Mineralization of plasma treated polymer surfaces from super-saturated simulated body fluids

Effect of low-temperature plasma treatment of electrospun polycaprolactone fibrous scaffolds on calcium carbonate mineralisation

“…There are a number of reports on using plasma pre-treated PCL bers as an active substrate for biomimetic growth of the calcium phosphates. [47][48][49] For instance, Yang et al achieved a homogeneous coating of CaP coating onto polymer scaffolds aer Arplasma treatment and a long period (2-6 h and 7 days) of immersion in simulated body uid (SBF). 49 Lebourg et al reported the deposition of CaP layers grown on PCL treated with air plasma and subsequently immersed in SBF for 14 days.…”

“…50 As shown in ref. [47][48][49], the biomimetic CaP coating is formed by a mesh of interlocking of ack-like crystals, which allows to create an open microporosity. This structure is suitable for the short time drug administration, because the incorporated drug release is diffusion-controlled.…”

Effects of polydopamine coatings on nucleation modes of surface mineralization from simulated body fluid

“…This method is therefore particularly applicable to polymers of low melting temperatures such as PCL, PLGA which are not suitable for traditional CaP coating methods such as plasma (thermal) spraying 33,34 . A formulation of 10× SBF (pH 4.0) containing NaCl (58.43 g/L), KCl (0.373 g/L), CaCl 2 .2H2O (3.675 g/L), MgCl 2 .6H 2 O (1.016 g/L) and Na 2 HPO 4 (1.42 g/L) was used to accelerate the mineralization 13,24 . The pH of this 10× SBF was adjusted to 6 using NaHCO3 before substrates were placed into the solution and incubated at 37 °C for 5 min (the mineral nucleation stage) and 60 min (the complete mineralization group).…”

“…Mineralization started with nucleation on a substrate from the oversaturated solution containing calcium and phosphate ions, such as simulated body fluid and the nuclei continued to grow to eventually completely cover the substrate 12 . This nucleation-growth process can occur in one of the following 3 modes depending on the substrate-coating adhesion and coating cohesion energies [13][14][15][16][17][18] . For a coating that presents a coating-substrate adhesion energy significantly stronger than coating-coating cohesion energy, a planar growth mode (Frank-van der Merwe mode ) is dominant where a planar layer expands to cover the substrate.…”

“…A mixture of islanding and planar mode (Stranski-Krastanov mode) is also common in many systems. Experimentally, coating formation on hydrophobic surfaces occurs predominantly through "islands" whereas mixed islanding and planar modes (known as Stranski-Krastanov modes) occur on more hydrophilic surfaces 13,15,16 .…”