Mineral Trioxide Aggregate: A Comprehensive Literature Review—Part I: Chemical, Physical, and Antibacterial Properties

Parirokh, Masoud; Torabinejad, Mahmoud

doi:10.1016/j.joen.2009.09.006

Cited by 927 publications

(967 citation statements)

References 158 publications

(423 reference statements)

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“…MTA is a biocompatible material composed by PC added to 20% of bismuth oxide as radiopacifier 26) . In the present study, MTA showed 5 mmAl as radiopacity value, in accordance with previous studies 10) .…”

Section: Discussionmentioning

confidence: 99%

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Radiopacity, pH and antimicrobial activity of Portland cement associated with micro- and nanoparticles of zirconium oxide and niobium oxide

et al. 2014

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The aim of this study was to evaluate some properties of the calcium silicate materials Mineral Trioxide Aggregate (MTA) and Portland cement (PC) with microparticulated (micro) and nanoparticulated (nano) zirconium oxide (ZrO 2 ) or niobium oxide (Nb 2 O 5 ). The experimental materials: White PC (PC), MTA-Angelus ® (MTA), PC+ZrO 2 micro, PC+ZrO 2 nano, PC+Nb 2 O 5 micro and PC+Nb 2 O 5 nano were submitted to radiopacity and pH evaluations. Furthermore, the antimicrobial activity against different microorganisms was assessed by agar diffusion test. MTA presented higher radiopacity than other materials. However, all materials except PC presented higher radiopacity than recommended by ISO/ADA. MTA promoted higher pH values in all analyzed periods (p≤0.05). At the initial periods, PC and PC+ZrO 2 micro showed pH similar to MTA. All materials showed antimicrobial activity against the evaluated microorganisms. In conclusion, ZrO 2 and Nb 2 O 5 could be alternative radiopacifiers to be added to calcium silicate materials.

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Section: Discussionmentioning

confidence: 99%

“…The high pH value of MTA is attributed to the constant calcium release and calcium hydroxide formation. The antifungal effect of MTA might be due to its high pH and also to substances released from MTA 26) .…”

Section: Discussionmentioning

confidence: 99%

Radiopacity, pH and antimicrobial activity of Portland cement associated with micro- and nanoparticles of zirconium oxide and niobium oxide

et al. 2014

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“…Torabinejad & Parirokh 23 observed an initial pH of 10.2 for MTA, rising to 12.5 in 3h. It is known that pH levels in the order of 12.0 can inhibit a bigger amount of microrganisms, including resistant bacteria such as Enterococcus faecalis.…”

Section: Discussionmentioning

confidence: 97%

“…The MTA and Portland cement has similarities in their chemical composition, physical properties, biocompatibility and tissue response [5][6][7][8][9] . Therefore, the aim of this study was to evaluate the antimicrobial activity of MTA e PC against some selected cariogenic bacteria.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cariogenic antibacterial activity of mineral trioxide aggregate and Portland cement

Júnior

Sobral

Sampaio

et al. 2015

RGO, Rev. Gaúch. Odontol.

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ObjectiveThe objective of this study was to evaluate the antimicrobial activity of Mineral trioxide aggregate e Portland cement against some selected cariogenic bacteria. Methods Wells were made of approximately 0.5 mm in diameter, in solid culture media and immediately filled with cement. Twelve samples of each material were obtained for the realization of the agar diffusion method. These samples were tested with Streptococcus mutans (ATCC 700610), Enterococcus faecalis (ATCC 29212), Lactobacillus acidophilus (UFV) and Lactobacillus casei (UNICAMP). Petri plates containing Tripticase soy Agar (TSA) were used for the growth of Streptococcus mutans and Enterococcus faecalis, and plates of Man Rogosa & Sharpe Agar (MRS) for the Lactobacillus acidophilus and Lactobacillus casei. After 48 hours of incubation, it was made the measurement of inhibition halos with the aid of manual caliper. ResultsThe diameters obtained to MTA (2.50 ± 0.00;2,92 ± 0.63; 2.58 ± 0.38), PC (1.17 ± 0.29; 2.00 ± 0.43; 1.33 ± 0.14) and calcium hydroxide cement (3.83 ± 0.29; 3.00 ± 0.00 ± 2.58 ± 0.72) ResultadosOs diâmetros obtidos do MTA (2.50 ± 0.00; 2,92 ± 0.63; 2.58 ± 0.38), CP (1.17 ± 0.29; 2.00 ± 0.43; 1.33 ± 0.14) e cimento de hidróxido de cálcio (3.83 ± 0.29; 3.00 ± 0.00 ± 2.58 ± 0.72) foram expressos em milímetros e submetidos ao teste de Tukey (p<0.05). Conclusão METHODSThe tested materials were: MTA (Angelus Soluções Odontológicas, Londrina, Brasil), Portland cement (CP II -F32, ITAPESSOCA AGRO-INDUSTRIAL S.A., Goiana, Brasil) and calcium hydroxide paste (Reagen TM).The antimicrobial activity of the materials was evaluated by the Agar diffusion method against four different strains.The strains used for analysis were Streptococcus mutans (ATCC 700610), Enterococcus faecalis (ATCC 29212), Lactobacillus acidophilus and Lactobacillus casei isolated by the Laboratory of Microbiologic Science (Federal University of Viçosa -MG (UFV) and University State of Campinas -UNICAMP, SP, Brazil), respectively.Of each bacterial culture tested, it was held a concentration suspension of approximately 5x108 of colonies per mL, corresponding to 0.5 of Mc Farland em range of sterile medium Trypticase Soy Browth (TSBMerck). The Streptococcus mutans and Enterococcus faecalis suspensions were inoculated with spread plate in the middle of Sodium Tioglicolate (Merck) culture and Lactobacillus and Lactobacillus acidophilus casei were inoculated in the culture medium Man Rogosa & Sharpe Agar (MRS-HIMEDIA). Subsequently, the plates were incubated at 35 ± 1°C for 24/48h and the halos of inhibition were expressed in millimeters, using a caliper manual.A total of 12 plates were employed, each microorganism was tested in triplicate. Three cavities, measuring 4mm in diameter were made in each agar plate using a copper puncher and then completely filled with freshly manipulated product to be tested.Positive (CaOH) and negative controls (sterile growing medium) were tested using the same methodology and under the same conditions of the experiment.All cult...

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“…The major component, Portland cement is a mixture of dicalcium silicate, tricalcium silicate, tricalcium aluminate, gypsum, and tetracalcium aluminoferrite 2) . Early reports described antimicrobial activity of MTA 1,3) , however their level was very poor requiring until 50 mg/mL to inhibit the microbial growth. Failure in endodontic treatment is not weird and the usual factors for this are: persistence bacteria, inadequate filling of the canal, improper coronal seal, untreated canals, etc.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and antibiofilm activities of MTA supplemented with bismuth lipophilic nanoparticles

et al. 2017

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The objective of this work was to determine the antimicrobial and antibiofilm properties of mineral trioxide aggregate (MTA) supplemented with bismuth lipophilic nanoparticles (BisBAL NPs). The antimicrobial activity of the composite MTA-BisBAL NPs was determined by the disk diffusion assay, while antibiofilm activity was analyzed by fluorescence microscopy. The cytotoxicity of MTA-BisBAL NPs was determined on human gingival fibroblasts by optical microscopy and crystal violet staining. MTA-BisBAL NPs inhibited the growth of Enterococcus faecalis, Escherichia coli, and Candida albicans and also detached the biofilm of fluorescent E. faecalis after 24 h of treatment. The addition of BisBAL nanoparticles did not significantly modify the physical properties of MTA, and cytotoxicity was not observed when MTA-BisBAL NPs was added on human gingival fibroblasts. Altogether these results suggest that BisBAL nanoparticles provide antimicrobial and antibiofilm activities to MTA while it retained their biophysical properties without cause side effects on human gingival fibroblasts.

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Mineral Trioxide Aggregate: A Comprehensive Literature Review—Part I: Chemical, Physical, and Antibacterial Properties

Cited by 927 publications

References 158 publications

Radiopacity, pH and antimicrobial activity of Portland cement associated with micro- and nanoparticles of zirconium oxide and niobium oxide

Radiopacity, pH and antimicrobial activity of Portland cement associated with micro- and nanoparticles of zirconium oxide and niobium oxide

Evaluation of cariogenic antibacterial activity of mineral trioxide aggregate and Portland cement

Antimicrobial and antibiofilm activities of MTA supplemented with bismuth lipophilic nanoparticles

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