Calcification of the basal ganglia apparently presenting as a schizophreniform psychosis

Hall, Peter

doi:10.1136/pgmj.48.564.636

Cited by 10 publications

(3 citation statements)

References 4 publications

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“…Frontal subcortical dementia is thought to be the most usual type of dementia observed in IBGC. Reported psychiatric disturbances have been mainly schizophrenia-like psychoses (Cummings et al 1983;Chiu et al 1993;Hall 1972) or mood disturbances with either depression or mania (Trautner et al 1988). Associations have been reported between basal ganglia calcification and organic mood syndromes (Forstl et al 1991;Lopez-Villegas et al 1996), affective disorder (Forstl et al 1991), obsessive compulsive disorder (Lopez-Villegas et al 1996) and neurological and psychiatric symptoms generally (König 1989).…”

Section: Introductionmentioning

confidence: 98%

Familial idiopathic basal ganglia calcification (Fahr's disease) without neurological, cognitive and psychiatric symptoms is not linked to the IBGC1 locus on chromosome 14q

et al. 2001

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Idiopathic basal ganglia calcification (IBGC) is characterised by radiological, neurological, cognitive and psychiatric abnormalities. The associations between these abnormal phenotypes and abnormal genes remain unclear despite the recent mapping to chromosome 14q of a susceptibility locus for IBGC ( IBGC1). We identified two siblings, from a large multigenerational pedigree, who had both been diagnosed with radiological IBGC, dementia, bipolar affective disorder and Parkinsonism. We assessed (1) other family members to determine whether these four phenotypes were co-segregating as symptoms of IBGC, and (2) possible IBGC linkage to the IBGC1 locus on chromosome 14q or to any known or potential dementia genes. Nine second-generation and 21 third-generation members received radiological, neurological, neuropsychological and psychiatric assessments. We genotyped all family members for microsatellite markers at the IBGC1 locus and polymorphisms of the ApoE, VLDL, alpha1-ACT, BChE-K, APP, PS1, PS2 and tau genes and tested these for linkage to IBGC, dementia and bipolar disorder. Of the ten family members with radiological intracranial calcification, all except the two index cases were normal. There was no significant association between IBGC status and severe cognitive impairment or dementia ( P=0.335) or bipolar affective disorder or Parkinsonism ( P=1.0). Linkage to the IBGC1 locus was excluded. Of the eight dementia gene markers tested, the only positive LOD score was for the ApoE epsilon4 polymorphism and dementia/severe cognitive impairment. We have identified a form of IBGC in which calcification is inherited independently of neurological, cognitive and psychiatric symptoms. This may represent a second locus for this disorder.

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Section: Introductionmentioning

confidence: 98%

Familial idiopathic basal ganglia calcification (Fahr's disease) without neurological, cognitive and psychiatric symptoms is not linked to the IBGC1 locus on chromosome 14q

et al. 2001

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“…The claim for an association between psychosis and ICBG rests also on evidence from cases of sporadic ICBG, which may of course have a different aetiology from familial ICBG (assuming that there is no heterogeneity in the latter disorder). There are, indeed, a few well described cases, such as those of Cummings et al (1983) and Hall (1972). However, other reports give only the briefest descriptions of mental state, from which it is again difficult to be certain that the authors have ruled out confusional states.…”

Section: What Is the Relationship Between Familial Icbg And Mental DImentioning

confidence: 98%

Familial calcification of the basal ganglia: a case report and review of the literature

Flint

Goldstein

1992

Psychol. Med.

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SynopsisAlthough calcification of the basal ganglia is a relatively common and asymptomatic finding on cranial computed tomography, familial idiopathic calcification of the basal ganglia (ICBG) is a rare disorder with neurological and behavioural manifestations. Attention has recently been drawn to the frequency with which cases are diagnosed as schizophrenic (Cummings et al. 1983; Lowenthal, 1986; Davison, 1987). We report a family in which a mother and son have ICBG, but while the son has a paranoid schizophrenia and intellectual deterioration, the mother shows no psychiatric illness. A review of the relevant literature suggests that psychosis is not as common as usually supposed, and may only be coincidentally associated with familial ICBG. Moreover, we find little convincing evidence that familial ICBG is an independent entity; instead, and in agreement with earlier authorities (Bruyn et al. 1964), we argue that published accounts and our own cases provide evidence that the condition is related to pseudo-hypoparathyroidism (PHP) and, therefore, may be due to a defect in a guanine nucleotide binding protein.

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“…A presença do cisticerco no SNC ocasiona reação inflamatória localizada, crônica e fibrosante 10 . Produtos do metabolismo do parasito determinam essas reações locais que, sob forma de meningoencefalite crônica, podem determinar destruição neuronal, como no córtex cerebral 15,20,21.…”

Section: Comentáriosunclassified

Cisticercos calcificados em gânglios da base e síndrome Parkinsoniana: registro de um caso

Cavalcanti

1984

Arq. Neuro-Psiquiatr.

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It is reported the case of a 57 years-old man from Maranhão State who presented Parkinson's syndrome. Images proper to calcified cysticerci were found in the basal ganglia at the CT-scan examination. Considerations are made as to: the low frequency of cysticercosis in the northern region of the country where the patient lives; the association of symptomatic Parkinson's syndrome and cysticercosis of the central nervous system, which is rare; the demonstration of calcified cysticerci in basal ganglia in this situation, which was not registered up to the present time.

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Calcification of the basal ganglia apparently presenting as a schizophreniform psychosis

Cited by 10 publications

References 4 publications

Familial idiopathic basal ganglia calcification (Fahr's disease) without neurological, cognitive and psychiatric symptoms is not linked to the IBGC1 locus on chromosome 14q

Familial idiopathic basal ganglia calcification (Fahr's disease) without neurological, cognitive and psychiatric symptoms is not linked to the IBGC1 locus on chromosome 14q

Familial calcification of the basal ganglia: a case report and review of the literature

Cisticercos calcificados em gânglios da base e síndrome Parkinsoniana: registro de um caso

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