Mineral Metabolism in Relation to Acid-Base Equilibrium

Shohl, Alfred T.

doi:10.1152/physrev.1923.3.4.509

Cited by 28 publications

(7 citation statements)

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“…2 excretion in pigs following the administration of mineral acid, but not after feeding oxidizable organic acids. Shohl and Sato (7) showed that the feeding of hydrochloric acid decreased the storage of calcium by growing children, and demonstrated the reverse effect of sodium bicarbonate. These effects were also noted by Zucker (8).…”

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confidence: 99%

Studies of Calcium and Phosphorus Metabolism

Farquharson¹,

Salter²,

Tibbetts³

et al. 1931

J. Clin. Invest.

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In the course of our studies in calciulm metabolism evidence has steadily accumulated that the metabolism of acid-producing substances plays an important r6le in influencing the assimilation and excretion of calcium. This effect, however, has not been adequately studied in man, and in other studies of calcium exchange the potential acidity or alkalinity of foods and medication has largely been neglected.It is the purpose of the present investigation to follow the effect of food-stuffs and inorganic salts on calcium metabolism with relation to their potential acidity (after oxidation) referred to the hydrogen ion concentration of the blood.Studies in rickets for some time have indicated the importance of acidity to the assimilation and storage of inorganic salts in bone. Thus, McClendon (1) noted that the addition of alkali to a diet increased its power to produce rickets and, conversely, Zucker, Johnson, and Barnett (2) reported that the change in acidity of diets from the alkaline toward the acid side of neutrality might result in healing of the rachitic lesions.Much work, too, has been done upon the effect of administered acid on the mineral excretion. The experiments of Givens and Mendel (3) and of Givens (4) upon the effect of base and acid on the general metabolism tended to minimize variations in calcium excretion resulting from this factor. Subsequently, Goto (5), using rabbits, demonstrated depletion of the skeleton by repeated doses of hydrochloric acid. Lamb and Evvard (6) demonstrated increased urinary calcium

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confidence: 99%

Studies of Calcium and Phosphorus Metabolism

Farquharson¹,

Salter²,

Tibbetts³

et al. 1931

J. Clin. Invest.

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“…Copper Silicon Vanadium Zinc Boron Lithium Aluminium Titanium Strontium Manganese [1][2] The presence of rubidium has been confirmed by other methods (Wright and Papish (I.e.)). Fluorine has also been found (Richmond {I.e.)).…”

Section: R6le Of Minerals In Nutritionmentioning

confidence: 59%

12. The Mineral Requirements of Dairy Cattle

Crichton¹

1930

Journal of Dairy Research

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The most important fact brought out by a review of the present position of our knowledge of mineral metabolism and the mineral requirements in the dairy cow is, that, in spite of the amount of work which has been done on the subject, our information is exceedingly scanty. We know that deficiency of calcium or phosphorus may affect rate of growth, milk yield, breeding capacity, and in all probability susceptibility to certain diseases. We know also that even on what are counted good rations, depletion of the tissues, especially of calcium, in heavy milking cows during lactation is common. In some districts deficiency of iodine causes pathological conditions, and it is common knowledge based on practical observations that even on pasture there is liable to be a deficiency of chlorine. With regard to the possibility of deficiencies of other mineral elements and the effect of such deficiencies on the health and milk production of cows, we have not yet even begun to accumulate knowledge. It is thus impossible to make a final pronouncement with regard to any of the main problems. We need many more data on the metabolism of minerals in the lactating animal and on feeding experiments of long duration with rations of different mineral content. Such information as we have, however, suggests that the subject is one of great potential practical importance, and that if the necessary information were available it might be applied to the more economical production of milk, both by increasing milk yield and by reducing mortality from disease.With regard to the information we do possess, much of it is not immediately applicable in practice because the data have been accumulated with diets and under conditions which have no parallel in practice. The following conclusions sum up in a general way the practical bearing of our present knowledge.

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“…per day. Shohl (7) found a base-forming diet essential to calcium storage in the young. Baumann and Howard (8) and Chaney and Blunt (9) found that calcium assimilation was decidedly benefited by orange juice.…”

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confidence: 99%