2021
DOI: 10.1038/s41598-021-83425-4
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Flexible brain dynamics underpins complex behaviours as observed in Parkinson’s disease

Abstract: Rapid reconfigurations of brain activity support efficient neuronal communication and flexible behaviour. Suboptimal brain dynamics is associated to impaired adaptability, possibly leading to functional deficiencies. We hypothesize that impaired flexibility in brain activity can lead to motor and cognitive symptoms of Parkinson’s disease (PD). To test this hypothesis, we studied the ‘functional repertoire’—the number of distinct configurations of neural activity—using source-reconstructed magnetoencephalograph… Show more

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Cited by 59 publications
(79 citation statements)
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References 65 publications
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“…Furthermore, in agreement with previous studies (Kim et al, 2017 ; Schumacher et al, 2019 ; Sorrentino et al, 2021 ), we also found that the reduced brain dynamic changes were significantly associated with clinical symptoms, indicating that longer mean duration correlated with a more severe movement disorder. In addition, we found the occurrences per second of microstates were negatively correlated with neural function, in agreement with former results.…”
Section: Discussionsupporting
confidence: 93%
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“…Furthermore, in agreement with previous studies (Kim et al, 2017 ; Schumacher et al, 2019 ; Sorrentino et al, 2021 ), we also found that the reduced brain dynamic changes were significantly associated with clinical symptoms, indicating that longer mean duration correlated with a more severe movement disorder. In addition, we found the occurrences per second of microstates were negatively correlated with neural function, in agreement with former results.…”
Section: Discussionsupporting
confidence: 93%
“…Schumacher et al (2019) examined the brain dynamic changes of Lewy body dementia (including PD dementia) using the EEG microstate analysis and found obvious decreases compared with controls. Coincidentally, Kim et al (2017) (Sorrentino et al, 2021). In our results, the longer mean duration of a microstate is parallel to the longer mean dwell time and fewer occurrences in each microstate, which means reduced flexibility of the brain.…”
Section: Clinical Correlationssupporting
confidence: 53%
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“…MEG pre-processing and source reconstruction were performed as in (22). The MEG system was equipped with magnetometers, and was developed by the National Research Council of Italy at the Institute of Applied Sciences and Intelligent Systems (ISASI).…”
Section: Meg Pre-processingmentioning
confidence: 99%
“…2.5 and 3.5) were tested. An avalanche was defined as starting when any region is above threshold, and finishing when no region is active, as in (22). Avalanches shorter than 10 time bins (~30 msec) were excluded.…”
Section: Transition Matricesmentioning
confidence: 99%