Assessment of Mineral and Phenolic Profiles and Their Association with the Antioxidant, Cytotoxic Effect, and Antimicrobial Potential of Lycium chinense Miller

Abstract

This study aimed at investigating the Lycium chinense Miller leaf extract mineral and phenolic compound profiles as well as antioxidant and antimicrobial potential. We determined the leaf extract mineral composition, identified its major mineral components, and quantified secondary metabolites. We also measured the leaf extract antioxidant potential and found that it varies in a concentration-dependent manner. We observed a significant and higher positive correlation between DPPH and ABTS assays compared with the total phenolic and flavonoid content. Furthermore, our assay results positively correlated with several observed acids, indicating their strong association with the L. chinense antioxidant potential. Our cytotoxic assay revealed weak toxicity at higher tested concentrations. Our MIC assay showed that the 80% methanol extract effectively inhibited the growth of Escherichia coli Castellani and Chalmers (ATCC35150). The 625-ppm leaf extract completely suppressed the growth of Staphylococcus aureus Rosenbach (ATCC13150), Bacillus cereus (ATCC 14579), and Helicobacter pylori (ATCC43504). These results allow us to understand the indigenous medicinal value of L. chinense. Our study suggests that the L. chinense leaf extract phenolic compounds possess a good antioxidant activity against free radicals and are effective antimicrobial agents. Finally, the presence and high level of diverse minerals suggest the potential of L. chinense for nutraceutical and functional food applications.

Influence of Harvesting Time on Phenolic and Mineral Profiles and Their Association with the Antioxidant and Cytotoxic Effects of Atractylodes japonica Koidz

“…For example, higher rutin, chlorogenic acid, and luteolin concentrations significantly reduced the growth of NIH/3T3 cells. Similarly, there was a strong positive correlation between cytotoxicity and the concentration of protocatechuic acid, chlorogenic acid, p-coumaric acid, salicylic acid, quercetin, luteolin, and quercetin derivatives [80][81][82][83]. Here, we observed a strong positive correlation between cytotoxicity and p-coumaric acid, salicylic acid, chlorogenic acid, salicylic acid, and rutin contents, suggesting that the higher concentration of these compounds is associated with the cytotoxicity effect of A. japonica.…”

Multielement Characterization and Antioxidant Activity of Italian Extra-Virgin Olive Oils

“…Phenolic compounds have antioxidant capacities in EVOO since they can eliminate peroxyl and alkoxy radicals and chelate transition metal ions present in traces ( Visioli et al, 1998 ). Several elements are known for their antioxidant properties ( Perna et al, 2012 ; Thiruvengadam et al, 2020 ). Indeed, in the present study ( Supplementary Table S8 ), significant correlations were observed between the antioxidant activity and elements.…”

New Phenolic Compounds in Posidonia oceanica Seagrass: A Comprehensive Array Using High Resolution Mass Spectrometry

“…Due to their specific and rapid response when changes in the environment occur, phenolic compounds have been proved to be suitable biomarkers or early warnings [ 9 , 10 , 11 , 12 ]. These compounds are specialized metabolites that benefit the bearing organism through several biological properties (e.g., antioxidant capacity) [ 13 ]. Interest in this field has been growing, given the potential medical contributions of such phenolic compounds to human health and personal care: immunostimulant and antitumoral drugs or products for skin aging [ 14 , 15 ].…”