Mindfulness Meditation Is Related to Long-Lasting Changes in Hippocampal Functional Topology during Resting State: A Magnetoencephalography Study

Lardone, Anna; Liparoti, Marianna; Sorrentino, Pierpaolo; Rucco, Rosaria; Jacini, Francesca; Polverino, Arianna; Minino, Roberta; Pesoli, Matteo; Baselice, Fabio; Sorriso, Antonietta; Ferraioli, Giampaolo; Sorrentino, Giuseppe; Mandolesi, Laura

doi:10.1155/2018/5340717

Cited by 55 publications

(45 citation statements)

References 75 publications

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“…Magnetoencephalographic data were acquired in a 163-magnetometers MEG system 55 , with 9 reference sensors, located in a magnetically shielded room (AtB Biomag UG, Ulm, Germany). The position of four position coils and four reference points (nasion, right and left pre-auricular and apex) were digitized before acquisition, using Fastrak (Polhemus).…”

Section: Methodsmentioning

confidence: 99%

Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease

Sorrentino

Rucco

Baselice

et al. 2021

Sci Rep

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Rapid reconfigurations of brain activity support efficient neuronal communication and flexible behaviour. Suboptimal brain dynamics is associated to impaired adaptability, possibly leading to functional deficiencies. We hypothesize that impaired flexibility in brain activity can lead to motor and cognitive symptoms of Parkinson’s disease (PD). To test this hypothesis, we studied the ‘functional repertoire’—the number of distinct configurations of neural activity—using source-reconstructed magnetoencephalography in PD patients and controls. We found stereotyped brain dynamics and reduced flexibility in PD. The intensity of this reduction was proportional to symptoms severity, which can be explained by beta-band hyper-synchronization. Moreover, the basal ganglia were prominently involved in the abnormal patterns of brain activity. Our findings support the hypotheses that: symptoms in PD relate to impaired brain flexibility, this impairment preferentially involves the basal ganglia, and beta-band hypersynchronization is associated with reduced brain flexibility. These findings highlight the importance of extensive functional repertoires for correct behaviour.

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Section: Methodsmentioning

confidence: 99%

Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease

Sorrentino

Rucco

Baselice

et al. 2021

Sci Rep

Self Cite

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“…The MEG data were filtered in the band 0.5-48 Hz using a 4th-order Butterworth IIR band-pass filter, implemented offline using Matlab scripts within the Fieldtrip toolbox (44). As described previously (45), Principal Component Analysis was applied to reference SQUID signals to remove the environment noise. Subsequently, noisy channels and bad segments of acquisition were identified and removed through visual inspection by an experienced rater.…”

Section: Meg Acquisition and Preprocessingmentioning

confidence: 99%

Clinical connectome fingerprints of cognitive decline

Sorrentino

Rucco

Lardone

et al. 2020

Preprint

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Brain connectome fingerprinting is rapidly rising as a novel influential field in brain network analysis. Yet, it is still unclear whether connectivity fingerprints could be effectively used for mapping and predicting disease progression from human brain data. We hypothesize that dysregulation of brain activity in disease would reflect in worse subject identification. Hence, we propose a novel framework, Clinical Connectome Fingerprinting, to detect individual connectome features from clinical populations. We show that “clinical fingerprints” can map individual variations between elderly healthy subjects and patients undergoing cognitive decline in functional connectomes extracted from magnetoencephalography data. We find that identifiability is reduced in patients as compared to controls, and show that these connectivity features are predictive of the individual Mini-Mental State Examination (MMSE) score in patients. We hope that the proposed methodology can help in bridging the gap between connectivity features and biomarkers of brain dysfunction in large-scale brain networks.

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“…To this end, we applied a dynamic analysis framework to delineate the spatiotemporal characteristics of dynamic FC, which estimates the temporal efficiency of information flow within the brain. Given that brain FC is impaired in MCI and that mindfulness is associated with positive structural and functional connectivity changes in healthy volunteers, we hypothesize that mindfulness practice would improve dynamic FC in subjects with MCI.…”

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confidence: 99%

Mindfulness practice alters brain connectivity in community‐living elders with mild cognitive impairment

Fam

Sun

et al. 2020

Psychiatry Clin Neurosci

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Aim There is increasing evidence that mild cognitive impairment (MCI) is associated with widespread brain dysconnectivity. Mindfulness practice, which involves focused attention to experience the present moment in a purposeful way, has been shown to confer positive psychological and functional brain changes in healthy practitioners. It is unclear whether mindfulness practice could improve functional brain connectivity in older adults with cognitive impairment. Methods Forty‐seven participants with MCI were randomized into two groups: a mindfulness practice group and a control group. Functional magnetic resonance imaging of the brain and neurocognitive tests were performed before and after the 3‐month intervention. A temporal efficiency analysis approach was used to examine the spatiotemporal networks of the brain. Results Participants in the mindfulness group had significantly better temporal global efficiency than controls after 3‐months of intervention. Localized changes of temporal nodal properties were present in the right cingulate gyrus, insula, and left superior temporal gyrus. Together, these results suggest greater information transmission efficiency at both the global and local spatiotemporal level. In terms of cognitive function, verbal recognition memory improved in the mindfulness group compared to the controls. Conclusion Elders who practiced mindfulness had better brain network efficiency and neurocognitive function relative to controls in this study, suggesting that mindfulness may be of benefit to aging adults with early cognitive degeneration.

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Mindfulness Meditation Is Related to Long-Lasting Changes in Hippocampal Functional Topology during Resting State: A Magnetoencephalography Study

Cited by 55 publications

References 75 publications

Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease

Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease

Clinical connectome fingerprints of cognitive decline

Mindfulness practice alters brain connectivity in community‐living elders with mild cognitive impairment

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