Mineralization of the central nervous system in pseudopseudohypoparathyroidism (PPH).

Dudley, Alden W.; Hawkins, H.F.

doi:10.1136/jnnp.33.2.147

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Since PHP can present with many varied symptoms, patients may present to practitioners for various consequences of the disease, including dermatology for cutaneous ossifications, paediatrics for childhood obesity and poor growth, endocrinology for hypothyroidism or hypogonadism, dentistry for dental abnormalities or neurology for neurological manifestations, so it is important that practitioners have a high level of suspicion for the disease, given the right clinical context 18––20. There are very few long-term studies examining patients with PHP.…”

Section: Common Presentations and Follow-upmentioning

confidence: 99%

Prolonged spontaneous normocalcaemia in pseudohypoparathyroidism from resorption of soft tissue calcium deposits: a cautionary tale

Carter

Kline

2014

BMJ Case Reports

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SUMMARYA 42-year-old man diagnosed with pseudohypoparathyroidism and Albright's hereditary osteodystrophy as an infant was lost to follow-up and remained, unmonitored, on calcitriol and calcium for over 20 years. He presented after having an ST-elevation myocardial infarction. In addition to coronary artery calcifications, he was found to have diffuse subcutaneous and joint calcifications. His calcium, phosphate and parathyroid hormone (PTH) levels were normal, and given the lack of prior documentation in the diagnosis he was instructed to discontinue calcitriol and calcium until further investigations were completed. Despite stopping the medication, his serum calcium remained normal for over 1 year. It was not until 18 months later, when his soft tissue calcium stores were depleted, that he finally developed symptomatic hypocalcaemia and an elevated PTH. This case not only emphasises the importance of long-term follow-up for patients with pseudohypoparathyroidism, but also highlights the potential complications of long-term, unmonitored, calcitriol use. BACKGROUND

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Section: Common Presentations and Follow-upmentioning

confidence: 99%

Prolonged spontaneous normocalcaemia in pseudohypoparathyroidism from resorption of soft tissue calcium deposits: a cautionary tale

Carter

Kline

2014

BMJ Case Reports

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“…The syndrome is rare and the few families described by previous workers (Roberts, 1959;Mathews, 1957) apparently varied considerably in the precise genetics of the condition. Another possibility is that she may, after all, be a case of pseudo-pseudohypoparathyroidism, and a recent review (Dudley & Hawkins, 1970) suggests that occasional patients with this condition develop mineralization of the globus pallidus and dentate nuclei with not only calcium deposited but also iron and trace elements such as phosphorus, zinc and cobalt. In this condition one sees the physical and mental changes of pseudohypoparathyroidism, i.e.…”

Section: Commentmentioning

confidence: 99%

Calcification of the basal ganglia apparently presenting as a schizophreniform psychosis

Hall¹

1972

Postgraduate Medical Journal

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Summary A patient with gross basal ganglia calcification is described, whose condition was associated with severe psychotic symptoms and in whom the clinical picture was not typical of hypoparathyroidism, pseudohypoparathyroidism or pseudo-pseudohypoparathyroidism. Calcification of the basal ganglia may occur in a variety of infections, toxic and metabolic disorders, particularly hypoparathyroidism, pseudohypoparathyroidism, toxoplasmosis and some anoxic conditions (Moskowitz, Winickoff & Heinz, 1971). Though there is doubt as to the precise diagnosis in the present case, familial calcification appears to be the most probable.

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Pseudopseudohypoparathyroidism With Fibrous Dysplasia

Solomon¹

1975

Arch Dermatol

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Mineralization of the central nervous system in pseudopseudohypoparathyroidism (PPH).

Cited by 5 publications

References 28 publications

Prolonged spontaneous normocalcaemia in pseudohypoparathyroidism from resorption of soft tissue calcium deposits: a cautionary tale

Prolonged spontaneous normocalcaemia in pseudohypoparathyroidism from resorption of soft tissue calcium deposits: a cautionary tale

Calcification of the basal ganglia apparently presenting as a schizophreniform psychosis

Pseudopseudohypoparathyroidism With Fibrous Dysplasia

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