Mineral Content and Antisickling Activity of  Annona senegalensis, Alchornea cordifolia and  Vigna unguiculata Used in the Management of  Sickle Cell Disease in the Kwilu Province  (Congo, DR)

Kitadi, Jules M.; Inkoto, Clément L.; Lengbiye, Emmanuel M.; Tshibangu, Damien S. T.; Tshilanda, Dorotheé D.; Ngbolua, Koto-te-Nyiwa; Taba, Kalulu M.; Mbala, Blaise Mavinga; Schmitz, Brigitte; Mpiana, Pius T.

doi:10.9734/ibrr/2020/v11i330131

Cited by 3 publications

(1 citation statement)

References 14 publications

(20 reference statements)

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“…It was concluded that the three plants possess an interesting capacity to prevent the sickling and hemolysis of red blood cells. 69 Mpiana et al, 70 evaluated the antisickling activity of aqueous and diethyl ether extracts of anthocyanins from two Congolese medicinal plants: A. cordifolia and C. retusa using Emmel's test. Additionally, thin layer chromatography (TLC) helped to prepare with methanol two different fractions (Rf: 0.76; 0.68) for A. cordifolia.…”

Section: Antisickling Activitymentioning

confidence: 99%

A mini-review on ethnomedical uses, chemical constituents, pharmacological activities and toxicological study of Alchornea cordifolia (Schum & Thonn) Muell. Arg

Ngbolua¹,

Blaise²,

Damien³

et al. 2022

PPIJ

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Medicinal plants have played and continue to play a very important role as medicines or sources of therapeutic molecules throughout the world. Numerous people in developing countries use their therapeutic virtues to treat their health. Among those plants, Alchornea cordiflia is in a prominent position due to its numerous beneficial effects on both human and animal health. This plant is known in several African pharmacopoeias as an effective remedy against many diseases, including toothaches, inflammation, malaria, and worms. Advanced research on this plant has revealed a number of bioactive compounds such as cardiac glycosides, anthraquinones, polyphenols, triterpenes, and steroids, which give this plant its extraordinary pharmacological activities. Thus, many biological activities such as anti-inflammation, anticancer, antioxidant, antidiarrhoeal, antimicrobial, hepatoprotective, antiplasmodial are reported in this plant. More recently, a study has reported that this plant is included in the food chain of the Okapia johnstoni in the wild. Because of its composition rich in alkaloids, flavonoids, tannins, triterpenoids, an assessment of the anthelmintic activity of this plant on the intestinal worms of the Okapia johnstoni would be very interesting for the ex situ conservation of this emblematic animal.

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Section: Antisickling Activitymentioning

confidence: 99%

A mini-review on ethnomedical uses, chemical constituents, pharmacological activities and toxicological study of Alchornea cordifolia (Schum & Thonn) Muell. Arg

Ngbolua¹,

Blaise²,

Damien³

et al. 2022

PPIJ

Self Cite

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Studies on the chemical composition of plants used in traditional medicine in Congo

et al. 2022

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The knowledge of the chemical composition of herbs used medicinally in Africa is relatively low, and at the same time, the growing interest in alternative medicine prompts scientists to search for justification for the use of various plants. Due to these, the aim of the study was to analyze ten botanical species of medicinal plants originating from Congo to determine the contents of non-metals (P, Se), metallic elements (Cu, Zn, Fe, Mn, Ca, Mg, Na, K, Cd, Pb, Cr, Co, Al), phenolic compounds, and L(+) ascorbic acid and antioxidant activities. To prepare plant samples for quantitative analysis by flame atomic absorption spectrometry (FAAS) and inductively coupled plasma-optical emission spectroscopy, the microwave digestion was applied. The contents of phenolic acids, flavonoids, polyphenolic compounds, and vitamin C were assayed in extracts of medicinal plants spectrophotometrically, while the antioxidant activity was determined by ferric reducing antioxidant power (FRAP), 2,2-Diphenyl-1-picryl-hydrazyl-hydrate (DPPH), and 2,2 -Azino-bis-3-ethylbanzothiazoline-6-sulfonic acid (ABTS) techniques. The studies showed that the medicinal plants from Congo differed to a high degree. Principal component analysis demonstrated that the concentrations of Cu, Fe, Mn, and also phenolic compounds and antioxidant activity had the highest impact on sample’s differentiation. The relationship between the type of plant material (bark, root, or leaf) and its chemical composition was noticed, too.

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Traditional Drugs Originating from Selected Medicinal Plants: An Intervention for Anaemia

Gupta¹,

Chalotra²,

Dhanawat

et al. 2023

CTM

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Background: Anaemia is the most common disease that affects mostly females and children and is most prevalent in developing countries. Among various causes sickle cell anaemia is one of them, which is a cause of concern. Sickle Cell Disease (SCD) causes problems like blockage of blood flow, causing pain, and fatigue and also leads to death. Objective: With the advancement in science, diseases that were once considered unable to cure can be stopped or prevented and, in some cases, also be cured. As current therapies for the treatment of sickle cell anaemia are limited, like blood transfusions, bone marrow transfusions, etc., a non-surgical method where plant extracts or compounds were found effective in stopping, preventing, and in some cases reversal of SCD. In this review, we tried to gather information about those plants and compounds. Method: Numerous surveys in the literature were performed to determine the plants which have shown their potential against SCD. Relevant peer-reviewed publications were searched through various databases such as ScienceDirect, PubMed, Google Scholar, Research Gate, etc. Results: A total of more than 50 medicinal plants such as Acacia catechu, Alchornea cordifolia, Anchomanes difformis, Khayase negalensis, Terminalia catappa, etc., have been identified based on their potential against SCD, and 15 compounds such as Butylurea, Glyceraldehyde, Potassium cyanate, urea, etc., have also been identified which could work against SCD. These plants acting on sickle cell anemia on various pathways are also discussed. Conclusion: In this review, an approach was made to study those plants which have an effect against SCD, with proper mechanisms and compounds that show potency against this disease. So that better treatment options could be available for future generations.

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Mineral Content and Antisickling Activity of Annona senegalensis, Alchornea cordifolia and Vigna unguiculata Used in the Management of Sickle Cell Disease in the Kwilu Province (Congo, DR)

Cited by 3 publications

References 14 publications

A mini-review on ethnomedical uses, chemical constituents, pharmacological activities and toxicological study of Alchornea cordifolia (Schum & Thonn) Muell. Arg

A mini-review on ethnomedical uses, chemical constituents, pharmacological activities and toxicological study of Alchornea cordifolia (Schum & Thonn) Muell. Arg

Studies on the chemical composition of plants used in traditional medicine in Congo

Traditional Drugs Originating from Selected Medicinal Plants: An Intervention for Anaemia

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