Mineral element determination and phenolic compounds profiling of oleoresin extracts using an accurate mass LC-MS-QTOF and ICP-MS

Olalere, Olusegun Abayomi; Abdurahman, Nour Hamid; Yunus, Rosli Bin Mohd; Alara, Oluwaseun Ruth

doi:10.1016/j.jksus.2018.05.018

Cited by 18 publications

(9 citation statements)

References 17 publications

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“…LC-MS has the ability to incorporate several mass analyzers with an unequalled capacity for component identification and mass quantification with suitable ionization and acquisition parameters. The parameters used in this analysis are in accordance with Olalere et al [15]. Figure 1 showed a steady rise in the total phenolics between (from 1 to 2 min) up to 5 min of threshold microwave duration.…”

Section: Lcms Qtof Phenolics Profilingsupporting

confidence: 76%

Multi-step reflux extraction of bio-pharmaceutical phenolic bioactives from balsam apple (Momordica balsamina L.)

Olalere

Gan

2020

Journal of Taibah University for Science

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In this study, the impacts of parameter combinations on the response (total phenolic yield) were evaluated using the single experiments and two-level factorial design. The investigated parameters with their value range include; the microwave extraction time (1-5 min), power level (400-600 W), temperature (60-80°C), the solvent-feed ratio, SFR (8-12 mL/g) and solvent concentration (50-80%). The result of this investigation succinctly presented the solvent concentration as the highest contributing parameters, far above the Bonferroni limit (8.37517) and t-value limit (3.18245). However, the temperature, SFR and microwave duration provided insignificant contribution to the response settings. The result of the spectrometry chromatographic analysis identified 22 phenolics compounds from the extracts which invariably revealed their potential biological functions. The study therefore adequately elucidated the contributing factor in the microwave recovery of total phenolic constituents from the M. balsamina leaves with potential use as scale-up parameters in drug applications.

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Section: Lcms Qtof Phenolics Profilingsupporting

confidence: 76%

Multi-step reflux extraction of bio-pharmaceutical phenolic bioactives from balsam apple (Momordica balsamina L.)

Olalere

Gan

2020

Journal of Taibah University for Science

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“…OH = (301 − h) × 5/300 + (301 − 1) × 7/300 + (301 − c) × 9/300 (5) where h is the time to beginning of hemorrhage, l time to lysis, and c time to coagulation. The following classification was used: OII ≤ 0.9, slightly irritating; 0.9 < OII ≤ 4.9, moderately irritating; 4.9 < OII ≤ 8.9, irritating; and 8.9 < OII ≤ 21, severely irritating.…”

Section: Cytotoxicitymentioning

confidence: 99%

“…Recently, several studies focused on plant phenolic compounds owing to their significant potential for promoting human health and lowering the hazards of various diseases [ 1 , 2 , 3 ]. Mineral elements and phenolic compounds are considered to play important roles in the antioxidant properties of plants [ 4 , 5 ]. Minerals such as Zn, Cu, and Re reportedly play important roles in the antioxidant potential of plants by serving as cofactors for antioxidant enzymes and cytochromes [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of Lycium chinense Miller

Thiruvengadam

Ghimire

Kim

et al. 2020

Plants

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This study aimed at investigating the Lycium chinense Miller leaf extract mineral and phenolic compound profiles as well as antioxidant and antimicrobial potential. We determined the leaf extract mineral composition, identified its major mineral components, and quantified secondary metabolites. We also measured the leaf extract antioxidant potential and found that it varies in a concentration-dependent manner. We observed a significant and higher positive correlation between DPPH and ABTS assays compared with the total phenolic and flavonoid content. Furthermore, our assay results positively correlated with several observed acids, indicating their strong association with the L. chinense antioxidant potential. Our cytotoxic assay revealed weak toxicity at higher tested concentrations. Our MIC assay showed that the 80% methanol extract effectively inhibited the growth of Escherichia coli Castellani and Chalmers (ATCC35150). The 625-ppm leaf extract completely suppressed the growth of Staphylococcus aureus Rosenbach (ATCC13150), Bacillus cereus (ATCC 14579), and Helicobacter pylori (ATCC43504). These results allow us to understand the indigenous medicinal value of L. chinense. Our study suggests that the L. chinense leaf extract phenolic compounds possess a good antioxidant activity against free radicals and are effective antimicrobial agents. Finally, the presence and high level of diverse minerals suggest the potential of L. chinense for nutraceutical and functional food applications.

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“…The solvent A is made of 0.1% formic acid (Sigma Aldrich®, Germany) plus water (Milli-Q grade, v/v). However, solvent B was 0.1% formic acid in acetonitrile at a seal wash time and highest pressure limit of 5 min and 1800 psi, respectively [2] . The two solvents were then passed through the vacuum degasser.…”

Section: Material Methods and Sample Preparationmentioning

confidence: 99%

Data article on elemental and metabolomic-based alkaloidal composition in black pepper oleoresin using a positive ESI-mode LC-QToF and ICP-mass spectroscopy

et al. 2018

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This paper contains data from the elemental and phytochemical profiling of black pepper oleoresin extracts using the LC–MS QToF and ICP-MS analysis. In recent years studies have shown the medicinal properties of extracts from these two cultivars of Piper nigrum. The medicinal properties are attributed to the presence of many secondary metabolites and mineral element in them. The phytochemical profiling was conducted using a Liquid Chromatography equipped with an electrospray time-of-flight mass spectrometer detectors. The mass spectrometer was equipped with an electrospray ionization sources operated in positive ion mode. The alkaloid compounds in the optimized black pepper extract were tentatively characterized in accordance with their ions׳ mass fragmentation.

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Mineral element determination and phenolic compounds profiling of oleoresin extracts using an accurate mass LC-MS-QTOF and ICP-MS

Cited by 18 publications

References 17 publications

Multi-step reflux extraction of bio-pharmaceutical phenolic bioactives from balsam apple (Momordica balsamina L.)

Multi-step reflux extraction of bio-pharmaceutical phenolic bioactives from balsam apple (Momordica balsamina L.)

Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of Lycium chinense Miller

Data article on elemental and metabolomic-based alkaloidal composition in black pepper oleoresin using a positive ESI-mode LC-QToF and ICP-mass spectroscopy

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