Mini Review on Therapeutic Profile of Phenoxy Acids and Thier Derivatives

Begum, Shaheen; Bharathi, K.; S.r.g, Prasad K.v.

doi:10.22159/ijpps.2016v8i10.5005

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…Phenoxy acids are unquestionably among the most significant functional groups in organic chemistry. They are present, among several other structures, in certain naturally occurring particles, synthesized polymers, peptides, and pharmaceutical agents [4][5][6][7]. The formation of phenoxy acid bonds was one of the most significant pharmaceutical synthesis transformations [8,9], taking into account a high percentage of all preliminary evaluation responses in industrial and medical applications laboratories as recently reported [10].…”

Section: Introductionmentioning

confidence: 92%

Synthesis, crystal structure elucidation, Hirshfeld surface analysis, 3D energy frameworks and DFT studies of 2-(4-fluorophenoxy) acetic acid

et al. 2021

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The compound 2-(4-fluorophenoxy) acetic acid was synthesized by refluxing, 4-fluoro-phenol as a starting material with ethyl chloroacetate in acetone as solvent. The compound crystallizes in the monoclinic crystal system with the space group P21/c. Crystal data for C8H7FO3, a = 13.3087(17) Å, b = 4.9912(6) Å, c = 11.6018(15) Å, β = 104.171(4)°, V = 747.21(16) Å3, Z = 4, T = 293(2) K, μ(CuKα) = 1.142 mm-1, Dcalc = 1.512 g/cm3, 8759 reflections measured (13.72° ≤ 2Θ ≤ 130.62°), 1246 unique (Rint = 0.0528) which were used in all calculations. The final R1 was 0.0458 (>2sigma(I)) and wR2 was 0.1313 (all data). The structure was stabilized by C-H···O and C-H···Cg interactions. The intermolecular interactions in the crystal were studied using Hirshfeld surface analysis. 3D energy frameworks were computed to visualize the packing modes. DFT calculations were performed. The FMOs were studied to estimate the kinetic stability and reactivity of the molecule. The MEP surface was generated to investigate the charge distribution and chemical reactive sites in the molecule.

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Section: Introductionmentioning

confidence: 92%

Synthesis, crystal structure elucidation, Hirshfeld surface analysis, 3D energy frameworks and DFT studies of 2-(4-fluorophenoxy) acetic acid

et al. 2021

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“…Phenoxy acetic acid is an organic compound that represents a group of phenoxy acetic acid derivatives containing anisole in which acetic acid or its derivatives are linked to the methane group Fig. 1 [ 40 ]. Phenoxy acetic acid is often known to be monocarboxylic acid, which is the glycolic acid O -phenyl derivative with a sweet and sour tasting with significant smells like honey and can be found in cocoa and its products.…”

Section: An Overview Of Phenoxy Derivatives As Possible Therapeutic Cmentioning

confidence: 99%

Recent investigations into synthesis and pharmacological activities of phenoxy acetamide and its derivatives (chalcone, indole and quinoline) as possible therapeutic candidates

2021

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Graphical abstract Medicinal chemistry can rightfully be regarded as a cornerstone in the public health of our modern society that combines chemistry and pharmacology with the aim of designing and developing new pharmaceutical compounds. For this purpose, many chemical techniques as well as new computational chemistry applications are used to study the utilization of drugs and their biological effects. In the biological interface, medicinal chemistry constitutes a group of interdisciplinary sciences, as well as controlling its organic, physical and computational pillars. Therefore, medicinal chemists working to design an integrated and developing system that portends an era of novel and safe tailored drugs either by synthesizing new pharmaceuticals or to improving the processes by which existing pharmaceuticals are made. It includes researching the effects of synthetic, semi-synthetic and natural biologically active substances based on molecular interactions in terms of molecular structure with triggered functional groups or the specific physicochemical properties. The present work focuses on the literature survey of chemical diversity of phenoxy acetamide and its derivatives (Chalcone, Indole and Quinoline) in the molecular framework in order to get complete information regarding pharmacologically interesting compounds of widely different composition. From a biological and industrial point of view, this literature review may provide an opportunity for the chemists to design new derivatives of phenoxy acetamide and its derivatives that proved to be the successful agent in view of safety and efficacy to enhance life quality.

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“…The results showed that these compounds have effective biological activity against organisms such as Enterococcus faecile, Salmonella typhi, and Escherichia coli. 40 Soraya Sepehrfar et al studied new Schiff base 2-amino 2-methyl-1-propanol derivate complexes and investigated by Hirshfeld surface analysis and molecular simulation against SARS-CoV-2. 41 Considering the importance of the synthesis of new compounds with new biological properties in the development of biological drugs, we have focused on the synthesis and properties of new compounds.…”

Section: Introductionmentioning

confidence: 99%

Novel dinuclear Ni (II) Schiff base complexes induced noncovalent exchanges: Crystal structure investigation, electrochemical assessment, Hirshfeld surface analysis and SARS‐CoV‐2 docking study

Roozbahani,

Malekshah,

Salehi

et al. 2023

Applied Organom Chemis

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In this work, novel Ni (II) complexes, namely, [Ni2(L)2(OAc)2(EtOH)2] (1a), [Ni2(L)2(OAc)2(H2O)2] (1b‐1) and [Ni2(L)2(OAc)2(EtOH)2] (1b‐2) as co‐crystal were synthesized by the 1:1 condensation (https://www.sciencedirect.com/topics/chemistry/condensation) of Ni (CH3COO)2·4H2O and Schiff base ligand (H2L) (2‐hydroxy‐4‐methoxybenzaldehyde and 2‐amino‐2‐methylpropanol). The ligand based on Schiff base and fabricated complexes (1a) and (1b‐1 and 1b‐2) were successfully identified by CHN assessment, FT‐IR, UV–Vis spectra, melting point and CV voltammogram. The electrochemical behavior investigation shows that the nickel complexes exhibited irreversible oxidation processes in methanol solution. Additionally, the crystal structures of complexes (1a) and (1b) have been recognized by single‐crystal X‐ray diffraction investigation. It turned out that the complexes (1b‐1) and (1b‐2) crystallize together, making a co‐crystal 1b with an additional EtOH solvent molecule in the crystal structure. A detailed study of intermolecular exchanges was performed using attractive graphical analysis tools such as three‐dimensional Hirshfeld surfaces analysis, two‐dimensional fingerprint plots (FPs), and enrichment ratios (E), which make C‐H … C, C‐H … O hydrogen bond, C … O, H … H, and O … O short contacts on Hirshfeld surfaces with color code are observed. Moreover, an appraisement of the inhibitory trace against coronavirus (main protease SARS‐CoV‐2, PDB ID: 6Y2F) and molecular targets of human angiotensin‐converting enzyme‐2 (ACE‐2) was performed by a molecular docking study in which two nickel complexes performed best for PDB protein ID: 6M0J and all three complexes for PDB protein ID: 6Y2F.

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Mini Review on Therapeutic Profile of Phenoxy Acids and Thier Derivatives

Cited by 8 publications

References 20 publications

Synthesis, crystal structure elucidation, Hirshfeld surface analysis, 3D energy frameworks and DFT studies of 2-(4-fluorophenoxy) acetic acid

Synthesis, crystal structure elucidation, Hirshfeld surface analysis, 3D energy frameworks and DFT studies of 2-(4-fluorophenoxy) acetic acid

Recent investigations into synthesis and pharmacological activities of phenoxy acetamide and its derivatives (chalcone, indole and quinoline) as possible therapeutic candidates

Novel dinuclear Ni (II) Schiff base complexes induced noncovalent exchanges: Crystal structure investigation, electrochemical assessment, Hirshfeld surface analysis and SARS‐CoV‐2 docking study

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