Miniature chicken ileal explant culture to investigate the inflammatory response induced by pathogen associated molecular patterns

Mátis, Gábor; Sebők, Csilla; Horváth, Dávid G.; Márton, Rege Anna; Mackei, Máté; Vörösházi, Júlia; Kemény, Ágnes; Neogrády, Zsuzsanna; Varga, Ilona; Tr&aacute;j, Patrik

doi:10.2139/ssrn.4685306

SSRN Journal

2024

DOI: 10.2139/ssrn.4685306

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Miniature chicken ileal explant culture to investigate the inflammatory response induced by pathogen associated molecular patterns

Gábor Mátis,

Csilla Sebők,

Dávid G. Horváth

et al.

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2024

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Immunomodulatory properties of chicken cathelicidin-2 investigated on an ileal explant culture

Mátis,

Tráj,

Hanyecz

et al. 2024

Vet Res Commun

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As the threat posed by antimicrobial resistance grows more crucial, the development of compounds that can replace antibiotics becomes increasingly vital. Chicken cathelicidin-2 (Cath-2) belongs to the group of Host Defense Peptides (HDPs), which could provide a feasible solution for the treatment of gastrointestinal infections in poultry. It is a small peptide produced by the heterophil granulocytes of chickens as part of the innate immune response, and its immunomodulatory activity has already been demonstrated in several cell types. In this study, the effects of Cath-2 on the intestinal immune response were examined using ileal explant cultures isolated from chicken. Regarding our results, Cath-2 displayed a potent anti-inflammatory effect as it alleviated the LTA-caused elevation of interleukin (IL)-6 and IL-2 concentrations, and that of the IFN-γ/IL-10 ratio, furthermore, it increased the concentration of IL-10, alleviating the LTA-evoked decreased level of the anti-inflammatory cytokine. Moreover, when applied alone, it elevated the concentrations of IL-6, CXCLi2, and IL-2, providing evidence of its complex immunomodulatory mechanisms. In summary, Cath-2 was able to modulate the immune response of the intestinal wall not only by reducing pro-inflammatory cytokine release, but also through immune stimulation, demonstrating that it has the ability to improve innate immunity via a complex mechanism that may make it a suitable candidate for the control of intestinal infections.

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Immunomodulatory properties of chicken cathelicidin-2 investigated on an ileal explant culture

Mátis,

Tráj,

Hanyecz

et al. 2024

Vet Res Commun

View full text Add to dashboard Cite

show abstract

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Miniature chicken ileal explant culture to investigate the inflammatory response induced by pathogen associated molecular patterns

Cited by 1 publication

References 17 publications

Immunomodulatory properties of chicken cathelicidin-2 investigated on an ileal explant culture

Immunomodulatory properties of chicken cathelicidin-2 investigated on an ileal explant culture

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