's standards. The various approaches for monitoring volatile organic compounds (VOCs) in cabin atmospheres are also reviewed. In the past, ground-based GC/MS instruments have been used to identify and quantify VOCs in archival samples collected during the Mercury, Apollo, Skylab, Space Shuttle, and Mir missions. Some of the data from the more recent missions are provided to illustrate the composition data obtained and to underscore the need for instrumentation to perform such monitoring in situ. Lastly, the development of two emerging technologies, Direct Sampling Ion Trap Mass Spectrometry (DSITMS) and GC/Ion Mobility Spectrometry (GC/IMS), will be discussed to illustrate their potential utility for future missions. (J Am Soc Mass Spectrom 2001, 12, 656 -675)

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“…Although the miniaturization of quadrupole filters has been challenging [24][25][26][27][28][29][30][31][32], compact single quadrupole instruments have now been developed [33,34], but so far there have been no attempts to extend the technology to a triple quadrupole. This is a potentially significant deficiency, as triple quadrupoles are preferred for some applications.…”

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A Microelectromechanical Systems-Enabled, Miniature Triple Quadrupole Mass Spectrometer

Wright¹,

Malcolm²,

Wright³

et al. 2015

Anal. Chem.

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Miniaturized mass spectrometers are becoming increasingly capable, enabling the development of many novel field and laboratory applications. However, to date, triple quadrupole tandem mass spectrometers, the workhorses of quantitative analysis, have not been significantly reduced in size. Here, the basis of a field-deployable triple quadrupole is described. The key development is a highly miniaturized ion optical assembly in which a train of six microengineered components are employed to generate ions at atmospheric pressure, provide a vacuum interface, effect ion guiding, and perform pre-filtering, fragmentation and mass analysis. Despite its small dimensions, the collision cell efficiently fragments precursor ions and yields product ion spectra that are very similar to those recorded using conventional instruments. The instrument has been used to detect Thiabendazole, a common pesticide, in apple pulp at a level of 10 ppb.3

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Miniature, high-resolution, quadrupole mass-spectrometer array

Cited by 87 publications

References 3 publications

Computer simulation of the gap-tripole ion trap with linear injection, 3D ion accumulation, and versatile packet ejection

Computer simulation of the gap-tripole ion trap with linear injection, 3D ion accumulation, and versatile packet ejection

Mass spectrometry in the U.S. space program: Past, present, and future

A Microelectromechanical Systems-Enabled, Miniature Triple Quadrupole Mass Spectrometer

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